- Tumor-targeted gene therapy using Adv-AFP-HRPC/IAA prodrug system suppresses growth of hepatoma xenografted in mice
[作者:Dai, M; Liu, J; Chen, DE; Rao, Y; Tang, ZJ; Ho, WZ; Dong, CY,期刊:Cancer gene therapy, 页码:77-83 , 文章类型: Article,,卷期:2012年19-2]
- Clinical efficacy of current therapies for hepatocellular carcinoma (HCC) treatment is limited. Indole-3-acetic acid (IAA) is non-toxic for mammalian cells. Oxidative decarboxylation of IAA by horseradish peroxidase (HRP...
- VSV-MP gene therapy strategy inhibits tumor growth in nude mice model of human lung adenocarcinoma
[作者:Jing, XM; Wen, YJ; Shi, W; Tang, QQ; Li, J; Chen, XC,期刊:Cancer gene therapy, 页码:101-109 , 文章类型: Article,,卷期:2012年19-2]
- Vesicular stomatitis virus (VSV) matrix protein (MP) can induce in vitro apoptosis of tumor cells in the absence of other viral components. Here, the antitumor activity of VSV-MP against lung adenocarcinoma was investiga...
- Mc-hES, a novel plasmid carrying human endostatin gene, inhibits nasopharyngeal carcinoma growth
[作者:Xu, BL; Yuan, L; Wu, JX; Xu, N; Fang, WJ; Zhao, P; Huang, WL,期刊:Cancer gene therapy, 页码:110-117 , 文章类型: Article,,卷期:2012年19-2]
- Conventional plasmids for gene therapy produce low-level and short-term gene expression. Here, we first created minicircle carrying endostatin (mc-hES) for measurement of transfection efficiency. Compared with pcDNA-hES,...
- Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells
[作者:Iguchi, K; Sakurai, F; Tomita, K; Katayama, K; Yamaguchi, T; Kawabata, K; Tagawa, M; Kawabata, M; Shirakawa, T; Mizuguchi, H,期刊:Cancer gene therapy, 页码:118-125 , 文章类型: Article,,卷期:2012年19-2]
- Carrier cells delivering a conditionally replicating adenovirus (CRAd), which selectively replicates in tumor cells and induces tumor cell lysis, have promising potential for treatment of cancer because CRAd-loaded carri...
- Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development
[作者:Lavilla-Alonso, S; Bauer, MMT; Abo-Ramadan, U; Ristimaki, A; Halavaara, J; Desmond, RA; Wang, D; Escutenaire, S; Ahtiainen, L; Saksela, K; Tatlisumak, T; Hemminki, A; Pesonen, S,期刊:Cancer gene therapy, 页码:126-134 , 文章类型: Article,,卷期:2012年19-2]
- Oncolytic adenoviruses are a promising treatment alternative for many advanced cancers, including colorectal cancer. However, clinical trials have demonstrated that single-agent therapy in advanced tumor masses is rarely...
- The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12
[作者:Reay, J; Gambotto, A; Robbins, PD,期刊:Cancer gene therapy, 页码:135-143 , 文章类型: Article,,卷期:2012年19-2]
- Interleukin (IL)-23 is a member of the IL-12 family of heterodimeric cytokines, comprised of p19 and p40 subunits, which exhibits immunostimulatory properties similar to IL-12. We have demonstrated previously that adenov...
- E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma
[作者:Adhim, Z; Lin, X; Huang, W; Morishita, N; Nakamura, T; Yasui, H; Otsuki, N; Shigemura, K; Fujisawa, M; Nibu, K; Shirakawa, T,期刊:Cancer gene therapy, 页码:144-152 , 文章类型: Article,,卷期:2012年19-2]
- Most cancer chemotherapeutic agents are administered at the maximum-tolerated dose (MTD) in short cycles with treatment breaks. However, MTD-based chemotherapies are often associated with significant toxicity and treatme...
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