- Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
[作者：Karube, K; Nakagawa, M; Tsuzuki, S; Takeuchi, I; Honma, K; Nakashima, Y; Shimizu, N; Ko, YH; Morishima, Y; Ohshima, K; Nakamura, S; Seto, M,期刊：Blood, 页码：3195-3204 , 文章类型： Article，,卷期：2011年118-12]
- Oligo-array comparative genomic hybridization (CGH) and gene-expression profiling of natural killer (NK)-cell neoplasms were used in an effort to delineate the molecular pathogenesis involved. Oligoarray CGH identified t...
- Approach to the treatment of multiple myeloma: a clash of philosophies
[作者：Rajkumar, SV; Gahrton, G; Bergsagel, PL,期刊：Blood, 页码：3205-3211 , 文章类型： Article，,卷期：2011年118-12]
- In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many o...
- Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
[作者：Krayenbuehl, PA; Battegay, E; Breymann, C; Furrer, J; Schulthess, G,期刊：Blood, 页码：3222-3227 , 文章类型： Article，,卷期：2011年118-12]
- This is the first study to investigate the efficacy of intravenous iron in treating fatigue in nonanemic patients with low serum ferritin concentration. In a randomized, double-blinded, placebo-controlled study, 90 preme...
- Combination of pegylated IFN-alpha 2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia
[作者：Simonsson, B; Gedde-Dahl, T; Markevarn, B; Remes, K; Stentoft, J; Almqvist, A; Bjoreman, M; Flogegard, M; Koskenvesa, P; Lindblom, A; Malm, C; Mustjoki, S; Myhr-Eriksson, K; Ohm, L; Rasanen, A; Sinisalo, M; Sjalander, A; Stromberg, U; Bjerrum, OW; Ehrencrona, H; Gruber, F; Kairisto, V; Olsson, K; Sandin, F; Nagler, A; Nielsen, JL; Hjorth-Hansen, H; Porkka, K,期刊：Blood, 页码：3228-3235 , 文章类型： Article，,卷期：2011年118-12]
- Biologic and clinical observations suggest that combining imatinib with IFN-alpha may improve treatment outcome in chronic myeloid leukemia (CML). We randomized newly diagnosed chronic-phase CML patients with a low or in...
- IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells
[作者：Huynh, H; Zheng, JK; Umikawa, M; Zhang, CZ; Silvany, R; Iizuka, S; Holzenberger, M; Zhang, W; Zhang, CC,期刊：Blood, 页码：3236-3243 , 文章类型： Article，,卷期：2011年118-12]
- The role of IGF binding protein 2 (IGFBP2) in cell growth is intriguing and largely undefined. Previously we identified IGFBP2 as an extrinsic factor that supports ex vivo expansion of hematopoietic stem cells (HSCs). He...
- Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance
[作者：Hodge, JN; Srinivasula, S; Hu, ZH; Read, SW; Porter, BO; Kim, I; Mican, JM; Paik, C; DeGrange, P; Di Mascio, M; Sereti, I,期刊：Blood, 页码：3244-3253 , 文章类型： Article，,卷期：2011年118-12]
- IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought to be due to increased production by homeostatic feedback, decreased receptor-mediated clea...
- Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery
[作者：Giuliani, M; Oudrhiri, N; Noman, ZM; Vernochet, A; Chouaib, S; Azzarone, B; Durrbach, A; Bennaceur-Griscelli, A,期刊：Blood, 页码：3254-3262 , 文章类型： Article，,卷期：2011年118-12]
- A major issue in immunosuppressive biotherapy is the use of mesenchymal stem cells (MSCs) that harbor regulatory capacity. However, currently used bone marrow-derived MSCs (BM-MSCs) are short-lived and cannot assure long...
- Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders
[作者：Piconi, S; Parisotto, S; Rizzardini, G; Passerini, S; Terzi, R; Argenteri, B; Meraviglia, P; Capetti, A; Biasin, M; Trabattoni, D; Clerici, M,期刊：Blood, 页码：3263-3272 , 文章类型： Article，,卷期：2011年118-12]
- Despite optimal suppression of HIV replication, restoration of CD4(+) T cells is not always achieved in antiretroviral therapy-treated individuals. Defective CD4 recovery in immunologic nonresponders is possibly associat...
- Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
[作者：Curti, A; Ruggeri, L; D'Addio, A; Bontadini, A; Dan, E; Motta, MR; Trabanelli, S; Giudice, V; Urbani, E; Martinelli, G; Paolini, S; Fruet, F; Isidori, A; Parisi, S; Bandini, G; Baccarani, M; Velardi, A; Lemoli, RM,期刊：Blood, 页码：3273-3279 , 文章类型： Article，,卷期：2011年118-12]
- Thirteen patients with acute myeloid leukemia, 5 with active disease, 2 in molecular relapse, and 6 in morphologic complete remission (CR; median age, 62 years; range, 53-73 years) received highly purified CD56(+)CD3(-) ...
- Type I-IFNs control GVHD and GVL responses after transplantation
[作者：Robb, RJ; Kreijveld, E; Kuns, RD; Wilson, YA; Olver, SD; Don, ALJ; Raffelt, NC; De Weerd, NA; Lineburg, KE; Varelias, A; Markey, KA; Koyama, M; Clouston, AD; Hertzog, PJ; MacDonald, KPA; Hill, GR,期刊：Blood, 页码：3399-3409 , 文章类型： Article，,卷期：2011年118-12]
- Although the effects of type II-IFN (IFN-gamma) on GVHD and leukemia relapse are well studied, the effects of type I-interferon (type I-IFN, IFN-alpha/beta) remain unclear. We investigated this using type I-IFN receptor-...
- Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
[作者：Noubade, R; Krementsov, DN; del Rio, R; Thornton, T; Nagaleekar, V; Saligrama, N; Spitzack, A; Spach, K; Sabio, G; Davis, RJ; Rincon, M; Teuscher, C,期刊：Blood, 页码：3290-3300 , 文章类型： Article，,卷期：2011年118-12]
- Although several transcription factors have been shown to be critical for the induction and maintenance of IL-17 expression by CD4 Th cells, less is known about the role of nontranscriptional mechanisms. Here we show tha...
- Dual-functional capability of CD3(+)CD56(+) CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
[作者：Pievani, A; Borleri, G; Pende, D; Moretta, L; Rambaldi, A; Golay, J; Introna, M,期刊：Blood, 页码：3301-3310 , 文章类型： Article，,卷期：2011年118-12]
- CD3(+)CD56(+) cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in binding as well as in cytolytic activity of CI...
- T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets
[作者：Alonso, MN; Wong, MT; Zhang, AL; Winer, D; Suhoski, MM; Tolentino, LL; Gaitan, J; Davidson, MG; Kung, TH; Galel, DM; Nadeau, KC; Kim, J; Utz, PJ; Soderstrom, K; Engleman, EG,期刊：Blood, 页码：3311-3320 , 文章类型： Article，,卷期：2011年118-12]
- Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined mechanisms. Our studies indicate that T(H) cells frequently ...
- Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44(+) mucosal NK cells during SIV infection
[作者：Reeves, RK; Rajakumar, PA; Evans, TI; Connole, M; Gillis, J; Wong, FE; Kuzmichev, YV; Carville, A; Johnson, RP,期刊：Blood, 页码：3321-3330 , 文章类型： Article，,卷期：2011年118-12]
- Natural killer (NK) cells are classically viewed as effector cells that kill virus-infected and neoplastic cells, but recent studies have identified a rare mucosal NK-cell subpopulation secreting the TH17 cytokine IL-22....
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