- Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome - Ex vivo and in vivo regulation of omentin-1 by insulin and glucose
[作者：Tan, BK; Adya, R; Farhatullah, S; Lewandowski, KC; O'Hare, P; Lehnert, H; Randeva, HS,期刊：Diabetes, 页码：801-808 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Polycystic ovary syndrome (PCOS) is associated with insulin resistance and obesity. Recent studies have shown that plasma omentin-1 levels decrease with obesity. Currently, no data exist on the relative expre...
- Homocysteine upregulates resistin production from adipocytes in vivo and in vitro
[作者：Li, Y; Jiang, CT; Xu, GH; Wang, NP; Zhu, Y; Tang, CS; Wang, X,期刊：Diabetes, 页码：817-827 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Homocysteine (Hcy) is epidemiologically related to insulin resistance, which has been speculated to be a low-grade systemic inflammatory condition. Resistin acts as a critical mediator of insulin resistance a...
- Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
[作者：Chiu, JD; Richey, JM; Harrison, LN; Zuniga, E; Kolka, CM; Kirkman, E; Ellmerer, M; Bergman, RN,期刊：Diabetes, 页码：828-835 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Intravenous insulin infusion rapidly increases plasma insulin, yet glucose disposal occurs at a much slower rate. This delay in insulin's action may be related to the protracted time for insulin to traverse t...
- PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases - The Boston Puerto Rican Health Study
[作者：Lai, CQ; Tucker, KL; Parnell, LD; Adiconis, M; Garcia-Bailo, B; Griffith, J; Meydani, M; Ordovas, JM,期刊：Diabetes, 页码：809-816 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Individuals with type 2 diabetes exhibit higher DNA damage and increased risk of cardiovascular disease (CVD). However, mechanisms underlying the association between DNA damage and development of type 2 diabe...
- Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes
[作者：Pfleger, C; Mortensen, HB; Hansen, L; Herder, C; Roep, BO; Hoey, H; Aanstoot, HJ; Kocova, M; Schloot, NC,期刊：Diabetes, 页码：929-937 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - We investigated the association of anti-inflammatory cytokine interleukin (IL)-1 receptor antagonist (IL-1ra), adiponectin, proinflammatory cytokines IL-1 beta, IL-6, and CCL2, and tumor necrosis factor-a wit...
- Thioredoxin-interacting protein - A critical link between glucose toxicity and beta-cell apoptosis
[作者：Chen, J; Saxena, G; Mungrue, IN; Lusis, AJ; Shalev, A,期刊：Diabetes, 页码：938-944 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - In diabetes, glucose toxicity affects different organ systems, including pancreatic islets where it leads to beta-cell apoptosis, but the mechanisms are not fully understood. Recently, we identified thioredox...
- mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
[作者：Fraenkel, M; Ketzinel-Gilad, M; Ariav, Y; Pappo, O; Karaca, M; Castel, J; Berthault, MF; Magnan, C; Cerasi, E; Kaiser, N; Leibowitz, G,期刊：Diabetes, 页码：945-957 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Mammalian target of rapamycin (mTOR) and its downstream target S6 kinase 1 (S6K1) mediate nutrient-induced insulin resistance by downregulating insulin receptor substrate proteins with subsequent reduced Akt ...
- Regulated beta-cell regeneration in the adult mouse pancreas
[作者：Cano, DA; Rulifson, IC; Heiser, PW; Swigart, LB; Pelengaris, S; German, M; Evan, GI; Bluestone, JA; Hebrok, M,期刊：Diabetes, 页码：958-966 , 文章类型： Article，,卷期：2008年57-4]
- Several studies have shown that the adult pancreas possesses a limited potential for beta-cell regeneration upon tissue injury. One of the difficulties in studying P-cell regeneration has been the lack of a robust, synch...
- Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy
[作者：Toth, C; Rong, LL; Yang, C; Martinez, J; Song, F; Ramji, N; Brussee, V; Liu, W; Durand, J; Nguyen, MD; Schmidt, AM; Zochodne, DW,期刊：Diabetes, 页码：1002-1017 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE - Heightened expression of the receptor for advanced glycation end products (RAGE) contributes to development of systemic diabetic complications, but its contribution to diabetic neuropathy is uncertain. We stu...
- ACE2 deficiency modifies renoprotection afforded by AGE inhibition in experimental diabetes
[作者：Tikellis, C; Bialkowski, K; Pete, J; Sheehy, K; Su, Q; Johnston, C; Cooper, ME; Thomas, MC,期刊：Diabetes, 页码：1018-1025 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-The degradation of angiotensin (Ang) II by ACE2, leading to the formation of Ang 1-7, is an important step in the renin-angiotensin system (RAS) and one that is significantly altered in the diabetic kidney. Thi...
- Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas
[作者：Zhang, XY; Bao, SS; Lai, DN; Rapkins, RW; Gillies, MC,期刊：Diabetes, 页码：1026-1033 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-To elucidate the mechanism of the unique beneficial effect of intravitreal steroid therapy on diabetic macular edema, we investigated the effect of locally administered triamcinolone acetonide (TA) on the expre...
- A polymorphism in the zinc transporter gene SLC3OA8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients
[作者：Kang, ES; Kim, MS; Kim, YS; Kim, CH; Han, SJ; Chun, SW; Hur, KY; Nam, CM; Ahn, CW; Cha, BS; Kim, SI; Lee, HC,期刊：Diabetes, 页码：1043-1047 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs1326...
- Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
[作者：Black, MH; Fingerlin, TE; Allayee, H; Zhang, W; Xiang, AH; Trigo, E; Hartiala, J; Lehtinen, AB; Haffner, SM; Bergman, RN; McEachin, RC; Kjos, SL; Lawrence, JM; Buchanan, TA; Watanabe, RM,期刊：Diabetes, 页码：1048-1056 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-We hypothesized that interaction between PPARG2 Pro 12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes-related quantitative traits in Mexican-American families of a proband w...
- Association of the distal region of the ectonucteotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
[作者：Keene, KL; Mychaleckyj, JC; Smith, SG; Leak, TS; Perlegas, PS; Langefeld, CD; Freedman, BI; Rich, SS; Bowden, DW; Sale, MM,期刊：Diabetes, 页码：1057-1062 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-Variants in the ectonucleotide pyrophosphatase/ phosphodiesterase 1 (ENPP1) gene have shown positive associations with diabetes and related phenotypes, including insulin resistance, metabolic syndrome, and type...
- Insulin mutation screening in 1,044 patients with diabetes: Mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood
[作者：Edghill, EL; Flanagan, SE; Patch, AM; Boustred, C; Parrish, A; Shields, B; Shepherd, MH; Hussain, K; Kapoor, RR; Malecki, M; MacDonald, MJ; Stoy, J; Steiner, DF; Philipson, LH; Bell, GI; Hattersley, AT; Ellard, S,期刊：Diabetes, 页码：1034-1042 , 文章类型： Article，,卷期：2008年57-4]
- OBJECTIVE-Insulin gene (INS) mutations have recently been described as a cause of permanent neonatal diabetes (PND). We aimed to determine the prevalence, genetics, and clinical phenotype of INS mutations in large cohort...
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