- Dual EGFR/HER2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Withdrawal by Suppressing ErbB3
[作者：Chen, LQ; Mooso, BA; Jathal, MK; Madhav, A; Johnson, SD; van Spyk, E; Mikhailova, M; Zierenberg-Ripoll, A; Xue, LR; Vinall, RL; White, RWD; Ghosh, PM,期刊：Clinical Cancer Research, 页码：6218-6228 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Patients with recurrent prostate cancer are commonly treated with androgen withdrawal therapy (AWT); however, almost all patients eventually progress to castration resistant prostate cancer (CRPC), indicating fa...
- Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation
[作者：Ding, ZB; Hui, B; Shi, YH; Zhou, J; Peng, YF; Gu, CY; Yang, H; Shi, GM; Ke, AW; Wang, XY; Song, K; Dai, Z; Shen, YH; Fan, J,期刊：Clinical Cancer Research, 页码：6229-6238 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Understanding the roles of mammalian autophagy in cancer highlights recent advances in the pharmacologic manipulation of autophagic pathways as a therapeutic strategy for cancer. However, autophagy status and co...
- Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
[作者：Balaguer, F; Moreira, L; Lozano, JJ; Link, A; Ramirez, G; Shen, Y; Cuatrecasas, M; Arnold, M; Meltzer, SJ; Syngal, S; Stoffel, E; Jover, R; Llor, X; Castells, A; Boland, CR; Gironella, M; Goel, A,期刊：Clinical Cancer Research, 页码：6239-6249 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: microRNAs (miRNA) are small noncoding transcripts that play an important role in carcinogenesis. miRNA expression profiles have been shown to discriminate between different types of cancers. The aim of this stud...
- Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype
[作者：Serganova, I; Rizwan, A; Ni, XH; Thakur, SB; Vider, J; Russell, J; Blasberg, R; Koutcher, JA,期刊：Clinical Cancer Research, 页码：6250-6261 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: We compared the metabolic profiles and the association between LDH-A expression and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR and 4T1). These cell lines were derived fro...
- Evaluation of Human Papilloma Virus Diagnostic Testing in Oropharyngeal Squamous Cell Carcinoma: Sensitivity, Specificity, and Prognostic Discrimination
[作者：Schache, AG; Liloglou, T; Risk, JM; Filia, A; Jones, TM; Sheard, J; Woolgar, JA; Helliwell, TR; Triantafyllou, A; Robinson, M; Sloan, P; Harvey-Woodworth, C; Sisson, D; Shaw, RJ,期刊：Clinical Cancer Research, 页码：6262-6271 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Human papillomavirus-16 (HPV16) is the causative agent in a biologically distinct subset of oropharyngeal squamous cell carcinoma (OPSCC) with highly favorable prognosis. In clinical trials, HPV16 status is an e...
- Identification of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer
[作者：Nishino, R; Takano, A; Oshita, H; Ishikawa, N; Akiyama, H; Ito, H; Nakayama, H; Miyagi, Y; Tsuchiya, E; Kohno, N; Nakamura, Y; Daigo, Y,期刊：Clinical Cancer Research, 页码：6272-6286 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: This study aims to identify novel biomarkers and therapeutic targets for lung cancer.Experimental Design: We carried out gene expression profile analysis of 120 lung cancers to screen for genes encoding transmem...
- Disease Flare after Tyrosine Kinase Inhibitor Discontinuation in Patients with EGFR-Mutant Lung Cancer and Acquired Resistance to Erlotinib or Gefitinib: Implications for Clinical Trial Design
[作者：Chaft, JE; Oxnard, GR; Sima, CS; Kris, MG; Miller, VA; Riely, GJ,期刊：Clinical Cancer Research, 页码：6298-6303 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Treatment of patients with oncogene-addicted cancers with tyrosine kinase inhibitors (TKI) is biologically and clinically different than with cytotoxic chemotherapy. We have observed that some patients with EGFR...
- A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors
[作者：Atzori, F; Tabernero, J; Cervantes, A; Prudkin, L; Andreu, J; Rodriguez-Braun, E; Domingo, A; Guijarro, J; Gamez, C; Rodon, J; Di Cosimo, S; Brown, H; Clark, J; Hardwick, JS; Beckman, RA; Hanley, WD; Hsu, K; Calvo, E; Rosello, S; Langdon, RB; Baselga, J,期刊：Clinical Cancer Research, 页码：6304-6312 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a therapeutic target. Dalotuzumab (MK-0646) is a humanized IgG1 monoclonal antibody that binds to IGF...
- A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors
[作者：Tabernero, J; Dirix, L; Schoffski, P; Cervantes, A; Lopez-Martin, JA; Capdevila, J; van Beijsterveldt, L; Platero, S; Hall, B; Yuan, ZL; Knoblauch, R; Zhuang, SH,期刊：Clinical Cancer Research, 页码：6313-6321 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Originally isolated on the basis of its ability to induce p53, serdemetan showed potent activity in various preclinical models, inducing S-phase arrest and apoptosis in TP53 wild-type and mutant tumors. This stu...
- Maintained Sensitivity to EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Lung Cancer Recurring after Adjuvant Erlotinib or Gefitinib
[作者：Oxnard, GR; Janjigian, YY; Arcila, ME; Sima, CS; Kass, SL; Riely, GJ; Pao, W; Kris, MG; Ladanyi, M; Azzoli, CG; Miller, VA,期刊：Clinical Cancer Research, 页码：6322-6328 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Given the unprecedented efficacy of EGFR tyrosine kinase inhibitors (TKI) in advanced EGFR-mutant lung cancer, adjuvant TKI therapy is an appealing strategy. However, there are conflicting findings regarding the...
- Cetuximab Pharmacokinetics Influences Progression-Free Survival of Metastatic Colorectal Cancer Patients
[作者：Azzopardi, N; Lecomte, T; Ternant, D; Boisdron-Celle, M; Piller, F; Morel, A; Gouilleux-Gruart, V; Vignault-Desvignes, C; Watier, H; Gamelin, E; Paintaud, G,期刊：Clinical Cancer Research, 页码：6329-6337 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: An ancillary phase II study was conducted to study interindividual variability in cetuximab pharmacokinetics and its influence on progression-free survival (PFS) in metastatic colorectal cancer patients cotreate...
- KRAS and BRAF Mutation Analysis in Metastatic Colorectal Cancer: A Cost-effectiveness Analysis from a Swiss Perspective
[作者：Blank, PR; Moch, H; Szucs, TD; Schwenkglenks, M,期刊：Clinical Cancer Research, 页码：6338-6346 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Monoclonal antibodies against the epidermal growth factor receptor (EGFR), such as cetuximab, have led to significant clinical benefits for metastatic colorectal cancer (mCRC) patients but have also increased tr...
- A Gene Expression-Based Predictor for Myeloma Patients at High Risk of Developing Bone Disease on Bisphosphonate Treatment
[作者：Wu, P; Walker, BA; Brewer, D; Gregory, WM; Ashcroft, J; Ross, FM; Jackson, GH; Child, AJ; Davies, FE; Morgan, GJ,期刊：Clinical Cancer Research, 页码：6347-6355 , 文章类型： Article，,卷期：2011年17-19]
- Purpose: Myelomabone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE...
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