Genetic disorders such as cystic fibrosis (CF) and Duchenne muscular dystrophy (DMD) can be caused by nonsense mutations, or single point mutations that yield a premature stop codon and result in a truncated, often ma...

Casopitant mesilate is a novel, orally active tachykinin NK1 receptor antagonist. In preclinical pharmacological testing it revealed potent and long-lasting antiemetic effects both alone and in combination with ondans...

Diabetes is a growing epidemic for which new treatments are needed as it is often not controlled with current therapies. One potential means of treating diabetes is via modulation of glucose uptake. A novel strategy f...

Glucocorticoid hormones produce a diverse array of immunological and metabolic effects. Their antiinflammatory properties are commonly utilized in the treatment of inflammatory diseases and cancer, but they often caus...

Epidemiological evidence indicates that diabetes is a potential predisposing factor for neuropsychiatric deficits such as brain aging, stroke, cerebrovascular diseases, depression, anxiety and diabetic encephalopathy....

Schizophrenia is a debilitating syndrome consisting of several symptom dimensions (positive and negative symptoms; cognitive and mood disturbances) with a large unmet treatment need. Until now, the primary focus has b...

Sjogren's syndrome (SS) is a systemic autoimmune disease that presents with sicca symptomatology of the main mucosal surfaces. The main sicca features (xerophthalmia and xerostomia) are determined by specific ocular (...

Osteoporosis is the most common type of metabolic bone disease. It is characterized by low bone mass and deterioration of bone microarchitecture that leads to bone fragility and increased susceptibility to fractures. ...

The 11th International Conference on Alzheimer's Disease and Related Disorders (ICAD) 2008, held in Chicago on July 26-31, gathered nearly 5,400 neurologists and neuroscientists from over 70 countries around the world...