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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Assembling the pieces [作者：[Anon],期刊：NATURE CHEMICAL BIOLOGY, 页码：321-321 , 文章类型： Editorial Material，,卷期：2011年7-6] Social engineering for virtual 'big science' in systems biology [作者：KITANO HIROAKI; GHOSH SAMIK; MATSUOKA YUKIKO,期刊：NATURE CHEMICAL BIOLOGY, 页码：323-326 , 文章类型： Article，,卷期：2011年7-6] An active role for machine learning in drug development [作者：MURPHY ROBERT F,期刊：NATURE CHEMICAL BIOLOGY, 页码：327-330 , 文章类型： Article，,卷期：2011年7-6] A postreductionist framework for protein biochemistry [作者：LAUE TOM; DEMELER BORRIES,期刊：NATURE CHEMICAL BIOLOGY, 页码：331-334 , 文章类型： Article，,卷期：2011年7-6] Getting pharmaceutical R&D back on target [作者：BUNNAGE MARK E,期刊：NATURE CHEMICAL BIOLOGY, 页码：335-339 , 文章类型： Article，,卷期：2011年7-6] RNA FOLDING A tale of two riboswitches [作者：HAMMOND MING C,期刊：NATURE CHEMICAL BIOLOGY, 页码：342-343 , 文章类型： News Item，,卷期：2011年7-6] SIGNAL TRANSDUCTCTION STIM1 senses both Ca2+ and heat [作者：MANCARELLA SALVATORE; WANG YOUJUN; GILL DONALD L,期刊：NATURE CHEMICAL BIOLOGY, 页码：344-345 , 文章类型： News Item，,卷期：2011年7-6] ANTITOXINS Therapy for stressed bacteria [作者：HADJIFRANGISKOU MARIA; KOSTAKIOTI MARIA; HULTGREN SCOTT J,期刊：NATURE CHEMICAL BIOLOGY, 页码：345-347 , 文章类型： News Item，,卷期：2011年7-6] Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy [作者：EJIM LINDA; FARHA MAYA A; FALCONER SHANNON B; WILDENHAIN JAN; COOMBES BRIAN K; TYERS MIKE; BROWN ERIC D; WRIGHT GERARD D,期刊：NATURE CHEMICAL BIOLOGY, 页码：348-350 , 文章类型： Article，,卷期：2011年7-6] Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sa... Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression [作者：XIAO BAILONG; COSTE BERTRAND; MATHUR JAYANTI; PATAPOUTIAN ARDEM,期刊：NATURE CHEMICAL BIOLOGY, 页码：351-358 , 文章类型： Article，,卷期：2011年7-6] Intracellular Ca2+ is essential for diverse cellular functions. Ca2+ entry into many cell types including immune cells is triggered by depleting endoplasmic reticulum ( ER) Ca2+, a process termed store-operated Ca2+ entr... Antitoxin MqsA helps mediate the bacterial general stress response [作者：WANG XIAOXUE; KIM YOUNGHOON; HONG SEOK HOON; MA QUN; BROWN BREANN L; PU MINGMING; TARONE AARON M; BENEDIK MICHAEL J; PETI WOLFGANG; PAGE REBECCA; WOOD THOMAS K,期刊：NATURE CHEMICAL BIOLOGY, 页码：359-366 , 文章类型： Article，,卷期：2011年7-6] n Although it is well recognized that bacteria respond to environmental stress through global networks, the mechanism by which stress is relayed to the interior of the cell is poorly understood. Here we show that enigmat... Single-molecule analysis reveals three phases of DNA degradation by an exonuclease [作者：LEE GWANGROG; YOO JUNGMIN; LESLIE BENJAMIN J; HA TAEKJIP,期刊：NATURE CHEMICAL BIOLOGY, 页码：367-374 , 文章类型： Article，,卷期：2011年7-6] lambda exonuclease degrades one strand of duplex DNA in the 5'-to-3' direction to generate a 3' overhang required for recombination. Its ability to hydrolyze thousands of nucleotides processively is attributed to its rin... A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis [作者：CHIDLEY CHRISTOPHER; HARUKI HIROHITO; PEDERSEN MIRIAM GRONLUND; MULLER EVELYNE; JOHNSSON KAI,期刊：NATURE CHEMICAL BIOLOGY, 页码：375-383 , 文章类型： Article，,卷期：2011年7-6] We introduce an approach for detection of drug-protein interactions that combines a new yeast three-hybrid screening for identification of interactions with affinity chromatography for their unambiguous validation. We ap... Molecular insights into the ligand-controlled organization of the SAM-I riboswitch [作者：HEPPELL BENOIT; BLOUIN SIMON; DUSSAULT ANNEMARIE; MULHBACHER JEROME; ENNIFAR ERIC; PENEDO J CARLOS; LAFONTAINE DANIEL A,期刊：NATURE CHEMICAL BIOLOGY, 页码：384-392 , 文章类型： Article，,卷期：2011年7-6] S-adenosylmethionine (SAM) riboswitches are widespread in bacteria, and up to five different SAM riboswitch families have been reported, highlighting the relevance of SAM regulation. On the basis of crystallographic and ... Conformational capture of the SAM-II riboswitch [作者：HALLER ANDREA; RIEDER ULRIKE; AIGNER MICHAELA; BLANCHARD SCOTT C; MICURA RONALD,期刊：NATURE CHEMICAL BIOLOGY, 页码：393-400 , 文章类型： Article，,卷期：2011年7-6] Riboswitches are gene regulation elements in mRNA that function by specifically responding to metabolites. Although the metabolite-bound states of riboswitches have proven amenable to structure determination efforts, kno...