- Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun
[作者：Itamochi, H; Oishi, T; Shimada, M; Sato, S; Uegaki, K; Naniwa, J; Sato, S; Nonaka, M; Terakawa, N; Kigawa, J; Harada, T,期刊：Clinical Cancer Research, 页码：4742-4750 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: The mTOR pathway is thought to be a central regulator of proliferation and survival of cells. Rapamycin and its analogs are undergoing clinical trials in patients with epithelial ovarian cancer. This study aimed...
- Prospective Analysis of Parametric Response Map-Derived MRI Biomarkers: Identification of Early and Distinct Glioma Response Patterns Not Predicted by Standard Radiographic Assessment
[作者：Galban, CJ; Chenevert, TL; Meyer, CR; Tsien, C; Lawrence, TS; Hamstra, DA; Junck, L; Sundgren, PC; Johnson, TD; Galban, S; Sebolt-Leopold, JS; Rehemtulla, A; Ross, BD,期刊：Clinical Cancer Research, 页码：4751-4760 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Currently, radiologic response of brain tumors is assessed according to the Macdonald criteria 10 weeks from the start of therapy. There exists a critical need to identify nonresponding patients early in the cou...
- Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas
[作者：Jacob, K; Quang-Khuong, DA; Jones, DTW; Witt, H; Lambert, S; Albrecht, S; Witt, O; Vezina, C; Shirinian, M; Faury, D; Garami, M; Hauser, P; Klekner, A; Bognar, L; Farmer, JP; Montes, JL; Atkinson, J; Hawkins, C; Korshunov, A; Collins, VP; Pfister, SM; Tabori, U; Jabado, N,期刊：Clinical Cancer Research, 页码：4650-4660 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK) pathway. Somatic genetic abnormalities affecting this pa...
- Molecular Target Characterization and Antimyeloma Activity of the Novel, Insulin-like Growth Factor 1 Receptor Inhibitor, GTx-134
[作者：Liang, SB; Yang, XZ; Trieu, Y; Li, ZH; Zive, J; Leung-Hagesteijn, C; Wei, E; Zozulya, S; Coss, CC; Dalton, JT; Fantus, IG; Trudel, S,期刊：Clinical Cancer Research, 页码：4693-4704 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Therapeutic strategies that target insulin-like growth factor 1 receptor (IGF-1R) hold promise in a wide variety of cancers including multiple myeloma (MM). In this study, we describe GTx-134, a novel small-mole...
- Engineering the Brain Tumor Microenvironment Enhances the Efficacy of Dendritic Cell Vaccination: Implications for Clinical Trial Design
[作者：Mineharu, Y; King, GD; Muhammad, AKMG; Bannykh, S; Kroeger, KM; Liu, CY; Lowenstein, PR; Castro, MG,期刊：Clinical Cancer Research, 页码：4705-4718 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Clinical trials for GBM using dendritic cell (DC) vaccination resulted in antitumor immune responses. Herein, we tested the hypothesis that combinin...
- MicroRNA-146a Downregulates NF kappa B Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma
[作者：Paik, JH; Jang, JY; Jeon, YK; Kim, WY; Kim, TM; Heo, DS; Kim, CW,期刊：Clinical Cancer Research, 页码：4761-4771 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL). Experimental Design: We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed i...
- NEMO-Binding Domain Peptide Inhibits Constitutive NF-kappa B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma
[作者：Gaurnier-Hausser, A; Patel, R; Baldwin, AS; May, MJ; Mason, NJ,期刊：Clinical Cancer Research, 页码：4661-4671 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive, poorly chemoresponsive lymphoid malignancy characterized by constitutive canonical NF-kappa B activity that promotes lymphomagenesis a...
- MicroRNA Profiling of Sporadic and Hereditary Medullary Thyroid Cancer Identifies Predictors of Nodal Metastasis, Prognosis, and Potential Therapeutic Targets
[作者：Abraham, D; Jackson, N; Gundara, JS; Zhao, JT; Gill, AJ; Delbridge, L; Robinson, BG; Sidhu, SB,期刊：Clinical Cancer Research, 页码：4772-4781 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: While the molecular basis of hereditary medullary thyroid cancer (HMTC) has been well defined, little is known about the molecular pathogenesis of sporadic medullary thyroid cancer (SMTC). In addition, microRNAs...
- Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance
[作者：Carvalho, AL; Henrique, R; Jeronimo, C; Nayak, CS; Reddy, AN; Hoque, MO; Chang, S; Brait, M; Jiang, WW; Kim, MM; Claybourne, Q; Goldenberg, D; Khan, Z; Khan, T; Westra, WH; Sidransky, D; Koch, W; Califano, JA,期刊：Clinical Cancer Research, 页码：4782-4789 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Hypermethylation of tumor suppressor gene promoters has been found in head and neck squamous carcinoma (HNSCC) and other solid tumors. We evaluated these alterations in pretreatment salivary rinses from HNSCC pa...
- Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer
[作者：Chiu, CC; Lin, CY; Lee, LY; Chen, YJ; Lu, YC; Wang, HM; Liao, CT; Chang, JTC; Cheng, AJ,期刊：Clinical Cancer Research, 页码：4629-4641 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: The goal of this study was to establish a common set of molecules that regulate cell invasion in head and neck cancer (HNC). Experimental Design: Five invasive sublines derived from HNC cell lines were establish...
- Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype
[作者：Dziurzynski, K; Wei, J; Qiao, W; Hatiboglu, MA; Kong, LY; Wu, A; Wang, YT; Cahill, D; Levine, N; Prabhu, S; Rao, G; Sawaya, R; Heimberger, AB,期刊：Clinical Cancer Research, 页码：4642-4649 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Cytomegalovirus (CMV) has been ubiquitously detected within high-grade gliomas, but its role in gliomagenesis has not been fully elicited. Experimental Design: Glioblastoma multiforme (GBM) tumors were analyzed ...
- Distinct Apoptotic Signaling Characteristics of the Anti-CD40 Monoclonal Antibody Dacetuzumab and Rituximab Produce Enhanced Antitumor Activity in Non-Hodgkin Lymphoma
[作者：Lewis, TS; McCormick, RS; Emmerton, K; Lau, JT; Yu, SF; McEarchern, JA; Grewal, IS; Law, CL,期刊：Clinical Cancer Research, 页码：4672-4681 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Individually targeting B-cell antigens with monoclonal antibody therapeutics has improved the treatment of non-Hodgkin lymphoma (NHL). We examined if the antitumor activity of rituximab, CD20-specific antibody, ...
- Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation
[作者：Wong, H; Alicke, B; West, KA; Pacheco, P; La, H; Januario, T; Yauch, RL; de Sauvage, FJ; Gould, SE,期刊：Clinical Cancer Research, 页码：4682-4692 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by mutational or ligand-dependent activation of the Hh pathway. W...
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
[作者：Moon, EK; Carpenito, C; Sun, J; Wang, LCS; Kapoor, V; Predina, J; Powell, DJ; Riley, JL; June, CH; Albelda, SM,期刊：Clinical Cancer Research, 页码：4719-4730 , 文章类型： Article，,卷期：2011年17-14]
- Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-modified T cells has yielded dramatic results in some cancers. However, T cells need to traffic properly into tumors to adequately...
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