- Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways
[作者：Hassane, DC; Sen, S; Minhajuddin, M; Rossi, RM; Corbett, CA; Balys, M; Wei, LP; Crooks, PA; Guzman, ML; Jordan, CT,期刊：Blood, 页码：5983-5990 , 文章类型： Article，,卷期：2010年116-26]
- We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of thi...
- Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia
[作者：Wang, JY; Liu, YG; Li, ZY; Du, JA; Ryu, MJ; Taylor, PR; Fleming, MD; Young, KH; Pitot, H; Zhang, J,期刊：Blood, 页码：5991-6002 , 文章类型： Article，,卷期：2010年116-26]
- Oncogenic NRAS mutations are frequently identified in myeloid diseases involving monocyte lineage. However, its role in the genesis of these diseases remains elusive. We report a mouse bone marrow transplantation model h...
- Lyn- and PLC-beta 3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
[作者：Xiao, WB; Ando, T; Wang, HY; Kawakami, Y; Kawakami, T,期刊：Blood, 页码：6003-6013 , 文章类型： Article，,卷期：2010年116-26]
- Hyperactivation of the transcription factor Stat5 leads to various leukemias. Stat5 activity is regulated by the protein phosphatase SHP-1 in a phospholipase C (PLC)-beta 3-dependent manner. Thus, PLC-beta 3-deficient mi...
- EVI-1 oncogene expression predicts survival in chronic-phase CML patients resistant to imatinib treated with second-generation tyrosine kinase inhibitors
[作者：Daghistani, M; Marin, D; Khorashad, JS; Wang, LH; May, PC; Paliompeis, C; Milojkovic, D; De Melo, VA; Gerrard, G; Goldman, JM; Apperley, JF; Clark, RE; Foroni, L; Reid, AG,期刊：Blood, 页码：6014-6017 , 文章类型： Article，,卷期：2010年116-26]
- Activation of the EVI-1 oncogene has been reported in acute myeloid leukemia, chronic myeloid leukemia (CML) in blast crisis, and less commonly, in chronic-phase CML patients. We screened an unselected cohort of 75 chron...
- Clinical and genetic features of therapy-related myeloid neoplasms after chemotherapy for acute promyelocytic leukemia
[作者：Imagawa, J; Harada, Y; Shimomura, T; Tanaka, H; Okikawa, Y; Hyodo, H; Kimura, A; Harada, H,期刊：Blood, 页码：6018-6022 , 文章类型： Article，,卷期：2010年116-26]
- Acute promyelocytic leukemia (APL) is a highly curable disease with excellent complete remission and long-term survival rates. However, the development of therapy-related myeloid neoplasms (t-MN) is being reported with i...
- Preferential nuclear accumulation of JAK2V617F in CD34(+) but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia
[作者：Rinaldi, CR; Rinaldi, P; Alagia, A; Gemei, M; Esposito, N; Formiggini, F; Martinelli, V; Senyuk, V; Nucifora, G; Pane, F,期刊：Blood, 页码：6023-6026 , 文章类型： Article，,卷期：2010年116-26]
- Recently, Dawson et al identified a previously unrecognized nuclear role of JAK2 in the phosphorylation of histone H3 in hematopoietic cell lines. We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted ...
- The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils
[作者：Boussetta, T; Gougerot-Pocidalo, MA; Hayem, G; Ciappelloni, S; Raad, H; Derkawi, RA; Bournier, O; Kroviarski, Y; Zhou, XZ; Malter, JS; Lu, PK; Bartegi, A; Dang, PMC; El-Benna, J,期刊：Blood, 页码：5795-5802 , 文章类型： Article，,卷期：2010年116-26]
- Neutrophils play a key role in host defense by releasing reactive oxygen species ( ROS). However, excessive ROS production by neutrophil nicotinamide adenine dinucleotide phosphate ( NADPH) oxidase can damage bystander t...
- Advances in the 5q- syndrome
[作者：Boultwood, J; Pellagatti, A; McKenzie, ANJ; Wainscoat, JS,期刊：Blood, 页码：5803-5811 , 文章类型： Review，,卷期：2010年116-26]
- The 5q- syndrome is the most distinct of all the myelodysplastic syndromes with a clear genotype/phenotype relationship. The significant progress made during recent years has been based on the determination of the common...
- Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency
[作者：Jalagadugula, G; Mao, GF; Kaur, G; Goldfinger, LE; Dhanasekaran, DN; Rao, AK,期刊：Blood, 页码：6037-6045 , 文章类型： Article，,卷期：2010年116-26]
- Mutations in transcription factor RUNX1 are associated with familial platelet disorder, thrombocytopenia, and predisposition to leukemia. We have described a patient with thrombocytopenia and impaired agonist-induced pla...
- Heparin modifies the immunogenicity of positively charged proteins
[作者：Chudasama, SL; Espinasse, B; Hwang, F; Qi, R; Joglekar, M; Afonina, G; Wiesner, MR; Welsby, IJ; Ortel, TL; Arepally, GM,期刊：Blood, 页码：6046-6053 , 文章类型： Article，,卷期：2010年116-26]
- The immune response in heparin-induced thrombocytopenia is initiated by and directed to large multimolecular complexes of platelet factor 4 (PF4) and heparin (H). We have previously shown that PF4:H multimolecular comple...
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