- A Practical and Efficient Total Synthesis of Potent Insulinotropic (2S,3R,4S)-4-Hydroxyisoleucine through a Chiral N-Protected gamma-Keto-alpha-aminoester
[作者:MARIN SANDRA DE LAMO; CATALA CEDRIC; KUMAR SREEKANTHA RATNA; VALLEIX ALAIN; WAGNER ALAIN; MIOSKOWSKI CHARLES,期刊:European Journal of Organic Chemistry, 页码:3985-3989 , 文章类型: Article,,卷期:2010年-21]
- (2S,3R,4S)-4-Hydroxyisoleucine, which exhibits remarkable insulinotropic activity, is expected to be a potent drug to treat type II diabetes. We propose herein a four-step synthesis of the enantiopure natural product on ...
- 1,2-Oxazines as Building Blocks for Stereoselective Synthesis: Preparation of Oxygen-Substituted 1,2-Oxazines, either by Alcohol Addition or by Epoxidation, and Subsequent Hydrogenation Leading to 1,2-Amino Alcohols and Pyrrolidines
[作者:ZIMMER REINHOLD; BUCHHOLZ MONIKA; COLLAS MARKUS; ANGERMANN JOERG; HOMANN KAI; REISSIG HANSULRICH,期刊:European Journal of Organic Chemistry, 页码:4111-4121 , 文章类型: Article,,卷期:2010年-21]
- Stereodefined oxygen-substituted 1,2-oxazines were prepared by three different routes. The cycloaddition of enol ethers such as 1 with alpha-nitrosoalkenes generated in situ gave the heterocycles 3 and 4. Acid-catalysed ...
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