- Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe
[作者：Dolmans, MM; Marinescu, C; Saussoy, P; Van Langendonckt, A; Amorim, C; Donnez, J,期刊：Blood, 页码：2908-2914 , 文章类型： Article，,卷期：2010年116-16]
- Ovarian tissue cryopreservation is currently proposed to young cancer patients to preserve their fertility before radiochemotherapy. The potential risk is that the tissue might harbor malignant cells that could induce di...
- Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
[作者：Pulliam-Leath, AC; Ciccone, SL; Nalepa, G; Li, XX; Si, Y; Miravalle, L; Smith, D; Yuan, J; Li, JG; Anur, P; Orazi, A; Vance, GH; Yang, FC; Hanenberg, H; Bagby, GC; Clapp, DW,期刊：Blood, 页码：2915-2920 , 文章类型： Article，,卷期：2010年116-16]
- Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to ...
- Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria
[作者：Stables, MJ; Newson, J; Ayoub, SS; Brown, J; Hyams, CJ; Gilroy, DW,期刊：Blood, 页码：2950-2959 , 文章类型： Article，,卷期：2010年116-16]
- Inhibition of cyclooxygenase (COX)-derived prostaglandins (PGs) by nonsteroidal anti-inflammatory drugs (NSAIDs) mediates leukocyte killing of bacteria. However, the relative contribution of COX1 versus COX2 to this proc...
- RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis
[作者：Satyanarayana, A; Gudmundsson, KO; Chen, X; Coppola, V; Tessarollo, L; Keller, JR; Hou, SX,期刊：Blood, 页码：2921-2931 , 文章类型： Article，,卷期：2010年116-16]
- RapGEF2 is one of many guanine nucleotide exchange factors (GEFs) that specifically activate Rap1. Here, we generated RapGEF2 conditional knockout mice and studied its role in embryogenesis and fetal as well as adult hem...
- An adult uterine hemangioblast: evidence for extramedullary self-renewal and clonal bilineage potential
[作者：Sun, Z; Zhang, YM; Brunt, KR; Wu, J; Li, SH; Fazel, S; Weisel, RD; Keating, A; Li, RK,期刊：Blood, 页码：2932-2941 , 文章类型： Article，,卷期：2010年116-16]
- Stem cells exhibit long-term self-renewal by asymmetric division and multipotent differentiation. During embryonic development, cell fate is determined with predictable orientation, differentiation, and partitioning to f...
- Nonredundant role of CCRL2 in lung dendritic cell trafficking
[作者：Otero, K; Vecchi, A; Hirsch, E; Kearley, J; Vermi, W; Del Prete, A; Gonzalvo-Feo, S; Garlanda, C; Azzolino, O; Salogni, L; Lloyd, CM; Facchetti, F; Mantovani, A; Sozzani, S,期刊：Blood, 页码：2942-2949 , 文章类型： Article，,卷期：2010年116-16]
- Chemokine CC motif receptor-like 2 (CCRL2) is a heptahelic transmembrane receptor that shows the highest degree of homology with CCR1, an inflammatory chemokine receptor. CCRL2 mRNA was rapidly (30 minutes) and transient...
- Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome
[作者：Ortona, E; Capozzi, A; Colasanti, T; Conti, F; Alessandri, C; Longo, A; Garofalo, T; Margutti, P; Misasi, R; Khamashta, MA; Hughes, GRV; Valesini, G; Sorice, M,期刊：Blood, 页码：2960-2967 , 文章类型： Article，,卷期：2010年116-16]
- Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and venous thrombosis, recurrent abortions, and antiphospholipid antibodies (aPL). However, it is possible to find patients with clinical...
- The number of cytomegalovirus-specific CD4(+) T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4(+) T-cell repertoire
[作者：Pourgheysari, B; Bruton, R; Parry, H; Billingham, L; Fegan, C; Murray, J; Moss, P,期刊：Blood, 页码：2968-2974 , 文章类型： Article，,卷期：2010年116-16]
- B-cell chronic lymphocytic leukemia is associated with immune suppression and an altered T-cell repertoire with expansion of memory cells. Cytomegalovirus (CMV) is a common herpes virus that elicits a strong virus-specif...
- LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis
[作者：Gutierrez, A; Tschumper, RC; Wu, XS; Shanafelt, TD; Eckel-Passow, J; Huddleston, PM; Slager, SL; Kay, NE; Jelinek, DF,期刊：Blood, 页码：2975-2983 , 文章类型： Article，,卷期：2010年116-16]
- The canonical Wnt signaling pathway is pathogenic in a variety of cancers. We previously identified aberrant expression of the Wnt pathway transcription factor and target gene lymphoid enhancer binding factor-1 (LEF1) in...
- Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch
[作者：Ding, W; Knox, TR; Tschumper, RC; Wu, WT; Schwager, SM; Boysen, JC; Jelinek, DF; Kay, NE,期刊：Blood, 页码：2984-2993 , 文章类型： Article，,卷期：2010年116-16]
- Malignant cells are capable of influencing the microenvironment in a manner that facilitates tumor cell survival. Bidirectional crosstalk between chronic lymphocytic leukemic (CLL) cells and marrow-derived mesenchymal st...
- Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4(+) T cells
[作者：Swaims, AY; Khani, F; Zhang, YY; Roberts, AI; Devadas, S; Shi, YF; Rabson, AB,期刊：Blood, 页码：2994-3003 , 文章类型： Article，,卷期：2010年116-16]
- Infection with the human T-cell leukemia virus-1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia/lymphoma (ATL). Although the pathogenesis of these disorders is poorly understood, it involves co...
- Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
[作者：Horton, HM; Bernett, MJ; Peipp, M; Pong, E; Karki, S; Chu, SY; Richards, JO; Chen, H; Repp, R; Desjarlais, JR; Zhukovsky, EA,期刊：Blood, 页码：3004-3012 , 文章类型： Article，,卷期：2010年116-16]
- CD40 is highly expressed on various B-lineage malignancies and represents an attractive immunotherapy target for neoplastic disease. Previous work showed that engineering the Fc domain of an antibody for increased bindin...
- Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
[作者：Bachmann, PS; Piazza, RG; Janes, ME; Wong, NC; Davies, C; Mogavero, A; Bhadri, VA; Szymanska, B; Geninson, G; Magistroni, V; Cazzaniga, G; Biondi, A; Miranda-Saavedra, D; Gottgens, B; Saffery, R; Craig, JM; Marshall, GM; Gambacorti-Passerini, C; Pimanda, JE; Lock, RB,期刊：Blood, 页码：3013-3022 , 文章类型： Article，,卷期：2010年116-16]
- Glucocorticoids play a critical role in the therapy of lymphoid malignancies, including pediatric acute lymphoblastic leukemia (ALL), although the mechanisms underlying cellular resistance remain unclear. We report gluco...
- AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
[作者：Santidrian, AF; Gonzalez-Girones, DM; Iglesias-Serret, D; Coll-Mulet, L; Cosialls, AM; de Frias, M; Campas, C; Gonzalez-Barca, E; Alonso, E; Labi, V; Viollet, B; Benito, A; Pons, G; Villunger, A; Gil, J,期刊：Blood, 页码：3023-3032 , 文章类型： Article，,卷期：2010年116-16]
- 5-Aminoimidazole-4-carboxamide riboside or acadesine (AICAR) induces apoptosis in chronic lymphocytic leukemia (CLL) cells. A clinical study of AICAR is currently being performed in patients with this disease. Here, we h...
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