- Hnf1 alpha (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver
[作者:Servitja, JM; Pignatelli, M; Maestro, MA; Cardalda, C; Boj, SF; Lozano, J; Blanco, E; Lafuente, A; McCarthy, MI; Sumoy, L; Guigo, R; Ferrer, J,期刊:Molecular and Cellular Biology, 页码:2945-2959 , 文章类型: Article,,卷期:2009年29-11]
- Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MODY3). Hnf1 alpha is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more...
- Properties of Nat4, an N-alpha-Acetyltransferase of Saccharomyces cerevisiae That Modifies N Termini of Histones H2A and H4
[作者:Polevoda, B; Hoskins, J; Sherman, F,期刊:Molecular and Cellular Biology, 页码:2913-2924 , 文章类型: Article,,卷期:2009年29-11]
- Nat4, also designated NatD, was previously shown to acetylate the N termini of histones H2A and H4, which have SGGKG and SGRGK N termini (O. K. Song, X. Wang, J. H. Waterborg, and R. Sternglanz, J. Biol. Chem. 278: 38109...
- Differential Cofactor Requirements for Histone Eviction from Two Nucleosomes at the Yeast PHO84 Promoter Are Determined by Intrinsic Nucleosome Stability
[作者:Wippo, CJ; Krstulovic, BS; Ertel, F; Musladin, S; Blaschke, D; Sturzl, S; Yuan, GC; Horz, W; Korber, P; Barbaric, S,期刊:Molecular and Cellular Biology, 页码:2960-2981 , 文章类型: Article,,卷期:2009年29-11]
- We showed previously that the strong PHO5 promoter is less dependent on chromatin cofactors than the weaker coregulated PHO8 promoter. In this study we asked if chromatin remodeling at the even stronger PHO84 promoter wa...
- Integrating Receptor Signal Inputs That Influence Small Rho GTPase Activation Dynamics at the Immunological Synapse
[作者:Makrogianneli, K; Carlin, LM; Keppler, MD; Matthews, DR; Ofo, E; Coolen, A; Ameer-Beg, SM; Barber, PR; Vojnovic, B; Ng, T,期刊:Molecular and Cellular Biology, 页码:2997-3006 , 文章类型: Article,,卷期:2009年29-11]
- The Rho GTPase Cdc42 regulates cytoskeletal changes at the immunological synapse (IS) that are critical to T-cell activation. By imaging fluorescent activity biosensors (Raichu) using fluorescence lifetime imaging micros...
- A Novel Small-Subunit Processome Assembly Intermediate That Contains the U3 snoRNP, Nucleolin, RRP5, and DBP4
[作者:Turner, AJ; Knox, AA; Prieto, JL; McStay, B; Watkins, NJ,期刊:Molecular and Cellular Biology, 页码:3007-3017 , 文章类型: Article,,卷期:2009年29-11]
- Eukaryotic 18S rRNA processing is mediated by the small subunit (SSU) processome, a machine comprised of the U3 small nucleolar RNP (U3 snoRNP), tUTP, bUTP, MPP10, and BMS1/RCL1 subcomplexes. We report that the human SSU...
- Pak4, a Novel Gab1 Binding Partner, Modulates Cell Migration and Invasion by the Met Receptor
[作者:Paliouras, GN; Naujokas, MA; Park, M,期刊:Molecular and Cellular Biology, 页码:3018-3032 , 文章类型: Article,,卷期:2009年29-11]
- Hepatocyte growth factor (HGF), the ligand for the Met receptor tyrosine kinase, induces epithelial cell dispersal, invasion, and morphogenesis, events that require remodeling of the actin cytoskeleton. The scaffold prot...
- The Protocadherin Gene Celsr3 Is Required for Interneuron Migration in the Mouse Forebrain
[作者:Ying, GX; Wu, S; Hou, RQ; Huang, W; Capecchi, MR; Wu, Q,期刊:Molecular and Cellular Biology, 页码:3045-3061 , 文章类型: Article,,卷期:2009年29-11]
- Interneurons are extremely diverse in the mammalian brain and provide an essential balance for functional neural circuitry. The vast majority of murine cortical interneurons are generated in the subpallium and migrate ta...
- Structural and Functional Basis of a Role for CRKL in a Fibroblast Growth Factor 8-Induced Feed-Forward Loop
[作者:Seo, JH; Suenaga, A; Hatakeyama, M; Taiji, M; Imamoto, A,期刊:Molecular and Cellular Biology, 页码:3076-3087 , 文章类型: Article,,卷期:2009年29-11]
- The adapter protein CRKL is required for the normal development of multiple tissues that rely on fibroblast growth factor 8 (FGF8). The precise role of CRKL in receptor signaling has been unclear, however. To address thi...
- p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon
[作者:Mukhopadhyay, UK; Eves, R; Jia, L; Mooney, P; Mak, AS,期刊:Molecular and Cellular Biology, 页码:3088-3098 , 文章类型: Article,,卷期:2009年29-11]
- The tumor-suppressive role of p53 at the level of tumor initiation is well documented. It has also been shown previously that p53 acts against tumor progression/metastasis. However, its role in modulating cell migration ...
- Execution of Superoxide-Induced Cell Death by the Proapoptotic Bcl-2-Related Proteins Bid and Bak
[作者:Madesh, M; Zong, WX; Hawkins, BJ; Ramasamy, S; Venkatachalam, T; Mukhopadhyay, P; Doonan, PJ; Irrinki, KM; Rajesh, M; Pacher, P; Thompson, CB,期刊:Molecular and Cellular Biology, 页码:3099-3112 , 文章类型: Article,,卷期:2009年29-11]
- Ethanol intoxication stimulates the production of proinflammatory cytokines, increases the formation of reactive oxygen species, and induces mitochondrial impairment. However, information is limited as to the exact seque...
- Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells
[作者:Jansen, JG; Tsaalbi-Shtylik, A; Hendriks, G; Gali, H; Hendel, A; Johansson, F; Erixon, K; Livneh, Z; Mullenders, LHF; Haracska, L; de Wind, N,期刊:Molecular and Cellular Biology, 页码:3113-3123 , 文章类型: Article,,卷期:2009年29-11]
- The Y family DNA polymerase Rev1 has been proposed to play a regulatory role in the replication of damaged templates. To elucidate the mechanism by which Rev1 promotes DNA damage bypass, we have analyzed the progression ...
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