- Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
[作者：WANG ADRIENNE M; MIYATA YOSHINARI; KLINEDINST SUSAN; PENG HWEIMING; CHUA JASON P; KOMIYAMA TOMOKO; LI XIAOKAI; MORISHIMA YOSHIHIRO; MERRY DIANE E; PRATT WILLIAM B; OSAWA YOICHI; COLLINS CATHERINE A; GESTWICKI JASON E; LIEBERMAN ANDREW P,期刊：NATURE CHEMICAL BIOLOGY, 页码：112-118 , 文章类型： Article，,卷期：2013年9-2]
- We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation neurodegenerative disorder. Proteostasis ...
- Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
[作者：THEOFILOPOULOS SPYRIDON; WANG YUQIN; KITAMBI SATISH SRINIVAS; SACCHETTI PAOLA; SOUSA KYLE M; BODIN KARL; KIRK JAYNE; SALTO CARMEN; GUSTAFSSON MAGNUS; TOLEDO ENRIQUE M; KARU KERSTI; GUSTAFSSON JANAKE; STEFFENSEN KNUT R; ERNFORS PATRIK; SJOVALL JAN; GRIFFITHS WILLIAM J; ARENAS ERNEST,期刊：NATURE CHEMICAL BIOLOGY, 页码：126-133 , 文章类型： Article，,卷期：2013年9-2]
- Liver X receptors (Lxr alpha and Lxr beta) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified. Here we used LC...
- Metabolite damage and its repair or pre-emption
[作者：LINSTER CAROLE L; VAN SCHAFTINGEN EMILE; HANSON ANDREW D,期刊：NATURE CHEMICAL BIOLOGY, 页码：72-80 , 文章类型： Review，,卷期：2013年9-2]
- It is increasingly evident that metabolites suffer various kinds of damage, that such damage happens in all organisms and that cells have dedicated systems for damage repair and containment. First, chemical biology is de...
- Small-molecule activation of the TRAIL receptor DR5 in human cancer cells
[作者：WANG GELIN; WANG XIAOMING; YU HONG; WEI SHUGUANG; WILLIAMS NOELLE; HOLMES DANIEL L; HALFMANN RANDAL; NAIDOO JACINTH; WANG LAI; LI LIN; CHEN SHE; HARRAN PATRICK; LEI XIAOGUANG; WANG XIAODONG,期刊：NATURE CHEMICAL BIOLOGY, 页码：84-89 , 文章类型： Article，,卷期：2013年9-2]
- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) activates apoptosis through the death receptors DR4 and DR5. Because of its superior safety profile and high tumor specificity compared to other TNF f...
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