- Deficiency of liver sinusoidal scavenger receptors stabilin-1 and-2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors
[作者:Schledzewski, K; Geraud, C; Arnold, B; Wang, SJ; Grone, HJ; Kempf, T; Wollert, KC; Straub, BK; Schirmacher, P; Demory, A; Schonhaber, H; Gratchev, A; Dietz, L; Thierse, HJ; Kzhyshkowska, J; Goerdt, S,期刊:Journal of clinical investigation, 页码:703-714 , 文章类型: Article,,卷期:2011年121-2]
- Tissue homeostasis and remodeling are processes that involve high turnover of biological macromolecules. Many of the waste molecules that are by-products or degradation intermediates of biological macromolecule turnover ...
- alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
[作者:Hansen, C; Angot, E; Bergstrom, AL; Steiner, JA; Pieri, L; Paul, G; Outeiro, TF; Melki, R; Kallunki, P; Fog, K; Li, JY; Brundin, P,期刊:Journal of clinical investigation, 页码:715-725 , 文章类型: Article,,卷期:2011年121-2]
- Post-mortem analyses of brains from patients with Parkinson disease who received fetal mesencephalic transplants show that alpha-synuclein-containing (alpha-syn-containing) Lewy bodies gradually appear in grafted neurons...
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
[作者:Igaz, LM; Kwong, LK; Lee, EB; Chen-Plotkin, A; Swanson, E; Unger, T; Malunda, J; Xu, Y; Winton, MJ; Trojanowski, JQ; Lee, VMY,期刊:Journal of clinical investigation, 页码:726-738 , 文章类型: Article,,卷期:2011年121-2]
- Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by cytoplasmic protein aggregates in the brain and spinal cord that include TAR-DNA binding protein 43 (TDP-43). TDP-43 i...
- Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells
[作者:Hong, BX; Song, XT; Rollins, L; Berry, L; Huang, XF; Chen, SY,期刊:Journal of clinical investigation, 页码:739-751 , 文章类型: Article,,卷期:2011年121-2]
- Both mucosal and systemic immune responses are required for preventing or containing HIV transmission and chronic infection. However, currently described vaccination approaches are largely ineffective in inducing both mu...
- KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation
[作者:Hassman, LM; Ellison, TJ; Kedes, DH,期刊:Journal of clinical investigation, 页码:752-768 , 文章类型: Article,,卷期:2011年121-2]
- Kaposi sarcoma-associated herpesvirus (KSHV; also known as HHV8) is the causative agent of two B cell tumors, multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). However, little is known about the n...
- alpha 3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues
[作者:Huang, GR; Ge, GX; Wang, DY; Gopalakrishnan, B; Butz, DH; Colman, RJ; Nagy, A; Greenspan, DS,期刊:Journal of clinical investigation, 页码:769-783 , 文章类型: Article,,卷期:2011年121-2]
- Collagen V, broadly expressed as alpha 1 (V)(2)alpha 2(V) heterotrimers that regulate collagen fibril geometry and strength, also occurs in some tissues, such as white adipose tissue (WAT), pancreatic islets, and skeleta...
- Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
[作者:Elkabets, M; Gifford, AM; Scheel, C; Nilsson, B; Reinhardt, F; Bray, MA; Carpenter, AE; Jirstrom, K; Magnusson, K; Ebert, BL; Ponten, F; Weinberg, RA; McAllister, SS,期刊:Journal of clinical investigation, 页码:784-799 , 文章类型: Article,,卷期:2011年121-2]
- Systemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), which are mobilized into the circulation and subsequently foster the growth of otherwise indo...
- Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
[作者:Liu, ZY; Turkoz, A; Jackson, EN; Corbo, JC; Engelbach, JA; Garbow, JR; Piwnica-Worms, DR; Kopan, R,期刊:Journal of clinical investigation, 页码:800-808 , 文章类型: Article,,卷期:2011年121-2]
- The role of the Notch signaling pathway in tumor development is complex, with Notch1 functioning either as an oncogene or as a tumor suppressor in a context-dependent manner. To further define the role of Notch1 in tumor...
- A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma
[作者:Ory, B; Ramsey, MR; Wilson, C; Vadysirisack, DD; Forster, N; Rocco, JW; Rothenberg, SM; Ellisen, LW,期刊:Journal of clinical investigation, 页码:809-820 , 文章类型: Article,,卷期:2011年121-2]
- The p53 tumor suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many human cancers. Therefore, a central challenge in human cancer therapy is the identification of pathway...
- Tim-3 expression on PD-1(+) HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity (vol 120, pg 4546, 2011)
[作者:McMahan, RH; Golden-Mason, L; Nishimura, MI; McMahon, BJ; Kemper, M; Allen, TM; Gretch, DR; Rosen, HR,期刊:Journal of clinical investigation, 页码:821-821 , 文章类型: Correction,,卷期:2011年121-2]
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- PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome (vol 120, pg 1812, 2011)
[作者:Ebermann, I; Phillips, JB; Liebau, MC; Koenekoop, RK; Schermer, B; Lopez, I; Schafer, E; Roux, AF; Dafinger, C; Bernd, A; Zrenner, E; Claustres, M; Blanco, B; Nurnberg, G; Nurnberg, P; Ruland, R; Westerfield, M; Benzing, T; Bolz, HJ,期刊:Journal of clinical investigation, 页码:821-821 , 文章类型: Correction,,卷期:2011年121-2]
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- Comparison of different miR-21 inhibitor chemistries in a cardiac disease model
[作者:Thum, T; Chau, N; Bhat, B; Gupta, SK; Linsley, PS; Bauersachs, J; Engelhardt, S,期刊:Journal of clinical investigation, 页码:461-462 , 文章类型: Letter,,卷期:2011年121-2]
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