- 3-butyl-6-fluoro-1(3H)-isobenzofuranone (6-F-NBP), a derivative of dl-n-butylphthalide, inhibits glutamate-induced cytotoxicity in PC12 cells
[作者:Zhao, N; Ji, MX; Xu, L; Ji, BS,期刊:Drug Development Research, 页码:11-17 , 文章类型: Article,,卷期:2012年73-1]
- It is widely recognized that glutamate (Glu)-induced cytotoxicity, intracellular calcium overload and the excessive free radical production are key events in the development and progression of ischemic brain injury. dl-3...
- Parallel drug development
[作者:Wiklund, SJ,期刊:Drug Development Research, 页码:24-34 , 文章类型: Article,,卷期:2012年73-1]
- In the pharmaceutical industry, it is common practice to pursue sequentially, within a family of compounds, a number of candidate compounds for further development. This article challenges the sequential tradition, and i...
- Hetastarch reduces neuronal cell death caused by oxidative stress
[作者:Lee, KY; Koh, SH; Kim, S; Park, HH; Lee, YJ,期刊:Drug Development Research, 页码:35-42 , 文章类型: Article,,卷期:2012年73-1]
- We investigated the effect of hetastarch, used for the treatment of acute ischemic stroke, on neuronal cell damage by oxidative stress, a main pathogenic mechanism in ischemic stroke. Neuronally differentiated PC12 cells...
- Synergism between tramadol and meloxicam in the formalin test involves both opioidergic and serotonergic pathways
[作者:Isiordia-Espinoza, MA; Teran-Rosales, F; Reyes-Garcia, G; Granados-Soto, V,期刊:Drug Development Research, 页码:43-50 , 文章类型: Article,,卷期:2012年73-1]
- This study was designed to evaluate the antinociceptive interaction of the tramadolmeloxicam combination in different proportions (tramadol + meloxicam in 1:1, 1:3, and 3:1 ratios), as well as the role of nitric oxide, o...
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