- Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues
[作者:Xue, B; Pulinilkunnil, T; Murano, I; Bence, KK; He, H; Minokoshi, Y; Asakura, K; Lee, A; Haj, F; Furukawa, N; Catalano, KJ; Delibegovic, M; Balschi, JA; Cinti, S; Neel, BG; Kahn, BB,期刊:Molecular and Cellular Biology, 页码:4563-4573 , 文章类型: Article,,卷期:2009年29-16]
- PTP1B(-/-) mice are resistant to diet-induced obesity due to leptin hypersensitivity and consequent increased energy expenditure. We aimed to determine the cellular mechanisms underlying this metabolic state. AMPK is an ...
- Dax1 Binds to Oct3/4 and Inhibits Its Transcriptional Activity in Embryonic Stem Cells
[作者:Sun, CH; Nakatake, Y; Akagi, T; Ura, H; Matsuda, T; Nishiyama, A; Koide, H; Ko, MSH; Niwa, H; Yokota, T,期刊:Molecular and Cellular Biology, 页码:4574-4583 , 文章类型: Article,,卷期:2009年29-16]
- Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts. Transcription factor Oct3/4 is an indispensable factor in the self-renewal of ES cells. In this study, we searched for a pr...
- TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, and Survival under DNA-Damaging Conditions
[作者:Schonbrun, M; Laor, D; Lopez-Maury, L; Bahler, J; Kupiec, M; Weisman, R,期刊:Molecular and Cellular Biology, 页码:4584-4594 , 文章类型: Article,,卷期:2009年29-16]
- The Target Of Rapamycin (TOR) kinase belongs to the highly conserved eukaryotic family of phosphatidylinositol-3-kinase-related kinases (PIKKs). TOR proteins are found at the core of two distinct evolutionarily conserved...
- p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21(Cip1) mRNA Mediates the G(1)/S Checkpoint
[作者:Lafarga, V; Cuadrado, A; de Silanes, IL; Bengoechea, R; Fernandez-Capetillo, O; Nebreda, AR,期刊:Molecular and Cellular Biology, 页码:4341-4351 , 文章类型: Article,,卷期:2009年29-16]
- Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in the G(2)/M cell cycle arrest induced by DNA damage, but little is known about the role of this signaling pathway in the G(1)/S transiti...
- Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes
[作者:Outwin, EA; Irmisch, A; Murray, JM; O'Connell, MJ,期刊:Molecular and Cellular Biology, 页码:4363-4375 , 文章类型: Article,,卷期:2009年29-16]
- The function of the essential cohesin-related Smc5-Smc6 complex has remained elusive, though hypomorphic mutants have defects late in recombination, in checkpoint maintenance, and in chromosome segregation. Recombination...
- Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants
[作者:Yang, ZY; Kondo, T; Voorhorst, CS; Nabinger, SC; Ndong, L; Yin, FQ; Chan, EM; Yu, MG; Wurstlin, O; Kratz, CP; Niemeyer, CM; Flotho, C; Hashino, E; Chan, RJ,期刊:Molecular and Cellular Biology, 页码:4376-4393 , 文章类型: Article,,卷期:2009年29-16]
- Juvenile myelomonocytic leukemia (JMML) is characterized by myelomonocytic cell overproduction and commonly bears activating mutations in PTPN11. Murine hematopoietic progenitors expressing activating Shp2 undergo myelom...
- Contributions to Neutropenia from PFAAP5 (N4BP2L2), a Novel Protein Mediating Transcriptional Repressor Cooperation between Gfi1 and Neutrophil Elastase
[作者:Salipante, SJ; Rojas, MEB; Korkmaz, B; Duan, ZJ; Wechsler, J; Benson, KF; Person, RE; Grimes, HL; Horwitz, MS,期刊:Molecular and Cellular Biology, 页码:4394-4405 , 文章类型: Article,,卷期:2009年29-16]
- Neutropenia refers to deficient numbers of neutrophils, the most abundant type of white blood cell. Two main forms of inherited neutropenia are cyclic neutropenia, in which neutrophil counts oscillate with a 21-day frequ...
