- Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation
[作者:Divito, SJ; Wang, ZL; Shufesky, WJ; Liu, QA; Tkacheva, OA; Montecalvo, A; Erdos, G; Larregina, AT; Morelli, AE,期刊:Blood, 页码:2694-2705 , 文章类型: Article,,卷期:2010年116-15]
- The prevailing idea regarding the mechanism(s) by which therapeutic immunosuppressive dendritic cells (DCs) restrain alloimmunity is based on the concept that they interact directly with antidonor T cells, inducing anerg...
- Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
[作者:Gammill, HS; Guthrie, KA; Aydelotte, TM; Waldorf, KMA; Nelson, JL,期刊:Blood, 页码:2706-2712 , 文章类型: Article,,卷期:2010年116-15]
- Small amounts of genetically foreign cells (microchimerism, Mc) traffic between a mother and fetus during pregnancy. Commonly, these grafts durably persist. For women, multiple naturally acquired Mc grafts can accrue, as...
- Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia
[作者:Martins, LR; Lucio, P; Silva, MC; Anderes, KL; Gameiro, P; Silva, MG; Barata, JT,期刊:Blood, 页码:2724-2731 , 文章类型: Article,,卷期:2010年116-15]
- Expression of protein kinase CK2 is frequently deregulated in cancer and mounting evidence implicates CK2 in tumorigenesis. Here, we show that CK2 is overexpressed and hyperactivated in chronic lymphocytic leukemia (CLL)...
- High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine
[作者:Bachas, C; Schuurhuis, GJ; Hollink, IHIM; Kwidama, ZJ; Goemans, BF; Zwaan, CM; van den Heuvel-Eibrink, MM; de Bont, ESJM; Reinhardt, D; Creutzig, U; de Haas, V; Assaraf, YG; Kaspers, GJL; Cloos, J,期刊:Blood, 页码:2752-2758 , 文章类型: Article,,卷期:2010年116-15]
- Although virtually all pediatric patients with acute myeloid leukemia (AML) achieve a complete remission after initial induction therapy, 30%-40% of patients will encounter a relapse and have a dismal prognosis. To preve...
- Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound beta-phenylethyl isothiocyanate
[作者:Hu, YM; Lu, WQ; Chen, G; Zhang, H; Jia, Y; Wei, Y; Yang, H; Zhang, W; Fiskus, W; Bhalla, K; Keating, M; Huang, P; Garcia-Manero, G,期刊:Blood, 页码:2732-2741 , 文章类型: Article,,卷期:2010年116-15]
- Mechanisms of action and resistance of histone deacetylase inhibitors (HDACIs) are not well understood. A gene expression analysis performed in a phase 1 trial of vorinostat in leukemia indicated that overexpression of g...
- Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not otherwise specified" (AML-NOS) or "AML with myelodysplasia-related changes" (AML-MRC)
[作者:Miesner, M; Haferlach, C; Bacher, U; Weiss, T; Macijewski, K; Kohlmann, A; Klein, HU; Dugas, M; Kern, W; Schnittger, S; Haferlach, T,期刊:Blood, 页码:2742-2751 , 文章类型: Article,,卷期:2010年116-15]
- The World Health Organization classification of acute myeloid leukemia (AML) is hierarchically structured and integrates genetics, data on patients' history, and multilineage dysplasia (MLD). The category "AML with myelo...
- The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
[作者:Green, CL; Evans, CM; Hills, RK; Burnett, AK; Linch, DC; Gale, RE,期刊:Blood, 页码:2779-2782 , 文章类型: Article,,卷期:2010年116-15]
- Mutations in the isocitrate dehydrogenase gene (IDH1) were recently described in patients with acute myeloid leukemia (AML). To investigate their prognostic significance we determined IDH1 status in 1333 young adult pati...
- Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
[作者:Yokoyama, T; Kanno, Y; Yamazaki, Y; Takahara, T; Miyata, S; Nakamura, T,期刊:Blood, 页码:2768-2775 , 文章类型: Article,,卷期:2010年116-15]
- Trib1 is a myeloid oncogene that cooperates with Hoxa9 and Meis1. Although the MAPK pathway and C/EBP transcription factors are known to interact with Trib proteins, the mechanisms by which Trib1 contributes to myeloid l...
- The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34(+) cells
[作者:Engler, JR; Frede, A; Saunders, V; Zannettino, A; White, DL; Hughes, TP,期刊:Blood, 页码:2776-2778 , 文章类型: Article,,卷期:2010年116-15]
- The functional activity of the organic cation transporter 1 (OCT-1) protein in chronic myeloid leukemia (CML) mononuclear cells (MNCs) is highly predictive of molecular response in imatinib treated patients. Here we inve...
- Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome
[作者:Jun, HS; Lee, YM; Cheung, YY; McDermott, DH; Murphy, PM; De Ravin, SS; Mansfield, BC; Chou, JY,期刊:Blood, 页码:2783-2792 , 文章类型: Article,,卷期:2010年116-15]
- G6PC3 deficiency, characterized by neutropenia and neutrophil dysfunction, is caused by deficiencies in the endoplasmic reticulum (ER) enzyme glucose-6-phosphatase-beta(G6Pase-beta or G6PC3) that converts glucose-6-phosp...
- Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
[作者:McDermott, DH; De Ravin, SS; Jun, HS; Liu, QA; Priel, DAL; Noel, P; Takemoto, CM; Ojode, T; Paul, SM; Dunsmore, KP; Hilligoss, D; Marquesen, M; Ulrick, J; Kuhns, DB; Chou, JY; Malech, HL; Murphy, PM,期刊:Blood, 页码:2793-2802 , 文章类型: Article,,卷期:2010年116-15]
- Mutations in more than 15 genes are now known to cause severe congenital neutropenia (SCN); however, the pathologic mechanisms of most genetic defects are not fully defined. Deficiency of G6PC3, a glucose-6-phosphatase, ...
- Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q(-) polycythemia vera
[作者:Perna, F; Gurvich, N; Hoya-Arias, R; Abdel-Wahab, O; Levine, RL; Asai, T; Voza, F; Menendez, S; Wang, L; Liu, F; Zhao, XY; Nimer, SD,期刊:Blood, 页码:2812-2821 , 文章类型: Article,,卷期:2010年116-15]
- L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia...
- Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait
[作者:Swensen, JJ; Agarwal, AM; Esquilin, JM; Swierczek, S; Perumbeti, A; Hussey, D; Lee, M; Joiner, CH; Pont-Kingdon, G; Lyon, E; Prchal, JT,期刊:Blood, 页码:2822-2825 , 文章类型: Article,,卷期:2010年116-15]
- Sickle cell disease (SCD) is a classic example of a disorder with recessive Mendelian inheritance, in which each parent contributes one mutant allele to an affected offspring. However, there are exceptions to that rule. ...
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