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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   The Pathoetiology of Neurofibromatosis 1 [作者：Jouhilahti, EM; Peltonen, S; Heape, AM; Peltonen, J,期刊：American Journal of Pathology, 页码：1932-1939 , 文章类型： Review，,卷期：2011年178-5] Although a mutation in the NF1 gene is the only factor required to initiate the neurocutaneous-skeletal neurofibromatosis 1 (NF1) syndrome, the pathoetiology of the multiple manifestations of this disease in different or... Importance of Molecular Features of Non-Small Cell Lung Cancer for Choice of Treatment [作者：Moran, C,期刊：American Journal of Pathology, 页码：1940-1948 , 文章类型： Review，,卷期：2011年178-5] Lung cancer is the leading cause of cancer-related deaths in the United States. Approximately 85% of lung cancer is categorized as non-small cell lung cancer, and traditionally, non-small cell lung cancer has been treate... Mitochondrial Biogenesis Drives Tumor Cell Proliferation [作者：Martinez-Outschoorn, UE; Pavlides, S; Sotgia, F; Lisanti, MP,期刊：American Journal of Pathology, 页码：1949-1952 , 文章类型： Editorial Material，,卷期：2011年178-5] Arsenic induces skin cancer and also lung, liver, kidney, prostate, and bladder cancer.(4) Arsenic can dissociate from soil or rocks, and arsenic contamination of the aquifer water supply is a global public health crisis... Recently Infiltrating MAC387(+) Monocytes/Macrophages A Third Macrophage Population Involved in SIV and HIV Encephalitic Lesion Formation [作者：Soulas, C; Conerly, C; Kim, WK; Burdo, TH; Alvarez, X; Lackner, AA; Williams, KC,期刊：American Journal of Pathology, 页码：2121-2135 , 文章类型： Article，,卷期：2011年178-5] Monocytes/macrophages are critical components of HIV and SW encephalitic lesions. We used in vivo BrdU labeling and markers specific to stages of macrophage differentiation or inflammation to define macrophage heterogene... A(2A) Adenosine Receptor (A(2A)AR) as a Therapeutic Target in Diabetic Retinopathy [作者：Ibrahim, AS; El-Shishtawy, MM; Zhang, WB; Caldwell, RB; Liou, GI,期刊：American Journal of Pathology, 页码：2136-2145 , 文章类型： Article，,卷期：2011年178-5] In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. A(2A) adenosine receptor (A(2A)AR) ... The Neuropathology of Fatal Cerebral Malaria in Malawian Children [作者：Dorovini-Zis, K; Schmidt, K; Huynh, H; Fu, WJ; Whitten, RO; Milner, D; Kamiza, S; Molyneux, M; Taylor, TE,期刊：American Journal of Pathology, 页码：2146-2158 , 文章类型： Article，,卷期：2011年178-5] We examined the brains of 50 Malawian children who satisfied the clinical definition of cerebral malaria (CM) during life; 37 children had sequestration of infected red blood cells (iRBCs) and no other cause of death, an... SPLUNC1 Promotes Lung Innate Defense Against Mycoplasma pneumoniae Infection in Mice [作者：Gally, F; Di, YP; Smith, SK; Minor, MN; Liu, Y; Bratton, DL; Frasch, SC; Michels, NM; Case, SR; Chu, HW,期刊：American Journal of Pathology, 页码：2159-2167 , 文章类型： Article，,卷期：2011年178-5] Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is highly expressed in normal airways, but is dramatically decreased in allergic and cigarette smoke exposure settings. We have previously demonstrated S... Dermatan Sulfate Interacts with Dead Cells and Regulates CD5(+) B-Cell Fate Implications for a Key Role in Autoimmunity [作者：Wang, JY; Lee, J; Yan, M; Rho, JH; Roehrl, MHA,期刊：American Journal of Pathology, 页码：2168-2176 , 文章类型： Article，,卷期：2011年178-5] CD5(+) (B-1a) B cells play pivotal roles in autoimmunity through expression of autoreactive B-cell receptors and production of autoantibodies. The mechanism underlying their positive selection and expansion is currently ... Human Proteins with Affinity for Dermatan Sulfate Have the Propensity to Become Autoantigens [作者：Rho, JH; Zhang, W; Murali, M; Roehrl, MNA; Wang, JY,期刊：American Journal of Pathology, 页码：2177-2190 , 文章类型： Article，,卷期：2011年178-5] The mystery of why and how a small, seemingly disparate subset of all self molecules become