- Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry
[作者:Shuhendler, AJ; Staruch, R; Oakden, W; Gordijo, CR; Rauth, AM; Stanisz, GJ; Chopra, R; Wu, XY,期刊:Journal of controlled release, 页码:478-484 , 文章类型: Article,,卷期:2012年157-3]
- For effective and safe thermotherapy, real-time, accurate, three-dimensional tissue thermometry is required. Magnetic resonance imaging (MRI)-based thermometry in combination with current temperature responsive contrast ...
- Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1
[作者:Bhowmick, T; Berk, E; Cui, XM; Muzykantov, VR; Muro, S,期刊:Journal of controlled release, 页码:485-492 , 文章类型: Article,,卷期:2012年157-3]
- Delivery of drugs into the endothelium by nanocarriers targeted to endothelial determinants may improve treatment of vascular maladies. This is the case for intercellular adhesion molecule 1 (ICAM-1), a glycoprotein over...
- Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues
[作者:Kim, JH; Bae, SM; Na, MH; Shin, H; Yang, YJ; Min, KH; Choi, KY; Kim, K; Park, RW; Kwon, IC; Lee, BH; Hoffman, AS; Kim, IS,期刊:Journal of controlled release, 页码:493-499 , 文章类型: Article,,卷期:2012年157-3]
- Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic ...
- Tuning core vs. shell dimensions to adjust the performance of nanoscopic containers for the loading and release of doxorubicin (vol 152, pg 37, 2011)
[作者:Lin, LY; Lee, NS; Zhu, JH; Nystrom, AM; Pochan, DJ; Dorshow, RB; Wooley, KL,期刊:Journal of controlled release, 页码:500-500 , 文章类型: Correction,,卷期:2012年157-3]
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- Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine
[作者:Bershteyn, A; Hanson, MC; Crespo, MP; Moon, JJ; Li, AV; Suh, H; Irvine, DJ,期刊:Journal of controlled release, 页码:354-365 , 文章类型: Article,,卷期:2012年157-3]
- New subunit vaccine formulations with increased potency are of interest to improve immune responses against poorly immunogenic antigens, to avoid vaccine shortages in pandemic situations, and to promote dose-sparing of p...
- Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles
[作者:Fonge, H; Huang, H; Scollard, D; Reilly, RM; Allen, C,期刊:Journal of controlled release, 页码:366-374 , 文章类型: Article,,卷期:2012年157-3]
- The physico-chemical characteristics and composition of block copolymer micelles (BCMs) may influence the pharmacokinetics and consequently, the desired delivery characteristics. In this study the influence of formulatio...
- Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half life
[作者:Shahnaz, G; Iqbal, J; Rahmat, D; Perera, G; Laffleur, F; Rossi, D; Bernkop-Schnurch, A,期刊:Journal of controlled release, 页码:375-382 , 文章类型: Article,,卷期:2012年157-3]
- It was the aim of this study to develop a sustained parenteral peptide (DALCE) delivery system by the immobilization of DALCE to thiolated carboxymethyl dextran-cysteine (CMD-Cys) via disulfide bond formation. The result...
- Sustained in vivo release from imprinted therapeutic contact lenses
[作者:Tieppo, A; White, CJ; Paine, AC; Voyles, ML; McBride, MK; Byrne, ME,期刊:Journal of controlled release, 页码:391-397 , 文章类型: Article,,卷期:2012年157-3]
- In this paper, we demonstrate the successful in vivo extended release of a small molecular weight therapeutic, ketotifen fumarate (MW=425), from molecularly imprinted, therapeutic contact lenses. This is the first time t...
- Preparation of polymer-based multimodal imaging agent to visualize the process of bone regeneration
[作者:Liu, J; Jo, J; Kawai, Y; Aoki, I; Tanaka, C; Yamamoto, M; Tabata, Y,期刊:Journal of controlled release, 页码:398-405 , 文章类型: Article,,卷期:2012年157-3]
- The objective of this study is to design a new multimodal imaging system for the evaluation of bone regeneration process. Pamidronate (PA) of bisphosphonates with a high affinity for hydroxyapatite, was introduced to pul...
- Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo
[作者:Creusat, G; Thomann, JS; Maglott, A; Pons, B; Dontenwill, M; Guerin, E; Frisch, B; Zuber, G,期刊:Journal of controlled release, 页码:418-426 , 文章类型: Article,,卷期:2012年157-3]
- Success of synthetic interfering nucleic acids (siRNAs)-based therapy relies almost exclusively on effective, safe and preferably nanometric delivery systems which can be easily prepared, even at high concentrations. We ...
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