- 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2-(1H)quinolinone(cilostazol), a phosphodiesterase type 3 inhibitor, reduces infarct size via activation of mitochondrial Ca2+-Activated K+ channels in rabbit hearts
[作者:Fukasawa, M; Nishida, H; Sato, T; Miyazaki, M; Nakaya, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:100-104 , 文章类型: Article,,卷期:2008年326-1]
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2-(1H)quinolinone (cilostazol), a phosphodiesterase type 3 (PDE III) inhibitor, activates cAMP-dependent protein kinase A (PKA). The cAMP/PKA pathway potentiates...
- Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: Role of endogenous prostacyclin and sensory nerves
[作者:Brzozowski, T; Konturek, PC; Chlopicki, S; Sliwowski, Z; Pawlik, M; Ptak-Belowska, A; Kwiecien, S; Drozdowicz, D; Pajdo, R; Slonimska, E; Konturek, SJ; Pawlik, WW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:105-116 , 文章类型: Article,,卷期:2008年326-1]
1-Methylnicotinamide (MNA) is one of the major derivatives of nicotinamide, which was recently shown to exhibit antithrombotic and antiinflammatory actions. However, it is not yet known whether MNA affects gastric muc...
- Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release
[作者:Pariser, JJ; Partilla, JS; Dersch, CM; Ananthan, S; Rothman, RB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:286-295 , 文章类型: Article,,卷期:2008年326-1]
Previous studies identified partial inhibitors and allosteric modulators of 5-hydroxytryptamine ([5-amino-3-(3,4-dichlorophenyl)1,2- dihydropyrido[3,4-b] pyrazin-7-yl] carbamic acid ethyl ester [SoRI-6238], 4-(2-[bis(...
- Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats
[作者:Lehto, SG; Tamir, R; Deng, H; Klionsky, L; Kuang, RZ; Le, A; Lee, D; Louis, JC; Magal, E; Manning, BH; Rubino, J; Surapaneni, S; Tamayo, N; Wang, T; Wang, J; Wang, J; Wang, WY; Youngblood, B; Zhang, MS; Zhu, D; Norman, MH; Gavva, NR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:218-229 , 文章类型: Article,,卷期:2008年326-1]
Antagonists of the vanilloid receptor TRPV1 (transient receptor potential vanilloid type 1) have been reported to produce antihyperalgesic effects in animal models of pain. These antagonists, however, also caused conc...
- Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site
[作者:Rowe, BA; Schaffhauser, H; Morales, S; Lubbers, LS; Bonnefous, C; Kamenecka, TM; McQuiston, J; Daggett, LP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:240-251 , 文章类型: Article,,卷期:2008年326-1]
Glutamate is a major neurotransmitter in the central nervous system, and abnormal glutamate neurotransmission has been implicated in many neurological disorders, including schizophrenia, Alzheimer's disease, Parkinson...
- Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus
[作者:Han, F; Shioda, N; Moriguchi, S; Yamamoto, Y; Raie, AYA; Yamaguchi, Y; Hino, M; Fukunaga, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:127-134 , 文章类型: Article,,卷期:2008年326-1]
Olfactory bulbectomy (OBX) in mice elicits impaired memory and cognitive functions. Here, we found that chronic oral administration of spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) (0.1-1 mg/kg/da...
- Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha(1)-adrenoceptor stimulation
[作者:Salameh, A; Krautblatter, S; Baessler, S; Karl, S; Gomez, DR; Dhein, S; Pfeiffer, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:315-322 , 文章类型: Article,,卷期:2008年326-1]
Syncytial behavior of cardiac tissue is mainly controlled by the expression of cardiac gap junction proteins, and of these, connexin43 (Cx43) represents the predominant connexin in the working myocardium. Because the ...
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