functional autoantigens holds a key to understanding autoimmune diseases. Here and in a companion article in this issue, we show... Overexpression of Dominant Negative Peroxisome Proliferator-Activated Receptor-gamma (PPAR gamma) in Alveolar Type II Epithelial Cells Causes Inflammation and T-Cell Suppression in the Lung [作者：Wu, LY; Wang, GX; Qu, P; Yan, C; Du, H,期刊：American Journal of Pathology, 页码：2191-2204 , 文章类型： Article，,卷期：2011年178-5] Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is an anti-inflammatory molecule. To assess its biological function in lung alveolar epithelial cells, a CCSP-rtTA/(tetO)(7)-dnPPAR gamma bitransgenic mouse m... Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism [作者：Advani, A; Huang, QL; Thai, K; Advani, SL; White, KE; Kelly, DJ; Yuen, DA; Connelly, KA; Marsden, PA; Gilbert, RE,期刊：American Journal of Pathology, 页码：2205-2214 , 文章类型： Article，,卷期：2011年178-5] Epigenetic changes in gene expression play a role in the development of diabetic complications, including nephropathy. Histone deacetylases (HDACs) are a group of enzymes that exert epigenetic effects by altering the ace... Impaired Biomechanical Properties of Diabetic Skin Implications in Pathogenesis of Diabetic Wound Complications [作者：Bermudez, DM; Herdrich, BJ; Xu, JW; Lind, R; Beason, DP; Mitchell, ME; Soslowsky, LJ; Liechty, KW,期刊：American Journal of Pathology, 页码：2215-2223 , 文章类型： Article，,卷期：2011年178-5] Diabetic skin is known to have deficient wound healing properties, but little is known of its intrinsic biomeclhanical properties. We hypothesize that diabetic skin possesses inferior biomechanical properties at baseline... Increased Expression of Wild-Type or a Centronuclear Myopathy Mutant of Dynamin 2 in Skeletal Muscle of Adult Mice Leads to Structural Defects and Muscle Weakness [作者：Cowling, BS; Toussaint, A; Amoasii, L; Koebel, P; Ferry, A; Davignon, L; Nishino, I; Mandel, JL; Laporte, J,期刊：American Journal of Pathology, 页码：2224-2235 , 文章类型： Article，,卷期：2011年178-5] Dynamin 2 (DNM2) is a large GTPase implicated in many cellular functions, including cytoskeleton regulation and endocytosis. Although ubiquitously expressed, DNM2 was found mutated in two genetic disorders affecting diff... Transcriptional Repression of Caveolin-1 (CAV1) Gene Expression by GATA-6 in Bladder Smooth Muscle Hypertrophy in Mice and Human Beings [作者：Boopathi, E; Gomes, CM; Goldfarb, R; John, M; Srinivasan, VG; Alanzi, J; Malkowicz, SB; Kathuria, H; Zderic, SA; Wein, AJ; Chacko, S,期刊：American Journal of Pathology, 页码：2236-2251 , 文章类型： Article，,卷期：2011年178-5] Hypertrophy occurs in urinary bladder wall smooth muscle (BSM) in men with partial bladder outlet obstruction (PBOO) caused by benign prostatic hyperplasia (BPH) and in animal models of PBOO. Hypertrophied BSM from the r... Aberrant Expression of Retinoic Acid Signaling Molecules Influences Patient Survival in Astrocytic Gliomas [作者：Campos, B; Centner, FS; Bermejo, JL; Ali, R; Dorsch, K; Wan, F; Felsberg, J; Ahmadi, R; Grabe, N; Reifenberger, G; Unterberg, A; Burhenne, J; Herold-Mende, C,期刊：American Journal of Pathology, 页码：1953-1964 , 文章类型： Article，,卷期：2011年178-5] Undifferentiated cell populations may influence tumor growth in malignant glioma. We investigated potential disruptions in the retinoic acid (RA) differentiation pathway that could lead to a loss of differentiation capac... Hypermethylation of a Cluster of Kruppel-Type Zinc Finger Protein Genes on Chromosome 19q13 in Oropharyngeal Squamous Cell Carcinoma [作者：Lleras, RA; Adrien, LR; Smith, RV; Brown, B; Jivraj, N; Keller, C; Sarta, C; Schlecht, NF; Harris, TM; Childs, G; Prystowsky, MB; Belbin, TJ,期刊：American Journal of Pathology, 页码：1965-1974 , 文章类型： Article，,卷期：2011年178-5] Identification of epigenetically affected genes has become an important tool for understanding both normal and aberrant gene expression in cancer. Here we report a whole-genome analysis of DNA methylation profiles in fre...