- High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia
[作者:de Jonge, HJM; Valk, PJM; Veeger, NJGM; ter Elst, A; den Boer, ML; Cloos, J; de Haas, V; van den Heuvel-Eibrink, MM; Kaspers, GJL; Zwaan, CM; Kamps, WA; Lowenberg, B; de Bont, ESJM,期刊:Blood, 页码:1747-1754 , 文章类型: Article,,卷期:2010年116-10]
- High VEGFC mRNA expression of acute myeloid leukemia (AML) blasts is related to increased in vitro and in vivo drug resistance. Prognostic significance of VEGFC on long-term outcome and its associated gene expression pro...
- Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma
[作者:Strothmeyer, AM; Papaioannou, D; Duhren-von Minden, M; Navarrete, M; Zirlik, K; Heining-Mikesch, K; Veelken, H,期刊:Blood, 页码:1734-1736 , 文章类型: Article,,卷期:2010年116-10]
- Active immunization with the idiotype of follicular lymphoma induces tumor-specific immunity. T cells induced in vivo by idiotype vaccination recognize human leukocyte antigen (HLA)-restricted hypervariable but not conse...
- Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC
[作者:Liu, XJ; Wang, YQ; Benaissa, S; Matsuda, A; Kantarjian, H; Estrov, Z; Plunkett, W,期刊:Blood, 页码:1737-1746 , 文章类型: Article,,卷期:2010年116-10]
- The nucleoside analog 2'-C-cyano-2'-deoxy- 1-beta-D-arabino-pentofuranosylcytosine (CNDAC), currently in clinical trials for hematologic malignancies, has a novel action mechanism of causing a single-strand break after i...
- Platelet senescence is regulated by an internal timer, not damage inflicted by hits
[作者:Dowling, MR; Josefsson, EC; Henley, KJ; Hodgkin, PD; Kile, BT,期刊:Blood, 页码:1776-1778 , 文章类型: Article,,卷期:2010年116-10]
- The mechanisms responsible for the brief life span of blood platelets have been a subject of speculation since the 1950s. The most popular hypothesis to date has been the "multiple-hit" model, whereby damage inflicted by...
- Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease
[作者:De Ravin, SS; Zarember, KA; Long-Priel, D; Chan, KC; Fox, SD; Gallin, JI; Kuhns, DB; Malech, HL,期刊:Blood, 页码:1755-1760 , 文章类型: Article,,卷期:2010年116-10]
- In chronic granulomatous disease (CGD), defective phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity causes reduced superoxide anion (O-2(sic)) radical production leading to frequent infectio...
- ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing
[作者:Bender, M; Eckly, A; Hartwig, JH; Elvers, M; Pleines, I; Gupta, S; Krohne, G; Jeanclos, E; Gohla, A; Gurniak, C; Gachet, C; Witke, W; Nieswandt, B,期刊:Blood, 页码:1767-1775 , 文章类型: Article,,卷期:2010年116-10]
- The cellular and molecular mechanisms orchestrating the complex process by which bone marrow megakaryocytes form and release platelets remain poorly understood. Mature megakaryocytes generate long cytoplasmic extensions,...
- Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study
[作者:Bethge, WA; Lange, T; Meisner, C; von Harsdorf, S; Bornhaeuser, M; Federmann, B; Stadler, M; Uharek, L; Stelljes, M; Knop, S; Wulf, G; Trenschel, R; Vucinic, V; Dittmann, H; Faul, C; Vogel, W; Kanz, L; Bunjes, D,期刊:Blood, 页码:1795-1802 , 文章类型: Article,,卷期:2010年116-10]
- Forty patients were enrolled in this phase 2 study combining radioimmunotherapy (RIT) using yttrium-90-ibritu-momab-tiuxetan (15 MBq [ 0.4 mCi]/kg) with reduced-intensity conditioning (RIC) using fludarabine (90 mg/m(2))...
- Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa
[作者:Khan, FM; Sy, S; Louie, P; Ugarte-Torres, A; Berka, N; Sinclair, GD; Stewart, DA; Russell, JA; Storek, J,期刊:Blood, 页码:1803-1806 , 文章类型: Article,,卷期:2010年116-10]
- Genomic instability (GI) of cells may lead to their malignant transformation. Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined ...
- GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
[作者:Chang, JS; Patton, JT; Sarkar, A; Ernst, B; Magnani, JL; Frenette, PS,期刊:Blood, 页码:1779-1786 , 文章类型: Article,,卷期:2010年116-10]
- Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of sickle cell disease. Notably, polymorphonuclear neutrophils (PMNs) can capture circulating sic...
- Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis
[作者:White, TA; Johnson, T; Zarzhevsky, N; Tom, C; Delacroix, S; Holroyd, EW; Maroney, SA; Singh, R; Pan, SC; Fay, WP; van Deursen, J; Mast, AE; Sandhu, GS; Simari, RD,期刊:Blood, 页码:1787-1794 , 文章类型: Article,,卷期:2010年116-10]
- The antithrombotic surface of endothelium is regulated in a coordinated manner. Tissue factor pathway inhibitor (TFPI) localized at the endothelial cell surface regulates the production of FXa by inhibiting the TF/VIIa c...
- Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells
[作者:Valentijn, KM; van Driel, LF; Mourik, MJ; Hendriks, GJ; Arends, TJ; Koster, AJ; Valentijn, JA,期刊:Blood, 页码:1807-1816 , 文章类型: Article,,卷期:2010年116-10]
- Regulated exocytosis of Weibel-Palade bodies (WPBs) is a pivotal mechanism via which vascular endothelial cells initiate repair in response to injury and inflammation. Several pathways have been proposed to enable differ...
- Defining response criteria in CLL patients treated in clinical research trials Response
[作者:Hallek, M; Cheson, BD; Catovsky, D; Caligaris-Cappio, F; Dighiero, G; Dohner, H; Hillmen, P; Keating, MJ; Montserrat, E; Rai, KR; Kipps, TJ,期刊:Blood, 页码:1817-1818 , 文章类型: Letter,,卷期:2010年116-10]
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