- Hyphal Chain Formation in Candida albicans: Cdc28-Hgc1 Phosphorylation of Efg1 Represses Cell Separation Genes
[作者:Wang, A; Raniga, PP; Lane, S; Lu, Y; Liu, HP,期刊:Molecular and Cellular Biology, 页码:4406-4416 , 文章类型: Article,,卷期:2009年29-16]
- Cell chain formation is a characteristic of filamentous growth in fungi. How it is regulated developmentally in multimorphic fungi is not known. In Candida albicans, degradation of septa during yeast growth is accomplish...
- Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1
[作者:Kitamura, T; Kitamura, YI; Kobayashi, M; Kikuchi, O; Sasaki, T; DePinho, RA; Accili, D,期刊:Molecular and Cellular Biology, 页码:4417-4430 , 文章类型: Article,,卷期:2009年29-16]
- An understanding of the mechanisms that govern pancreatic endocrine cell ontogeny may offer strategies for their somatic replacement in diabetic patients. During embryogenesis, transcription factor FoxO1 is expressed in ...
- A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation
[作者:Hoffmann, JC; Pappa, A; Krammer, PH; Lavrik, IN,期刊:Molecular and Cellular Biology, 页码:4431-4440 , 文章类型: Article,,卷期:2009年29-16]
- Caspase-8 is the main initiator caspase in death receptor-induced apoptosis. Procaspase-8 is activated at the death-inducing signaling complex (DISC). Previous studies suggested a two-step model of procaspase-8 activatio...
- The Recombination Protein RAD52 Cooperates with the Excision Repair Protein OGG1 for the Repair of Oxidative Lesions in Mammalian Cells
[作者:de Souza-Pinto, NC; Maynard, S; Hashiguchi, K; Hu, JP; Muftuoglu, M; Bohr, VA,期刊:Molecular and Cellular Biology, 页码:4441-4454 , 文章类型: Article,,卷期:2009年29-16]
- Oxidized bases are common types of DNA modifications. Their accumulation in the genome is linked to aging and degenerative diseases. These modifications are commonly repaired by the base excision repair (BER) pathway. Ox...
- A Functional Connection between pRB and Transforming Growth Factor beta in Growth Inhibition and Mammary Gland Development
[作者:Francis, SM; Bergsied, J; Isaac, CE; Coschi, CH; Martens, AL; Hojilla, CV; Chakrabarti, S; DiMattia, GE; Khokha, R; Wang, JYJ; Dick, FA,期刊:Molecular and Cellular Biology, 页码:4455-4466 , 文章类型: Article,,卷期:2009年29-16]
- Transforming growth factor beta (TGF-beta) is a crucial mediator of breast development, and loss of TGF-beta-induced growth arrest is a hallmark of breast cancer. TGF-beta has been shown to inhibit cyclin-dependent kinas...
- Hypoxia-Inducible Factor 1 alpha Induces Fibrosis and Insulin Resistance in White Adipose Tissue
[作者:Halberg, N; Khan, T; Trujillo, ME; Wernstedt-Asterholm, I; Attie, AD; Sherwani, S; Wang, ZV; Landskroner-Eiger, S; Dineen, S; Magalang, UJ; Brekken, RA; Scherer, PE,期刊:Molecular and Cellular Biology, 页码:4467-4483 , 文章类型: Article,,卷期:2009年29-16]
- Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of the vasculature to keep pace with tissue...
- Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation
[作者:Halawani, D; LeBlanc, AC; Rouiller, I; Michnick, SW; Servant, MJ; Latterich, M,期刊:Molecular and Cellular Biology, 页码:4484-4494 , 文章类型: Article,,卷期:2009年29-16]
- Hereditary inclusion body myopathy associated with early-onset Paget disease of bone and frontotemporal dementia (hIBMPFTD) is a degenerative disorder caused by single substitutions in highly conserved residues of p97/VC...
- Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
[作者:Moiseeva, O; Bourdeau, V; Roux, A; Deschenes-Simard, X; Ferbeyre, G,期刊:Molecular and Cellular Biology, 页码:4495-4507 , 文章类型: Article,,卷期:2009年29-16]
- The expression of oncogenic ras in normal human cells quickly induces an aberrant proliferation response that later is curtailed by a cell cycle arrest known as cellular senescence. Here, we show that cells expressing on...
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