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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共25条记录   Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells [作者：Chiarle, R; Zhang, Y; Frock, RL; Lewis, SM; Molinie, B; Ho, YJ; Myers, DR; Choi, VW; Compagno, M; Malkin, DJ; Neuberg, D; Monti, S; Giallourakis, CC; Gostissa, M; Alt, FW,期刊：Cell, 页码：107-119 , 文章类型： Article，,卷期：2011年147-1] Whereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote them are poorly understood. To elucidate translocation mechanisms in mammalian cells, we developed high-throughput, gen... Genomics in Africa: Avoiding Past Pitfalls [作者：Kaplan, M,期刊：Cell, 页码：11-13 , 文章类型： Editorial Material，,卷期：2011年147-1] A landmark genomics project is taking shape in Africa that shifts the power and prominence to local scientists. If successful, the program will offer valuable insights into the inheritance of common diseases and reshape ... A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells [作者：Fong, YW; Inouye, C; Yamaguchi, T; Cattoglio, C; Grubisic, I; Tjian, R,期刊：Cell, 页码：120-131 , 文章类型： Article，,卷期：2011年147-1] The transcriptional activators Oct4, Sox2, and Nanog cooperate with a wide array of cofactors to orchestrate an embryonic stem (ES) cell-specific gene expression program that forms the molecular basis of pluripotency. He... An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [作者：Gabut, M; Samavarchi-Tehrani, P; Wang, XC; Slobodeniuc, V; O'Hanlon, D; Sung, HK; Alvarez, M; Talukder, S; Pan, Q; Mazzoni, EO; Nedelec, S; Wichterle, H; Woltjen, K; Hughes, TR; Zandstra, PW; Nagy, A; Wrana, JL; Blencowe, BJ,期刊：Cell, 页码：132-146 , 文章类型： Article，,卷期：2011年147-1] Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. Here, we identify an evolutionarily conserved embryonic stem cell (ESC)-specific AS event ... Genomics Reaches the Clinic: From Basic Discoveries to Clinical Impact [作者：Manolio, TA; Green, ED,期刊：Cell, 页码：14-16 , 文章类型： Editorial Material，,卷期：2011年147-1] Today, more than ever, basic science research provides significant opportunities to advance our understanding about the genetic basis of human disease. Close interactions among laboratory, computational, and clinical res... Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli [作者：Vesper, O; Amitai, S; Belitsky, M; Byrgazov, K; Kaberdina, AC; Engelberg-Kulka, H; Moll, I,期刊：Cell, 页码：147-157 , 文章类型： Article，,卷期：2011年147-1] Escherichia coli (E. coli) mazEF is a stress-induced toxin-antitoxin (TA) module. The toxin MazF is an endoribonuclease that cleaves single-stranded mRNAs at ACA sequences. Here, we show that MazF cleaves at ACA sites at... Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis [作者：Matos, J; Blanco, MG; Maslen, S; Skehel, JM; West, SC,期刊：Cell, 页码：158-172 , 文章类型： Article，,卷期：2011年147-1] The efficient and timely resolution of DNA recombination intermediates is essential for bipolar chromosome segregation. Here, we show that the specialized chromosome segregation patterns of meiosis and mitosis, which req... Genetics and Genomics to the Clinic: A Long Road ahead [作者：Ginsburg, D,期刊：Cell, 页码：17-19 , 文章类型： Editorial Material，,卷期：2011年147-1] Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief ... Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation [作者：Holzer, RG; Park, EJ; Li, N; Tran, H; Chen, M; Choi, C; Solinas, G; Karin, M,期刊：Cell, 页码：173-184 , 文章类型： Article，,卷期：2011年147-1] Saturated fatty acids (FA) exert adverse health effects and are more likely to cause insulin resistance and type 2 diabetes than unsaturated FA, some of which exert protective and beneficial effects. Saturated FA, but no... Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity [作者：Haque, A; Andersen, JN; Salmeen, A; Barford, D; Tonks, NK,期刊：Cell, 页码：185-198 , 文章类型： Article，,卷期：2011年147-1] Protein tyrosine phosphatase 1B (PTP1B) plays important roles in downregulation of insulin and leptin signaling and is an established therapeutic target for diabetes and obesity. PTP1B is regulated by reactive oxygen spe... Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium [作者：Whorton, MR; MacKinnon, R,期刊：Cell, 页码：199-208 , 文章类型： Article，,卷期：2011年147-1] G protein-gated K(+) channels (Kir3.1-Kir3.4) control electrical excitability in many different cells. Among their functions relevant to human physiology and disease, they regulate the heart rate and govern a wide range ... Translocation Mapping Exposes the Risky Lifestyle of B Cells [作者：McCord, RP; Dekker, J,期刊：Cell, 页码：20-22 , 文章类型： Editorial Material，,卷期：2011年147-1] Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form fro... A Pseudoatomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke [作者：Chappie, JS; Mears, JA; Fang, SM; Leonard, M; Schmid, SL; Milligan, RA; Hinshaw, JE; Dyda, F,期刊：Cell, 页码：209-222 , 文章类型： Article，,卷期：2011年147-1] The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific structural interactions and conformational changes that drive this process remain a mystery. We... Splicing up Pluripotency [作者：Graveley, BR,期刊：Cell, 页码：22-24 , 文章类型： Editorial Material，,卷期：2011年147-1] In this issue of Cell, Gabut and colleagues (2011) identify a new splice variant of FOXP1 that directly regulates the expression of pluripotency genes. It endows human embryonic stem cells with their pluripotent nature a... Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 [作者：Liu, JL; Xia, HG; Kim, M; Xu, LH; Li, Y; Zhang, LH; Cai, Y; Norberg, HV; Zhang, T; Furuya, T; Jin, MZ; Zhu, ZM; Wang, HC; Yu, J; Li, YX; Hao, Y; Choi, A; Ke, HM; Ma, DW; Yuan, JY,期刊：Cell, 页码：223-234 , 文章类型： Article，,卷期：2011年147-1] Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific an... Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits [作者：Penagarikano, O; Abrahams, BS; Herman, EI; Winden, KD; Gdalyahu, A; Dong, HM; Sonnenblick, LI; Gruver, R; Almajano, J; Bragin, A; Golshani, P; Trachtenberg, JT; Peles, E; Geschwind, DH,期刊：Cell, 页码：235-246 , 文章类型： Article，,卷期：2011年147-1] Although many genes predisposing to autism spectrum disorders (ASD) have been identified, the biological mechanism(s) remain unclear. Mouse models based on human disease-causing mutations provide the potential for unders...