Antiapoptotic Bcl-2 family proteins are overexpressed in many types of tumors and are believed to be associated with tumor formation, tumor growth and drug resistance. ABT-263 is a small-molecule inhibitor of Bcl-2 pr...

AVE-0010 (ZP-10) is a glucagon-like peptide 1 (GLP-1) receptor agonist and an insulin secretagogue. In preclinical studies, AVE-0010 improved glucose tolerance, decreased water intake and produced a dose-dependent dec...

Treatment options for ovarian cancer are limited, as women diagnosed with advanced-stage disease experience disease recurrence; therefore, alternative treatment options are needed. The folate receptor alpha (FR-alpha)...

Idronoxil (phenoxodiol) is being developed as a novel anticancer therapeutic both as a single agent and as a chemosensitizer in late-stage cancers resistant or refractory to other approved chemotherapies. Idronoxil ta...

The challenge of developing an acquired immune deficiency syndrome (AIDS) vaccine continues to be paramount as the global AIDS epidemic progresses. Traditional vaccine strategies that induce broadly neutralizing antib...

Understanding the behavioral effects of herbal extracts presents a number of challenges to behavioral pharmacology. This review briefly summarizes these issues using guarana (Paullinia cupana) as an example to illustr...

Smallpox, once the scourge of mankind, has been eradicated through a coordinated vaccination campaign orchestrated by the World Health Organization (WHO). Despite this success, members of the Orthopoxvirus genus, incl...

Guillain-Barre syndrome is an immune-mediated disorder of the peripheral nervous system that manifests as a demyelinating polyneuropathy and represents one of the most common causes of acute paralysis. The causes of G...

As one of the key mediators of cerebral water transport, aquaporin-4 (AQP4) has been widely considered a potential target for drug discovery. Many studies have shown a relationship between this protein and several dis...

The fifth joint meeting of the Japanese Society for Investigative Dermatology (JSID), the Society for Investigative Dermatology (SID) and the European Society for Dermatological Research (ESDR) was held this year in K...