- Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis
[作者:Xie, ZL; Dong, YZ; Zhang, JH; Scholz, R; Neumann, D; Zou, MH,期刊:Molecular and Cellular Biology, 页码:3582-3596 , 文章类型: Article,,卷期:2009年29-13]
- LKB1, a master kinase that controls at least 13 downstream protein kinases including the AMP-activated protein kinase (AMPK), resides mainly in the nucleus. A key step in LKB1 activation is its export from the nucleus to...
- DNA Damage-Induced Phosphorylation of TRF2 Is Required for the Fast Pathway of DNA Double-Strand Break Repair
[作者:Huda, N; Tanaka, H; Mendonca, MS; Gilley, D,期刊:Molecular and Cellular Biology, 页码:3597-3604 , 文章类型: Article,,卷期:2009年29-13]
- Protein kinases of the phosphatidylinositol 3-kinase-like kinase family, originally known to act in maintaining genomic integrity via DNA repair pathways, have been shown to also function in telomere maintenance. Here we...
- Novel Types of Ca2+ Release Channels Participate in the Secretory Cycle of Paramecium Cells
[作者:Ladenburger, EM; Sehring, IM; Korn, I; Plattner, H,期刊:Molecular and Cellular Biology, 页码:3605-3622 , 文章类型: Review,,卷期:2009年29-13]
- A database search of the Paramecium genome reveals 34 genes related to Ca2+-release channels of the inositol-1,4,5-trisphosphate (IP3) or ryanodine receptor type (IP3R, RyR). Phylogenetic analyses show that these Ca2+ re...
- Organization of F-Actin via Concerted Regulation of Kette by PTP61F and dAbl
[作者:Ku, HY; Wu, CL; Rabinow, L; Chen, GC; Meng, TC,期刊:Molecular and Cellular Biology, 页码:3623-3632 , 文章类型: Article,,卷期:2009年29-13]
- We identify Kette, a key regulator of actin polymerization, as a substrate for Drosophila protein tyrosine phosphatase PTP61F, as well as for dAbl tyrosine kinase. We further show that dAbl is a direct substrate for PTP6...
- ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription
[作者:Qin, Z; Ren, FL; Xu, XL; Ren, YM; Li, HG; Wang, YY; Zhai, YG; Chang, ZJ,期刊:Molecular and Cellular Biology, 页码:3633-3643 , 文章类型: Article,,卷期:2009年29-13]
- Neuronal differentiation is tightly regulated by a variety of factors. In a search for neuron-specific genes, we identified a highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 is most abundant i...
- Dynamin Reduces Pyk2 Y402 Phosphorylation and Src Binding in Osteoclasts
[作者:Bruzzaniti, A; Neff, L; Sandoval, A; Du, LP; Horne, WC; Baron, R,期刊:Molecular and Cellular Biology, 页码:3644-3656 , 文章类型: Article,,卷期:2009年29-13]
- Signaling via the Pyk2-Src-Cbl complex downstream of integrins contributes to the assembly, organization, and dynamics of podosomes, which are the transient adhesion complexes of highly motile cells such as osteoclasts a...
- Caspase-10-Mediated Heat Shock Protein 90 beta Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis
[作者:Chen, HH; Xia, Y; Fang, DX; Hawke, D; Lu, ZM,期刊:Molecular and Cellular Biology, 页码:3657-3664 , 文章类型: Article,,卷期:2009年29-13]
Heat shock protein 90 beta (Hsp90 beta) is involved in many cellular functions. However, the posttranslational modification of Hsp90 beta, especially in response to apoptotic stimulation, is not well understood. In th...
- Identification of a Novel System for Boron Transport: Atr1 Is a Main Boron Exporter in Yeast
[作者:Kaya, A; Karakaya, HC; Fomenko, DE; Gladyshev, VN; Koc, A,期刊:Molecular and Cellular Biology, 页码:3665-3674 , 文章类型: Article,,卷期:2009年29-13]
- Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known. To understand boron transport and functions, we screened a yeast genomic DNA library for genes that confer resis...
- Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription
[作者:Yoshitane, H; Takao, T; Satomi, Y; Du, NH; Okano, T; Fukada, Y,期刊:Molecular and Cellular Biology, 页码:3675-3686 , 文章类型: Article,,卷期:2009年29-13]
- In mammalian circadian clockwork, the CLOCK-BMAL1 heterodimer activates E-box-dependent transcription, while its activity is suppressed by circadian binding with negative regulators, such as CRYs. Here, we found that the...
- ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote Transformation
[作者:Sashida, G; Liu, Y; Elf, S; Miyata, Y; Ohyashiki, K; Izumi, M; Menendez, S; Nimer, SD,期刊:Molecular and Cellular Biology, 页码:3687-3699 , 文章类型: Article,,卷期:2009年29-13]
- Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. We found that Elf4/Mef activates Mdm2 expression; thus, lack of or knockdown...
- HIS-24 Linker Histone and SIR-2.1 Deacetylase Induce H3K27me3 in the Caenorhabditis elegans Germ Line
[作者:Wirth, M; Paap, F; Fischle, W; Wenzel, D; Agafonov, DE; Samatov, TR; Wisniewski, JR; Jedrusik-Bode, M,期刊:Molecular and Cellular Biology, 页码:3700-3709 , 文章类型: Article,,卷期:2009年29-13]
- HIS-24 linker histone and SIR-2.1 deacetylase are involved in chromatin silencing in Caenorhabditis elegans. Depletion of SIR-2.1 results in cytoplasmic retention of HIS-24 in oocytes. However, the molecular working mech...
- Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation
[作者:Dodson, LF; Boomer, JS; Deppong, CM; Shah, DD; Sim, J; Bricker, TL; Russell, JH; Green, JM,期刊:Molecular and Cellular Biology, 页码:3710-3721 , 文章类型: Article,,卷期:2009年29-13]
- Despite extensive study, the role of phosphatidylinositol 3-kinase (PI3-kinase) activation in CD28 function has been highly contentious. To definitively address this question, we generated knock-in mice expressing mutati...
- A Twist-Snail Axis Critical for TrkB-Induced Epithelial-Mesenchymal Transition-Like Transformation, Anoikis Resistance, and Metastasis
[作者:Smit, MA; Geiger, TR; Song, JY; Gitelman, I; Peeper, DS,期刊:Molecular and Cellular Biology, 页码:3722-3737 , 文章类型: Article,,卷期:2009年29-13]
- In a genomewide anoikis suppression screen for metastasis genes, we previously identified the neurotrophic receptor tyrosine kinase TrkB. In mouse xenografts, activated TrkB caused highly invasive and metastatic tumors. ...
- The Yeast AAA(+) Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins
[作者:Tessarz, P; Schwarz, M; Mogk, A; Bukau, B,期刊:Molecular and Cellular Biology, 页码:3738-3745 , 文章类型: Article,,卷期:2009年29-13]
- The yeast AAA(+) chaperone Hsp104 is essential for the development of thermotolerance and for the inheritance of prions. Recently, Hsp104, together with the actin cytoskeleton, has been implicated in the asymmetric distr...
- Topoisomerase II alpha Is Required for Embryonic Development and Liver Regeneration in Zebrafish
[作者:Dovey, M; Patton, EE; Bowman, T; North, T; Goessling, W; Zhou, Y; Zon, LI,期刊:Molecular and Cellular Biology, 页码:3746-3753 , 文章类型: Article,,卷期:2009年29-13]
- Topoisomerases solve the topological problems encountered by DNA throughout the lifetime of a cell. Topoisomerase II alpha, which is highly conserved among eukaryotes, untangles replicated chromosomes during mitosis and ...
- The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway
[作者:Sakamoto, S; Aoki, K; Higuchi, T; Todaka, H; Morisawa, K; Tamaki, N; Hatano, E; Fukushima, A; Taniguchi, T; Agata, Y,期刊:Molecular and Cellular Biology, 页码:3754-3769 , 文章类型: Article,,卷期:2009年29-13]
- The positive regulatory machinery in the microRNA (miRNA) processing pathway is relatively well characterized, but negative regulation of the pathway is largely unknown. Here we show that a complex of nuclear factor 90 (...
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