- Distinct molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells
[作者：Olejniczak, SH; Blickwedehl, J; Belicha-Villanueva, A; Bangia, N; Riaz, W; Mavis, C; Clements, JL; Gibbs, J; Hernandez-Ilizaliturri, FJ; Czuczman, MS,期刊：Blood, 页码：5605-5614 , 文章类型： Article，,卷期：2010年116-25]
- Resistance to currently available therapies is a major impediment to the successful treatment of hematological malignancies. Here, we used a model of therapy-resistant B-cell nonHodgkin lymphoma (B-NHL) developed in our ...
- Mutation of inhibitory helix-loop-helix protein Id3 causes gamma delta T-cell lymphoma in mice
[作者：Li, J; Maruyama, T; Zhang, P; Konkel, JE; Hoffman, V; Zamarron, B; Chen, WJ,期刊：Blood, 页码：5615-5621 , 文章类型： Article，,卷期：2010年116-25]
- Human gamma delta T-cell lymphoma is a rare clinicopathologic entity with aggressive course and poor prognosis. The etiology and pathogenesis of gamma delta T-cell lymphoma is unknown. We show here that mice with deficie...
- 8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma
[作者：Dennison, JB; Shanmugam, M; Ayres, ML; Qian, J; Krett, NL; Medeiros, LJ; Neelapu, SS; Rosen, ST; Gandhi, V,期刊：Blood, 页码：5622-5630 , 文章类型： Article，,卷期：2010年116-25]
- 8-Aminoadenosine (8-NH2-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt. Given that Akt controls t...
- Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation
[作者：Takeuchi, K; Yokoyama, M; Ishizawa, S; Terui, Y; Nomura, K; Marutsuka, K; Nunomura, M; Fukushima, N; Yagyuu, T; Nakamine, H; Akiyama, F; Hoshi, K; Matsue, K; Hatake, K; Oshimi, K,期刊：Blood, 页码：5631-5637 , 文章类型： Article，,卷期：2010年116-25]
- Diagnostic errors in distinguishing between malignant and reactive processes can cause serious clinical consequences. We report 10 cases of unrecognized self-limited natural killer-cell proliferation in the stomach, desi...
- C/EBP alpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
[作者：Pulikkan, JA; Peramangalam, PS; Dengler, V; Ho, PA; Preudhomme, C; Meshinchi, S; Christopeit, M; Nibourel, O; Muller-Tidow, C; Bohlander, SK; Tenen, DG; Behre, G,期刊：Blood, 页码：5638-5649 , 文章类型： Article，,卷期：2010年116-25]
- The transcription factor, CCAAT enhancer binding protein alpha (C/EBP alpha), is crucial for granulopoiesis and is deregulated by various mechanisms in acute myeloid leukemia (AML). Mutations in the CEBPA gene are report...
- Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group
[作者：Tallman, MS; Kim, HT; Montesinos, P; Appelbaum, FR; de la Serna, J; Bennett, JM; Deben, G; Bloomfield, CD; Gonzalez, J; Feusner, JH; Gonzalez, M; Gallagher, R; Miguel, JDGS; Larson, RA; Milone, G; Paietta, E; Rayon, C; Rowe, JM; Rivas, C; Schiffer, CA; Vellenga, E; Shepherd, L; Slack, JL; Wiernik, PH; Willman, CL; Sanz, MA,期刊：Blood, 页码：5650-5659 , 文章类型： Article，,卷期：2010年116-25]
- Few studies have examined the outcome of large numbers of patients with the microgranular variant (M3V) of acute promyelocytic leukemia (APL) in the all-trans retinoic acid era. Here, the outcome of 155 patients treated ...
- BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
[作者：Schwind, S; Marcucci, G; Maharry, K; Radmacher, MD; Mrozek, K; Holland, KB; Margeson, D; Becker, H; Whitman, SP; Wu, YZ; Metzeler, KH; Powell, BL; Kolitz, JE; Carter, TH; Moore, JO; Baer, MR; Carroll, AJ; Caligiuri, MA; Larson, RA; Bloomfield, CD,期刊：Blood, 页码：5660-5669 , 文章类型： Article，,卷期：2010年116-25]
- BAALC and ERG expression levels are prognostic markers in younger (< 60 years) cytogenetically normal acute myeloid leukemia (CN-AML) adults; their prognostic impact in older (>= 60 years) patients requires further inves...
- Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
[作者：Poirault-Chassac, S; Six, E; Catelain, C; Lavergne, M; Villeval, JL; Vainchenker, W; Lauret, E,期刊：Blood, 页码：5670-5678 , 文章类型： Article，,卷期：2010年116-25]
- The effects of Notch signaling on human megakaryocytic and erythroid differentiation were investigated by exposing human CD34(+) progenitor cells to an immobilized chimeric form of the Notch ligand, Delta-like4 (DII4Fc)....
- Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
[作者：Martinelli, N; Girelli, D; Lunghi, B; Pinotti, M; Marchetti, G; Malerba, G; Pignatti, PF; Corrocher, R; Olivieri, O; Bernardi, F,期刊：Blood, 页码：5688-5697 , 文章类型： Article，,卷期：2010年116-25]
- High levels of coagulation factor VIII (FVIII) have been associated with cardiovascular disease. Low-density lipoprotein receptor (LDLR) has been recently demonstrated to contribute to FVIII clearance from plasma. The ai...
- Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII
[作者：Zheng, CL; Liu, HH; Yuan, SG; Zhou, JH; Zhang, B,期刊：Blood, 页码：5698-5706 , 文章类型： Article，,卷期：2010年116-25]
- The LMAN1-MCFD2 (lectin, mannose binding 1/multiple coagulation factor deficiency protein 2) cargo receptor complex transports coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum (ER) to the ER-Gol...
- Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D
[作者：Wannemacher, KM; Zhu, L; Jiang, H; Fong, KP; Stalker, TJ; Lee, D; Tran, AN; Neeves, KB; Maloney, S; Kumanogoh, A; Kikutani, H; Hammer, DA; Diamond, SL; Brass, LF,期刊：Blood, 页码：5707-5715 , 文章类型： Article，,卷期：2010年116-25]
- We recently reported that Semaphorin 4D (Sema4D) and its receptors are expressed on the platelet surface and showed that Sema4D((-/-)) mice have a selective defect in collagen-induced platelet aggregation and an impaired...
- Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model
[作者：Klement, P; Berry, LR; Liao, P; Wood, H; Tressel, P; Smith, LJ; Haque, N; Weitz, JI; Hirsh, J; Paredes, N; Chan, AKC,期刊：Blood, 页码：5716-5723 , 文章类型： Article，,卷期：2010年116-25]
- Transcranial Doppler-detected high-intensity transient signals (HITS) during cardiopulmonary bypass (CPB) surgery have been associated with postoperative neurocognitive dysfunction, suggesting microemboli in the brain co...
- Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice
[作者：Nordstrom, SM; Holliday, BA; Sos, BC; Smyth, JW; Levy, RE; Dukes, JW; Lord, ST; Weiss, EJ,期刊：Blood, 页码：5724-5733 , 文章类型： Article，,卷期：2010年116-25]
- To explore the effect(s) of growth hormone signaling on thrombosis, we studied signal transduction and transcription factor 5 (STAT5)-deficient mice and found markedly reduced survival in an in vivo thrombosis model. The...
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