- Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia
[作者：Ravandi, F; O'Brien, S; Jorgensen, J; Pierce, S; Faderl, S; Ferrajoli, A; Koller, C; Challagundla, P; York, S; Brandt, M; Luthra, R; Burger, J; Thomas, D; Keating, M; Kantarjian, H,期刊：Blood, 页码：3818-3823 , 文章类型： Article，,卷期：2011年118-14]
- We conducted this study to determine the feasibility and safety of cladribine followed by rituximab in patients with hairy cell leukemia including the variant form (HCLv). Cladribine 5.6 mg/m(2) given IV over 2 hours dai...
- Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial
[作者：Braun, T; Itzykson, R; Renneville, A; de Renzis, B; Dreyfus, F; Laribi, K; Bouabdallah, K; Vey, N; Toma, A; Recher, C; Royer, B; Joly, B; Vekhoff, A; Lafon, I; Sanhes, L; Meurice, G; Orear, C; Preudhomme, C; Gardin, C; Ades, L; Fontenay, M; Fenaux, P; Droin, N; Solary, E,期刊：Blood, 页码：3824-3831 , 文章类型： Article，,卷期：2011年118-14]
- Hydroxyurea is the standard therapy of chronic myelomonocytic leukemia (CMML) presenting with advanced myeloproliferative and/or myelodysplastic features. Response to hypomethylating agents has been reported in heterogen...
- A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia
[作者：Lee, JH; Joo, YD; Kim, H; Bae, SH; Kim, MK; Zang, DY; Lee, JL; Lee, GW; Lee, JH; Park, JH; Kim, DY; Lee, WS; Ryoo, HM; Hyun, MS; Kim, HJ; Min, YJ; Jang, YE; Lee, KH,期刊：Blood, 页码：3832-3841 , 文章类型： Article，,卷期：2011年118-14]
- We conducted a phase 3 randomized trial comparing 2 different doses of daunorubicin as induction chemotherapy in young adults (60 years of age or younger) with acute myeloid leukemia (AML). Of 383 patients who were analy...
- Dominant-negative C/ebp alpha and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis
[作者：Zhou, T; Wang, L; Zhu, KY; Dong, M; Xu, PF; Chen, Y; Chen, SJ; Chen, Z; Deng, M; Liu, TX,期刊：Blood, 页码：3842-3852 , 文章类型： Article，,卷期：2011年118-14]
- The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once r...
- PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function
[作者：Zhang, Y; Stehling-Sun, S; Lezon-Geyda, K; Juneja, SC; Coillard, L; Chatterjee, G; Wuertzer, CA; Camargo, F; Perkins, AS,期刊：Blood, 页码：3853-3861 , 文章类型： Article，,卷期：2011年118-14]
- The Mds1 and Evi1 complex locus (Mecom) gives rise to several alternative transcripts implicated in leukemogenesis. However, the contribution that Mecom-derived gene products make to normal hematopoiesis remains largely ...
- The human cytokine TSLP triggers a cell-autonomous dendritic cell migration in confined environments
[作者：Fernandez, MI; Heuze, ML; Martinez-Cingolani, C; Volpe, E; Donnadieu, MH; Piel, M; Homey, B; Lennon-Dumenil, AM; Soumelis, V,期刊：Blood, 页码：3862-3869 , 文章类型： Article，,卷期：2011年118-14]
- Dendritic cells (DCs) need to migrate in the interstitial environment of peripheral tissues to reach secondary lymphoid organs and initiate a suitable immune response. Whether and how inflamed tissues instruct DCs to emi...
- Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection
[作者：Li, S; Choi, HJ; Felio, K; Wang, CR,期刊：Blood, 页码：3870-3878 , 文章类型： Article，,卷期：2011年118-14]
- Group 1 CD1 (CD1a, -b, and -c) presents self and foreign lipid antigens to multiple T-cell subsets in humans. However, in the absence of a suitable animal model, the specific functions and developmental requirements of t...
