- CXXC Finger Protein 1 Contains Redundant Functional Domains That Support Embryonic Stem Cell Cytosine Methylation, Histone Methylation, and Differentiation
[作者:Tate, CM; Lee, JH; Skalnik, DG,期刊:Molecular and Cellular Biology, 页码:3817-3831 , 文章类型: Article,,卷期:2009年29-14]
- CXXC finger protein 1 (Cfp1) is a regulator of both cytosine methylation and histone methylation. Murine embryonic stem (ES) cells lacking Cfp1 exhibit a decreased plating efficiency, decreased cytosine methylation, elev...
- RelB NF-kappa B Represses Estrogen Receptor alpha Expression via Induction of the Zinc Finger Protein Blimp1
[作者:Wang, XB; Belguise, K; O'Neill, CF; Sanchez-Morgan, N; Romagnoli, M; Eddy, SF; Mineva, ND; Yu, ZY; Min, CY; Trinkaus-Randall, V; Chalbos, D; Sonenshein, GE,期刊:Molecular and Cellular Biology, 页码:3832-3844 , 文章类型: Article,,卷期:2009年29-14]
- Aberrant constitutive expression of NF-kappa B subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in tumorigenesis. Higher RelB subunit expression was demonstrated ...
- Functional Redundancy of Yeast Proteins Reh1 and Rei1 in Cytoplasmic 60S Subunit Maturation
[作者:Parnell, KM; Bass, BL,期刊:Molecular and Cellular Biology, 页码:4014-4023 , 文章类型: Article,,卷期:2009年29-14]
- The biogenesis of the large (60S) ribosomal subunit in eukaryotes involves nucleolar, nucleoplasmic, and cytoplasmic steps. The cytoplasmic protein Rei1, found in all eukaryotes, was previously shown to be necessary for ...
- Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock
[作者:Etchegaray, JP; Machida, KK; Noton, E; Constance, CM; Dallmann, R; Di Napoli, MN; DeBruyne, JP; Lambert, CM; Yu, EA; Reppert, SM; Weaver, DR,期刊:Molecular and Cellular Biology, 页码:3853-3866 , 文章类型: Article,,卷期:2009年29-14]
- Both casein kinase 1 delta (CK1 delta) and epsilon (CK1 epsilon) phosphorylate core clock proteins of the mammalian circadian oscillator. To assess the roles of CK1 delta and CK1 epsilon in the circadian clock mechanism,...
- The Age-Associated Decline of Glycogen Synthase Kinase 3 beta Plays a Critical Role in the Inhibition of Liver Regeneration
[作者:Jin, JL; Wang, GL; Shi, XR; Darlington, GJ; Timchenko, NA,期刊:Molecular and Cellular Biology, 页码:3867-3880 , 文章类型: Article,,卷期:2009年29-14]
- Aging reduces the regenerative capacities of many tissues. In this paper, we show a critical role of the glycogen synthase kinase 3 beta (GSK3 beta)-cyclin D3 pathway in the loss of the regenerative capacity of the liver...
- Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery To Promote Apoptosis in Caenorhabditis elegans
[作者:Shen, QF; Qin, FS; Gao, ZY; Cui, J; Xiao, H; Xu, ZH; Yang, CL,期刊:Molecular and Cellular Biology, 页码:3881-3893 , 文章类型: Article,,卷期:2009年29-14]
In Caenorhabditis elegans, the central cell-killing process is essentially controlled by the interplay of four apoptotic factors: EGL-1/BH3-only protein, CED-9/Bcl2, CED-4/Apaf1, and CED-3/caspase. In cells destined t...
- Histone Acetyltransferase CBP Is Vital To Demarcate Conventional and Innate CD8(+) T-Cell Development
[作者:Fukuyama, T; Kasper, LH; Boussouar, F; Jeevan, T; van Deursen, J; Brindle, PK,期刊:Molecular and Cellular Biology, 页码:3894-3904 , 文章类型: Article,,卷期:2009年29-14]
- Defining the chromatin modifications and transcriptional mechanisms that direct the development of different T-cell lineages is a major challenge in immunology. The transcriptional coactivators CREB binding protein (CBP)...
- The Small Molecule Phenamil Induces Osteoblast Differentiation and Mineralization
[作者:Park, KW; Waki, H; Kim, WK; Davies, BSJ; Young, SG; Parhami, F; Tontonoz, P,期刊:Molecular and Cellular Biology, 页码:3905-3914 , 文章类型: Article,,卷期:2009年29-14]
- Stimulation of osteoblast differentiation from mesenchymal stem cells is a potential strategy for bone repair. Bone morphogenetic proteins (BMPs) that induce osteoblastic differentiation have been successfully used in hu...
- NADPH Oxidase 1 Controls the Persistence of Directed Cell Migration by a Rho-Dependent Switch of alpha 2/alpha 3 Integrins
[作者:Sadok, A; Pierres, A; Dahan, L; Prevot, C; Lehmann, M; Kovacic, H,期刊:Molecular and Cellular Biology, 页码:3915-3928 , 文章类型: Article,,卷期:2009年29-14]
- NADPH oxidase 1 (Nox1) is expressed mainly in colon epithelial cells and produces superoxide ions as a primary function. We showed that Nox1 knockdown inhibits directional persistence of migration on collagen I. This pap...
- The Ability of GAP1(IP4BP) To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb
[作者:Kupzig, S; Bouyoucef-Cherchalli, D; Yarwood, S; Sessions, R; Cullen, PJ,期刊:Molecular and Cellular Biology, 页码:3929-3940 , 文章类型: Article,,卷期:2009年29-14]
- GAP1(IP4BP) is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) that includes GAP1(m), CAPRI, and RASAL. Composed of a central Ras GAP-related domain (RasGRD), surrounded by amino-terminal C2 domains ...
- A Targeted Bypass Screen Identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for Stable U1 snRNP/Pre-mRNA Interaction
[作者:Hage, R; Tung, L; Du, HS; Stands, L; Rosbash, M; Chang, TH,期刊:Molecular and Cellular Biology, 页码:3941-3952 , 文章类型: Article,,卷期:2009年29-14]
- To understand how DEXD/H-box proteins recognize and interact with their cellular substrates, we have been studying Prp28p, a DEXD/H-box splicing factor required for switching the U1 snRNP with the U6 snRNP at the precurs...
- Stxbp4 Regulates Delta Np63 Stability by Suppression of RACK1-Dependent Degradation
[作者:Li, YC; Peart, MJ; Prives, C,期刊:Molecular and Cellular Biology, 页码:3953-3963 , 文章类型: Article,,卷期:2009年29-14]
- p63, a member of the p53 tumor suppressor family, is essential for the development of epidermis as well as other stratified epithelia. Collective evidence indicates that Delta Np63 proteins, the N-terminally deleted vers...
- Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors
[作者:Bodempudi, V; Yamoutpoor, F; Pan, WH; Dudek, AZ; Esfandyari, T; Piedra, M; Babovick-Vuksanovic, D; Woo, RA; Mautner, VF; Kluwe, L; Clapp, DW; DeVries, GH; Thomas, SL; Kurtz, A; Parada, LF; Farassati, F,期刊:Molecular and Cellular Biology, 页码:3964-3974 , 文章类型: Article,,卷期:2009年29-14]
- Ras leads an important signaling pathway that is deregulated in neurofibromatosis type 1 and malignant peripheral nerve sheath tumor (MPNST). In this study, we show that overactivation of Ras and many of its downstream e...
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