- Development and Evolution of the Human Neocortex
[作者：Lui, JH; Hansen, DV; Kriegstein, AR,期刊：Cell, 页码：18-36 , 文章类型： Review，,卷期：2011年146-1]
- The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and ...
- Gaucher Disease Glucocerebrosidase and alpha-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
[作者：Mazzulli, JR; Xu, YH; Sun, Y; Knight, AL; McLean, PJ; Caldwell, GA; Sidransky, E; Grabowski, GA; Krainc, D,期刊：Cell, 页码：37-52 , 文章类型： Article，,卷期：2011年146-1]
- Parkinson's disease (PD), an adult neurodegenerative disorder, has been clinically linked to the lysosomal storage disorder Gaucher disease (GD), but the mechanistic connection is not known. Here, we show that functional...
- Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2
[作者：Eyler, CE; Wu, QL; Yan, K; MacSwords, JM; Chandler-Militello, D; Misuraca, KL; Lathia, JD; Forrester, MT; Lee, J; Stamler, JS; Goldman, SA; Bredel, M; McLendon, RE; Sloan, AE; Hjelmeland, AB; Rich, JN,期刊：Cell, 页码：53-66 , 文章类型： Article，,卷期：2011年146-1]
- Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this disease. As in other cancers, recent studies have identified ...
- Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair
[作者：Cortellino, S; Xu, JF; Sannai, M; Moore, R; Caretti, E; Cigliano, A; Le Coz, M; Devarajan, K; Wessels, A; Soprano, D; Abramowitz, LK; Bartolomei, MS; Rambow, F; Bassi, MR; Bruno, T; Fanciulli, M; Renner, C; Klein-Szanto, AJ; Matsumoto, Y; Kobi, D; Davidson, I; Alberti, C; Larue, L; Bellacosa, A,期刊：Cell, 页码：67-79 , 文章类型： Article，,卷期：2011年146-1]
- DNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methy...
- Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases
[作者：Heller, RC; Kang, S; Lam, WM; Chen, S; Chan, CS; Bell, SP,期刊：Cell, 页码：80-91 , 文章类型： Article，,卷期：2011年146-1]
- Proper eukaryotic DNA replication requires temporal separation of helicase loading from helicase activation and replisome assembly. Using an in vitro assay for eukaryotic origin-dependent replication initiation, we inves...
- Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors
[作者：Takahashi, H; Parmely, TJ; Sato, S; Tomomori-Sato, C; Banks, CAS; Kong, SE; Szutorisz, H; Swanson, SK; Martin-Brown, S; Washburn, MP; Florens, L; Seidel, CW; Lin, CQ; Smith, ER; Shilatifard, A; Conaway, RC; Conaway, JW,期刊：Cell, 页码：92-104 , 文章类型： Article，,卷期：2011年146-1]
- Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of paused polymerase into productive elongation has emerged as a major mechanism of transcription activation. Reactivation of paused...
- Building Enhancers from the Ground Up: A Synthetic Biology Approach
[作者：Amit, R; Garcia, HG; Phillips, R; Fraser, SE,期刊：Cell, 页码：105-118 , 文章类型： Article，,卷期：2011年146-1]
- A challenge of the synthetic biology approach is to use our understanding of a system to recreate a biological function with specific properties. We have applied this framework to bacterial enhancers, combining a driver,...
- YY1 Tethers Xist RNA to the Inactive X Nucleation Center
[作者：Jeon, Y; Lee, JT,期刊：Cell, 页码：119-133 , 文章类型： Article，,卷期：2011年146-1]
- The long noncoding Xist RNA inactivates one X chromosome in the female mammal. Current models posit that Xist induces silencing as it spreads along X and recruits Polycomb complexes. However, the mechanisms for Xist load...
- Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex
[作者：Devaraneni, PK; Conti, B; Matsumura, Y; Yang, ZY; Johnson, AE; Skach, WR,期刊：Cell, 页码：134-147 , 文章类型： Article，,卷期：2011年146-1]
- In eukaryotic cells, the ribosome-Sec61 translocon complex (RTC) establishes membrane protein topology by cotranslationally partitioning nascent polypeptides into the cytosol, ER lumen, and lipid bilayer. Using photocros...
- Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
[作者：Goetz, JG; Minguet, S; Navarro-Lerida, I; Lazcano, JJ; Samaniego, R; Calvo, E; Tello, M; Osteso-Ibanez, T; Pellinen, T; Echarri, A; Cerezo, A; Klein-Szanto, AJP; Garcia, R; Keely, PJ; Sanchez-Mateos, P; Cukierman, E; Del Pozo, MA,期刊：Cell, 页码：148-163 , 文章类型： Article，,卷期：2011年146-1]
- Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces generated within the microenvironment and is dependent on extr...
- Assembly of Lamina-Specific Neuronal Connections by Slit Bound to Type IV Collagen
[作者：Xiao, T; Staub, W; Robles, E; Gosse, NJ; Cole, GJ; Baier, H,期刊：Cell, 页码：164-176 , 文章类型： Article，,卷期：2011年146-1]
- The mechanisms that generate specific neuronal connections in the brain are under intense investigation. In zebrafish, retinal ganglion cells project their axons into at least six layers within the neuropil of the midbra...
|