- Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock
[作者:Sekine, H; Mimura, J; Oshima, M; Okawa, H; Kanno, J; Igarashi, K; Gonzalez, FJ; Ikuta, T; Kawajiri, K; Fujii-Kuriyama, Y,期刊:Molecular and Cellular Biology, 页码:6391-6400 , 文章类型: Article,,卷期:2009年29-24]
- Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Recent studies have re...
- Mammalian Casein Kinase 1 alpha and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling
[作者:Liu, JH; Carvalho, LP; Bhattacharya, S; Carbone, CJ; Kumar, KGS; Leu, NA; Yau, PM; Donald, RGK; Weiss, MJ; Baker, DP; McLaughlin, KJ; Scott, P; Fuchs, SY,期刊:Molecular and Cellular Biology, 页码:6401-6412 , 文章类型: Article,,卷期:2009年29-24]
- Phosphorylation of the degron of the IFNAR1 chain of the type I interferon (IFN) receptor triggers ubiquitination and degradation of this receptor and, therefore, plays a crucial role in negative regulation of IFN-alpha/...
- XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair
[作者:Bhagwat, N; Olsen, AL; Wang, AT; Hanada, K; Stuckert, P; Kanaar, R; D'Andrea, A; Niedernhofer, LJ; McHugh, PJ,期刊:Molecular and Cellular Biology, 页码:6427-6437 , 文章类型: Article,,卷期:2009年29-24]
- Interstrand cross-links (ICLs) prevent DNA strand separation and, therefore, transcription and replication, making them extremely cytotoxic. The precise mechanism by which ICLs are removed from mammalian genomes largely ...
- Alternative Splicing Modulates Autoinhibition and SH3 Accessibility in the Src Kinase Fyn
[作者:Brignatz, C; Paronetto, MP; Opi, S; Cappellari, M; Audebert, S; Feuillet, V; Bismuth, G; Roche, S; Arold, ST; Sette, C; Collette, Y,期刊:Molecular and Cellular Biology, 页码:6438-6448 , 文章类型: Article,,卷期:2009年29-24]
- Src family kinases are central regulators of a large number of signaling pathways. To adapt to the idiosyncrasies of different cell types, these kinases may need a fine-tuning of their intrinsic molecular control mechani...
- Set2-Dependent K36 Methylation Is Regulated by Novel Intratail Interactions within H3
[作者:Psathas, JN; Zheng, S; Tan, S; Reese, JC,期刊:Molecular and Cellular Biology, 页码:6413-6426 , 文章类型: Article,,卷期:2009年29-24]
- Posttranslational modifications to histones have been studied extensively, but the requirement for the residues within the tails for different stages of transcription is less clear. Using RNR3 as a model, we found that t...
- Transforming Potential of Src Family Kinases Is Limited by the Cholesterol-Enriched Membrane Microdomain
[作者:Oneyama, C; Iino, T; Saito, K; Suzuki, K; Ogawa, A; Okada, M,期刊:Molecular and Cellular Biology, 页码:6462-6472 , 文章类型: Article,,卷期:2009年29-24]
- The upregulation of Src family kinases (SFKs) has been implicated in cancer progression, but the molecular mechanisms regulating their transforming potentials remain unclear. Here we show that the transforming ability of...
- NuA4 Lysine Acetyltransferase Esa1 Is Targeted to Coding Regions and Stimulates Transcription Elongation with Gcn5
[作者:Ginsburg, DS; Govind, CK; Hinnebusch, AG,期刊:Molecular and Cellular Biology, 页码:6473-6487 , 文章类型: Article,,卷期:2009年29-24]
- NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces cerevisiae, is recruited to promoters and stimulates transcription initiation. NuA4 subunits contain domains that bind methylated histones, sugge...
- Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals
[作者:Chaveroux, C; Jousse, C; Cherasse, Y; Maurin, AC; Parry, L; Carraro, V; Derijard, B; Bruhat, A; Fafournoux, P,期刊:Molecular and Cellular Biology, 页码:6515-6526 , 文章类型: Article,,卷期:2009年29-24]
- It has been well established that amino acid availability can control gene expression. Previous studies have shown that amino acid depletion induces transcription of the ATF3 (activation transcription factor 3) gene thro...
- Two Fundamentally Distinct PCNA Interaction Peptides Contribute to Chromatin Assembly Factor 1 Function
[作者:Ben-Shahar, TR; Castillo, AG; Osborne, MJ; Borden, KLB; Kornblatt, J; Verreault, A,期刊:Molecular and Cellular Biology, 页码:6353-6365 , 文章类型: Article,,卷期:2009年29-24]
- Chromatin assembly factor 1 (CAF-1) deposits histones H3 and H4 rapidly behind replication forks through an interaction with the proliferating cell nuclear antigen (PCNA), a DNA polymerase processivity factor that also b...
- MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21(Waf1/Cip1) Stability
[作者:Densham, RM; O'Neill, E; Munro, J; Koig, I; Anderson, K; Kolch, W; Olson, MF,期刊:Molecular and Cellular Biology, 页码:6380-6390 , 文章类型: Article,,卷期:2009年29-24]
- As well as providing a structural framework, the actin cytoskeleton plays integral roles in cell death, survival, and proliferation. The disruption of the actin cytoskeleton results in the activation of the c-Jun N-termi...
- Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic beta-Cell Development and Insulin Gene Expression
[作者:Kang, HS; Kim, YS; ZeRuth, G; Beak, JY; Gerrish, K; Kilic, G; Sosa-Pineda, B; Jensen, J; Foley, J; Jetten, AM,期刊:Molecular and Cellular Biology, 页码:6366-6379 , 文章类型: Article,,卷期:2009年29-24]
- In this study, we report that the Kruppel-like zinc finger transcription factor Gli-similar 3 (Glis3) is induced during the secondary transition of pancreatic development, a stage of cell lineage specification and extens...
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