- Precaution, cyclooxygenase inhibition, and cardiovascular risk
[作者:Ritter, JM; Harding, I; Warren, JB,期刊:Trends in Pharmacological Sciences, 页码:503-508 , 文章类型: Review,,卷期:2009年30-10]
- Cardiovascular risk led to the withdrawal of Vioxx (rofecoxib) in 2004. Some related drugs also increase cardiovascular risk and cyclooxygenase (COX)-2 inhibitors that remain on the market, including unselective non-ster...
- Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
[作者:Izzo, AA; Borrelli, F; Capasso, R; Di Marzo, V; Mechoulam, R,期刊:Trends in Pharmacological Sciences, 页码:515-527 , 文章类型: Review,,卷期:2009年30-10]
- Delta(9)-tetrahydrocannabinol binds cannabinoid (CB1 and CB2) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of...
- Is resistance useless? Multidrug resistance and collateral sensitivity
[作者:Hall, MD; Handley, MD; Gottesman, MM,期刊:Trends in Pharmacological Sciences, 页码:546-556 , 文章类型: Review,,卷期:2009年30-10]
- When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide range of cancer drugs; its expression conf...
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