- Integrin Cytoplasmic Domain-Associated Protein-1 Attenuates Sprouting Angiogenesis
[作者:Brutsch, R; Liebler, SS; Wustehube, J; Bartol, A; Herberich, SE; Adam, MG; Telzerow, A; Augustin, HG; Fischer, A,期刊:Circulation Research, 页码:592-U68 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: The ICAP1 (integrin cytoplasmic domain-associated protein-1) is a specific intracellular binding protein of beta 1-integrins and the cerebral cavernous malformation (CCM) protein CCM1. ICAP1 recruits CCM1 to t...
- CD31(+) Cells Represent Highly Angiogenic and Vasculogenic Cells in Bone Marrow Novel Role of Nonendothelial CD31(+) Cells in Neovascularization and Their Therapeutic Effects on Ischemic Vascular Disease
[作者:Kim, H; Cho, HJ; Kim, SW; Liu, BL; Choi, YJ; Lee, J; Sohn, YD; Lee, MY; Houge, MA; Yoon, YS,期刊:Circulation Research, 页码:602-U106 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: Bone marrow (BM) cells play an important role in physiological and therapeutic neovascularization. However, it remains unclear whether any specific uncultured BM cell populations have higher angiogenic and vas...
- Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging
[作者:Qiu, HY; Zhu, Y; Sun, Z; Trzeciakowski, JP; Gansner, M; Depre, C; Resuello, RRG; Natividad, FF; Hunter, WC; Genin, GM; Elson, EL; Vatner, DE; Meininger, GA; Vatner, SF,期刊:Circulation Research, 页码:615-U117 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objectiv...
- Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited Ca(V)1.2 Channels in Heart
[作者:Xu, XH; Marx, SO; Colecraft, HM,期刊:Circulation Research, 页码:620-U138 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: In heart, Ca2+ entering myocytes via Ca(V)1.2 channels controls essential functions, including excitation-contraction coupling, action potential duration, and gene expression. RGK GTPases (Rad/Rem/Rem2/Gem/Kir...
- Activation of PKN Mediates Survival of Cardiac Myocytes in the Heart During Ischemia/Reperfusion
[作者:Takagi, H; Hsu, CP; Kajimoto, K; Shao, D; Yang, YF; Maejima, Y; Zhai, PY; Yehia, G; Yamada, C; Zablocki, D; Sadoshima, J,期刊:Circulation Research, 页码:642-U196 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: The function of PKN, a stress-activated protein kinase, in the heart is poorly understood. Objective: We investigated the functional role of PKN during myocardial ischemia/reperfusion (I/R). Methods and Result...
- The IP3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli
[作者:Nakayama, H; Bodi, I; Maillet, M; DeSantiago, J; Domeier, TL; Mikoshiba, K; Lorenz, JN; Blatter, LA; Bers, DM; Molkentin, JD,期刊:Circulation Research, 页码:659-U222 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: Inositol 1,4,5-trisphosphate (IP3) is a second messenger that regulates intracellular Ca2+ release through IP3 receptors located in the sarco(endo)plasmic reticulum of cardiac myocytes. Many prohypertrophic G ...
- Role of Cardiac Myocyte CXCR4 Expression in Development and Left Ventricular Remodeling After Acute Myocardial Infarction
[作者:Agarwal, U; Ghalayini, W; Dong, F; Weber, K; Zou, YR; Rabbany, SY; Rafii, S; Penn, MS,期刊:Circulation Research, 页码:667-U236 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: Stromal cell-derived factor (SDF)-1/CXCR4 axis has an instrumental role during cardiac development and has been shown to be a potential therapeutic target for optimizing ventricular remodeling after acute myoc...
- Circulating MicroRNAs in Patients With Coronary Artery Disease
[作者:Fichtlscherer, S; De Rosa, S; Fox, H; Schwietz, T; Fischer, A; Liebetrau, C; Weber, M; Hamm, CW; Roxe, T; Muller-Ardogan, M; Bonauer, A; Zeiher, AM; Dimmeler, S,期刊:Circulation Research, 页码:677-U257 , 文章类型: Article,,卷期:2010年107-5]
- Rationale: MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood. Objective: ...
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