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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG [作者：Ho, PA; Kopecky, KJ; Alonzo, TA; Gerbing, RB; Miller, KL; Kuhn, J; Zeng, R; Ries, RE; Raimondi, SC; Hirsch, BA; Oehler, V; Hurwitz, CA; Franklin, JL; Gamis, AS; Petersdorf, SH; Anderson, JE; Godwin, JE; Reaman, GH; Willman, CL; Bernstein, ID; Radich, JP; Appelbaum, FR; Stirewalt, DL; Meshinchi, S,期刊：Blood, 页码：4561-4566 , 文章类型： Article，,卷期：2011年118-17] IDH1 SNP rs11554137 was recently reported in association with poor prognosis in normal karyotype adult acute myeloid leukemia (AML). We aimed to determine the prevalence, clinical associations, and prognostic significanc... Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib [作者：Cortes, JE; Kantarjian, HM; Brummendorf, TH; Kim, DW; Turkina, AG; Shen, ZX; Pasquini, R; Khoury, HJ; Arkin, S; Volkert, A; Besson, N; Abbas, R; Wang, JY; Leip, E; Gambacorti-Passerini, C,期刊：Blood, 页码：4567-4576 , 文章类型： Article，,卷期：2011年118-17] Bosutinib, a dual Src/Abl kinase inhibitor, has shown potent activity against chronic myeloid leukemia (CML). In this phase 1/2 study we evaluated bosutinib in patients with chronic phase imatinib-resistant or imatinib-i... Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies [作者：Li, Z; Cai, XQ; Cai, CL; Wang, JP; Zhang, WY; Petersen, BE; Yang, FC; Xu, MJ,期刊：Blood, 页码：4509-4518 , 文章类型： Article，,卷期：2011年118-17] TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML. However, little is known regarding the biological function of TET2 and its role in the pathogenes... Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN) [作者：Palumbo, A; Bringhen, S; Ludwig, H; Dimopoulos, MA; Blade, J; Mateos, MV; Rosinol, L; Boccadoro, M; Cavo, M; Lokhorst, H; Zweegman, S; Terpos, E; Davies, F; Driessen, C; Gimsing, P; Gramatzki, M; Hajek, R; Johnsen, HE; Da Costa, FL; Sezer, O; Spencer, A; Beksac, M; Morgan, G; Einsele, H; Miguel, JFS; Sonneveld, P,期刊：Blood, 页码：4519-4529 , 文章类型： Review，,卷期：2011年118-17] Most patients with newly diagnosed multiple myeloma (MM) are aged > 65 years with 30% aged > 75 years. Many elderly patients are also vulnerable because of comorbidities that complicate the management of MM. The prevalen... How I treat patients who mobilize hematopoietic stem cells poorly [作者：To, LB; Levesque, JP; Herbert, KE,期刊：Blood, 页码：4530-4540 , 文章类型： Article，,卷期：2011年118-17] Transplantation with 2-5 x 10(6) mobilized CD34(+) cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a... The achievement of an early complete cytogenetic response is a major determinant for outcome in patients with early chronic phase chronic myeloid leukemia treated with tyrosine kinase inhibitors [作者：Jabbour, E; Kantarjian, H; O'Brien, S; Shan, J; Quintas-Cardama, A; Faderl, S; Garcia-Manero, G; Ravandi, F; Rios, MB; Cortes, J,期刊：Blood, 页码：4541-4546 , 文章类型： Article，,卷期：2011年118-17] We analyzed the association between achievement of early complete cytogenetic response (CCyR) and event-free survival (EFS) and overall survival (OS) in patients with newly diagnosed chronic myeloid leukemia in chronic p... Outcome according to cytogenetic abnormalities and DNA ploidy in myeloma patients receiving short induction with weekly bortezomib followed by maintenance [作者：Mateos, MV; Gutierrez, NC; Martin-Ramos, ML; Paiva, B; Montalban, MA; Oriol, A; Martinez-Lopez, J; Teruel, AI; Bengoechea, E; Martin, A; Diaz-Mediavilla, J; de Arriba, F; Palomera, L; Hernandez, JM; Sureda, A; Bargay, J; Penalver, FJ; Ribera, JM; Martin-Mateos, ML; Fernandez, M; Garcia-Sanz, R; Vidriales, MB; Blade, J; Lahuerta, JJ; San Miguel, JF,期刊：Blood, 页码：4547-4553 , 文章类型： Article，,卷期：2011年118-17] Cytogenetic abnormalities (CAs) such as t(4;14), t(14;16) or del(17p), and nonhyperdiploidy are associated with poor prognosis in multiple myeloma. We evaluated the influence of CAs by FISH and DNA ploidy by flow cytomet... Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population [作者：Efficace, F; Baccarani, M; Breccia, M; Alimena, G; Rosti, G; Cottone, F; Deliliers, GL; Barate, C; Rossi, AR; Fioritoni, G; Luciano, L; Turri, D; Martino, B; Di Raimondo, F; Dabusti, M; Bergamaschi, M; Leoni, P; Simula, MP; Levato, L; Ulisciani, S; Veneri, D; Sica, S; Rambaldi, A; Vignetti, M; Mandelli, F,期刊：Blood, 页码：4554-4560 , 文章类型： Article，,卷期：2011年118-17] The main objective of this study was to investigate whether patients with chronic myeloid leukemia (CML) in treatment with long-term therapy imatinib have a different health-related quality-of-life (HRQOL) profile compar... Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol [作者：Trottestam, H; Horne, A; Arico, M; Egeler, RM; Filipovich, AH; Gadner, H; Imashuku, S; Ladisch, S; Webb, D; Janka, G; Henter, JI,期刊：Blood, 页码：4577-4584 , 文章类型： Article，,卷期：2011年118-17] Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The treatment includes immunosuppressive a... Treating limited-stage nodular lymphocyte predominant Hodgkin lymphoma similarly to classical Hodgkin lymphoma with ABVD may improve outcome [作者：Savage, KJ; Skinnider, B; Al-Mansour, M; Sehn, LH; Gascoyne, RD; Connors, JM,期刊：Blood, 页码：4585-4590 , 文章类型： Article，,卷期：2011年118-17] The appropriate therapy for limited-stage nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is unclear. In contrast to classical Hodgkin lymphoma (CHL), chemotherapy is often omitted; however, it is unknown whether... Twenty-one cases of blastic plasmacytoid dendritic cell neoplasm: focus on biallelic locus 9p21.3 deletion [作者：Lucioni, M; Novara, F; Fiandrino, G; Riboni, R; Fanoni, D; Arra, M; Venegoni, L; Nicola, M; Dallera, E; Arcaini, L; Onida, F; Vezzoli, P; Travaglino, E; Boveri, E; Zuffardi, O; Paulli, M; Berti, E,期刊：Blood, 页码：4591-4594 , 文章类型： Article，,卷期：2011年118-17] Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy derived from precursors of plasmacytoid dendritic cells. We analyzed 21 cases with array-based comparative genomic hybridization (a... Predictors of greater than 80% 2-year mortality in primary myelofibrosis: a Mayo Clinic study of 884 karyotypically annotated patients [作者：Tefferi, A; Jimma, T; Gangat, N; Vaidya, R; Begna, KH; Hanson, CA; Van Dyke, DL; Caramazza, D; Pardanani, A,期刊：Blood, 页码：4595-4598 , 文章类型： Article，,卷期：2011年118-17] DIPSS-plus (the Dynamic International Prognostic Scoring System-plus) includes 8 risk factors for survival in primary myelofibrosis. In the present study of 884 karyotypically annotated patients with primary myelofibrosi... Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease [作者：Zou, JZ; Mali, P; Huang, XS; Dowey, SN; Cheng, LZ,期刊：Blood, 页码：4599-4608 , 文章类型： Article，,卷期：2011年118-17] Human induced pluripotent stem cells (iPSCs) bearing monogenic mutations have great potential for modeling disease phenotypes, screening candidate drugs, and cell replacement therapy provided the underlying disease-causi... JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow [作者：Arcangeli, ML; Frontera, V; Bardin, F; Obrados, E; Adams, S; Chabannon, C; Schiff, C; Mancini, SJC; Adams, RH; Aurrand-Lions, M,期刊：Blood, 页码：4609-4619 , 文章类型： Article，,卷期：2011年118-17] In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Alth... Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome [作者：Jessen, B; Maul-Pavicic, A; Ufheil, H; Vraetz, T; Enders, A; Lehmberg, K; Langler, A; Gross-Wieltsch, U; Bay, A; Kaya, Z; Bryceson, YT; Koscielniak, E; Badawy, S; Davies, G; Hufnagel, M; Schmitt-Graeff, A; Aichele, P; zur Stadt, U; Schwarz, K; Ehl, S,期刊：Blood, 页码：4620-4629 , 文章类型： Article，,卷期：2011年118-17] Perforin-mediated cytotoxicity is important for controlling viral infections, but also for limiting immune reactions. Failure of this cytotoxic pathway leads to hemophagocytic lymphohistiocytosis (HLH), a life-threatenin... A novel pro-lymphangiogenic function for Th17/IL-17 [作者：Chauhan, SK; Jin, YP; Goyal, S; Lee, HS; Fuchsluger, TA; Lee, HK; Dana, R,期刊：Blood, 页码：4630-4634 , 文章类型： Article，,卷期：2011年118-17] Th17 cells, in addition to their proinflammatory functions, have been recognized as potent inducers of angiogenesis in autoimmune diseases and malignancies. In the present study, we demonstrate distinct mechanisms by whi...