- Histone/protein deacetylases and T-cell immune responses
[作者:Akimova, T; Beier, UH; Liu, YJ; Wang, LQ; Hancock, WW,期刊:Blood, 页码:2443-2451 , 文章类型: Review,,卷期:2012年119-11]
- Clinical and experimental studies show that inhibition of histone/protein deacetylases (HDAC) can have important antineoplastic effects through cytotoxic and proapoptotic mechanisms. There are also increasing data from n...
- Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology
[作者:Bouton, MC; Boulaftali, Y; Richard, B; Arocas, V; Michel, JB; Jandrot-Perrus, M,期刊:Blood, 页码:2452-2457 , 文章类型: Review,,卷期:2012年119-11]
- Serine protease inhibitors, termed serpins, are key regulators in many biologic events. Protease nexin-1 (PN-1) is a serpin that is barely detectable in plasma but found in many organs and produced by most cell types, in...
- How I treat enteropathy-associated T-cell lymphoma
[作者:Di Sabatino, A; Biagi, F; Gobbi, PG; Corazza, GR,期刊:Blood, 页码:2458-2468 , 文章类型: Article,,卷期:2012年119-11]
- Enteropathy-associated T-cell lymphoma (EATL) is a complication of celiac disease (CD). This tumor derives from the neoplastic transformation of aberrant intraepithelial T lymphocytes emerging in celiac patients unrespon...
- Unique features of primary myelofibrosis in Chinese
[作者:Xu, ZF; Gale, RP; Zhang, Y; Qin, TJ; Chen, HS; Zhang, PH; Zhang, TJ; Liu, L; Qu, SQ; Xiao, ZJ,期刊:Blood, 页码:2469-2473 , 文章类型: Article,,卷期:2012年119-11]
- Clinical and laboratory features of 642 consecutive Chinese subjects with primary myelofibrosis (PMF) were analyzed and compared with those of 1054 predominately white subjects with PMF. Chinese subjects were significant...
- Trastuzumab for treatment of refractory/relapsed HER2-positive adult B-ALL: results of a phase 2 GRAALL study
[作者:Chevallier, P; Robillard, N; Charbonnier, A; Raffoux, E; Maury, S; Carras, S; Chabrot, C; Fohrer, C; Bernard, M; Blade, JS; Etienne, A; Talmant, P; Delaunay, J; Guillaume, T; Mohty, M; Bene, MC; Ifrah, N; Dombret, H,期刊:Blood, 页码:2474-2477 , 文章类型: Article,,卷期:2012年119-11]
- The aim of this phase 2 study was to evaluate the efficacy and safety of trastuzumab, a humanized monoclonal antibody targeted against the human epidermal growth factor receptor 2 (HER2), for adult patients with relapsed...
- S1P promotes murine progenitor cell egress and mobilization via S1P(1)-mediated ROS signaling and SDF-1 release
[作者:Golan, K; Vagima, Y; Ludin, A; Itkin, T; Cohen-Gur, S; Kalinkovich, A; Kollet, O; Kim, C; Schajnovitz, A; Ovadya, Y; Lapid, K; Shivtiel, S; Morris, AJ; Ratajczak, MZ; Lapidot, T,期刊:Blood, 页码:2478-2488 , 文章类型: Article,,卷期:2012年119-11]
- The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as di...
- Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells
[作者:Calvi, LM; Bromberg, O; Rhee, Y; Weber, JM; Smith, JNP; Basil, MJ; Frisch, BJ; Bellido, T,期刊:Blood, 页码:2489-2499 , 文章类型: Article,,卷期:2012年119-11]
- Microenvironmental expansion of hematopoietic stem cells (HSCs) is induced by treatment with parathyroid hormone (PTH) or activation of the PTH receptor (PTH1R) in osteoblastic cells; however, the osteoblastic subset med...
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