- Cell-intrinsic role for IFN-alpha-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
[作者：Li, HS; Gelbard, A; Martinez, GJ; Esashi, E; Zhang, HY; Nguyen-Jackson, H; Liu, YJ; Overwijk, WW; Watowich, SS,期刊：Blood, 页码：3879-3889 , 文章类型： Article，,卷期：2011年118-14]
- Plasmacytoid dendritic cells (pDCs) reside in bone marrrow and lymphoid organs in homeostatic conditions and typically secrete abundant quantities of type I interferons (IFNs) on Toll-like receptor triggering. Recently, ...
- IL-12 selectively programs effector pathways that are stably expressed in human CD8(+) effector memory T cells in vivo
[作者：Chowdhury, FZ; Ramos, HJ; Davis, LS; Forman, J; Farrar, JD,期刊：Blood, 页码：3890-3900 , 文章类型： Article，,卷期：2011年118-14]
- CD8(+) cytotoxic T lymphocytes play a major role in defense against intracellular pathogens, and their functions are specified by antigen recognition and innate cytokines. IL-12 and IFN-alpha/beta are potent "signal 3" c...
- ABT-737 is highly effective against molecular subgroups of multiple myeloma
[作者：Bodet, L; Gomez-Bougie, P; Touzeau, C; Dousset, C; Descamps, G; Maiga, S; Avet-Loiseau, H; Bataille, R; Moreau, P; Le Gouill, S; Pellat-Deceunynck, C; Amiot, M,期刊：Blood, 页码：3901-3910 , 文章类型： Article，,卷期：2011年118-14]
- Multiple myeloma is a plasma cell malignancy that is heterogeneous with respect to its causative molecular abnormalities and the treatment response of patients. The Bcl-2 protein family is critical for myeloma cell survi...
- FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma
[作者：Elliott, NE; Cleveland, SM; Grann, V; Janik, J; Waldmann, TA; Dave, UP,期刊：Blood, 页码：3911-3921 , 文章类型： Article，,卷期：2011年118-14]
- Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter ...
- CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity
[作者：Sakakibara, K; Saito, N; Sato, T; Suzuki, A; Hasegawa, Y; Friedman, JM; Kufe, DW; VonHoff, DD; Iwami, T; Kawabe, T,期刊：Blood, 页码：3922-3931 , 文章类型： Article，,卷期：2011年118-14]
- CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong antitumor properties. However, its toxici...
- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
[作者：Jankowska, AM; Makishima, H; Tiu, RV; Szpurka, H; Huang, Y; Traina, F; Visconte, V; Sugimoto, Y; Prince, C; O'Keefe, C; Hsi, ED; List, A; Sekeres, MA; Rao, A; McDevitt, MA; Maciejewski, JP,期刊：Blood, 页码：3932-3941 , 文章类型： Article，,卷期：2011年118-14]
- Chronic myelomonocytic leukemia (CMML), a myelodysplastic/myeloproliferative neoplasm, is characterized by monocytic proliferation, dysplasia, and progression to acute myeloid leukemia. CMML has been associated with soma...
- Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin
[作者：Konings, J; Govers-Riemslag, JWP; Philippou, H; Mutch, NJ; Borissoff, JI; Allan, P; Mohan, S; Tans, G; ten Cate, H; Ariens, RAS,期刊：Blood, 页码：3942-3951 , 文章类型： Article，,卷期：2011年118-14]
- Recent data indicate an important contribution of coagulation factor (F)XII to in vivo thrombus formation. Because fibrin structure plays a key role in clot stability and thrombosis, we hypothesized that FXII(a) interact...
- Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice
[作者：Machlus, KR; Lin, FC; Wolberg, AS,期刊：Blood, 页码：3960-3968 , 文章类型： Article，,卷期：2011年118-14]
- Studies have correlated elevated plasma factor VIII (FVIII) with thrombosis; however, it is unclear whether elevated FVIII is a proinflammatory biomarker, causative agent, or both. We raised FVIII levels in mice and meas...
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