- The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: A novel differentiating assay
[作者:Major, TC; Dhamija, S; Black, N; Liachenko, S; Morenko, B; Sobocinski, G; Okerberg, C; Tinholt, P; Madore, S; Kowala, MC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:723-731 , 文章类型: Article,,卷期:2008年325-3]
Among the L-type calcium channel blockers (CCBs), particularly dihydropyridines like nifedipine [1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester], a common adverse effect is vas...
- Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells
[作者:Zhuang, SG; Kinsey, GR; Yan, Y; Han, JH; Schnellmann, RG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:732-740 , 文章类型: Article,,卷期:2008年325-3]
Although tubular necrosis in acute renal failure is associated with excessive production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the mechanism of ROS-induced cell necrosis remains poorly un...
- Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents
[作者:Dong, G; Wang, L; Wang, CY; Yang, TX; Kumar, MV; Dong, Z,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:978-984 , 文章类型: Article,,卷期:2008年325-3]
Inhibitors of histone deacetylases, including suberoylanilide hydroxamic acid (SAHA) and Trichostatin A, are a new class of anticancer agents. With potent chemotherapy effects in cancers, these agents are not obviousl...
- MSFTZ, a flavanone derivative, induces human hepatoma cell apoptosis via a reactive oxygen species- and caspase-dependent mitochondrial pathway
[作者:Ying, MD; Tu, CX; Ying, HZ; Hu, YZ; He, QJ; Yang, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:758-765 , 文章类型: Article,,卷期:2008年325-3]
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver. It is unfortunate that HCCs are highly refractory to conventional chemotherapy, radiation therapy, and even immunotherapy. Thus, novel therape...
- Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor
[作者:Okamura, N; Habay, SA; Zeng, J; Chamberlin, AR; Reinscheid, RK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:893-901 , 文章类型: Article,,卷期:2008年325-3]
Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist to mice or rats. We report here the chemical synthesis...
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