- Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger
[作者：Liao, J; Li, H; Zeng, WZ; Sauer, DB; Belmares, R; Jiang, YX,期刊：Science, 页码：686-690 , 文章类型： Article，,卷期：2012年335-6069]
- Sodium/calcium (Na+/Ca2+) exchangers (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca2+ for cell signaling. We demonstrated the Na+/Ca2+-exchange function of an N...
- Structure and Allostery of the PKA RII beta Tetrameric Holoenzyme
[作者：Zhang, P; Smith-Nguyen, EV; Keshwani, MM; Deal, MS; Kornev, AP; Taylor, SS,期刊：Science, 页码：712-716 , 文章类型： Article，,卷期：2012年335-6069]
- In its physiological state, cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is a tetramer that contains a regulatory (R) subunit dimer and two catalytic (C) subunits. We describe here the 2.3 angstro...
- Visualizing Long-Term Memory Formation in Two Neurons of the Drosophila Brain
[作者：Chen, CC; Wu, JK; Lin, HW; Pai, TP; Fu, TF; Wu, CL; Tully, T; Chiang, AS,期刊：Science, 页码：678-685 , 文章类型： Article，,卷期：2012年335-6069]
- Long-term memory (LTM) depends on the synthesis of new proteins. Using a temperature-sensitive ribosome-inactivating toxin to acutely inhibit protein synthesis, we screened individual neurons making new proteins after ol...
- Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation
[作者：Song, JK; Teplova, M; Ishibe-Murakami, S; Patel, DJ,期刊：Science, 页码：709-712 , 文章类型： Article，,卷期：2012年335-6069]
- DNMT1, the major maintenance DNA methyltransferase in animals, helps to regulate gene expression, genome imprinting, and X-chromosome inactivation. We report on the crystal structure of a productive covalent mouse DNMT1(...
- Propagation of Slow Slip Leading Up to the 2011 M-w 9.0 Tohoku-Oki Earthquake
[作者：Kato, A; Obara, K; Igarashi, T; Tsuruoka, H; Nakagawa, S; Hirata, N,期刊：Science, 页码：705-708 , 文章类型： Article，,卷期：2012年335-6069]
- Many large earthquakes are preceded by one or more foreshocks, but it is unclear how these foreshocks relate to the nucleation process of the mainshock. On the basis of an earthquake catalog created using a waveform corr...
- Rescued Tolerant CD8 T Cells Are Preprogrammed to Reestablish the Tolerant State
[作者：Schietinger, A; Delrow, JJ; Basom, RS; Blattman, JN; Greenberg, PD,期刊：Science, 页码：723-727 , 文章类型： Article，,卷期：2012年335-6069]
- Tolerant self-antigen-specific CD8 T cells fail to proliferate in response to antigen, thereby preventing autoimmune disease. By using an in vivo mouse model, we show that tolerant T cells proliferate and become function...
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