- Fussel-15, a New Player in Wound Healing, Is Deregulated in Keloid and Localized Scleroderma
[作者：Arndt, S; Schmidt, J; Wacker, E; Karrer, S; Bosserhoff, AK,期刊：American Journal of Pathology, 页码：2622-2631 , 文章类型： Article，,卷期：2011年178-6]
- Dermal wound healing depends on highly complex interplay among various cytokines and cell types. Disruption of this process can result in impaired healing in the form of excessive scarring, as is the case in fibrotic dis...
- beta-Cell Loss and beta-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
[作者：Jurgens, CA; Toukatly, MN; Fligner, CL; Udayasankar, J; Subramanian, SL; Zraika, S; Aston-Mourney, K; Carr, DB; Westermark, P; Westermark, GT; Kahn, SE; Hull, RL,期刊：American Journal of Pathology, 页码：2632-2640 , 文章类型： Article，,卷期：2011年178-6]
- Amyloid deposition and reduced beta-cell mass are pathological hallmarks of the pancreatic islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with decreased beta-cell mass is debate...
- Apoptosis-Like Cell Death Induction and Aberrant Fibroblast Properties in Human Incisional Hernia Fascia
[作者：Diaz, R; Quiles, MT; Guillem-Marti, J; Lopez-Cano, M; Huguet, P; Ramon-y-Cajal, S; Reventos, J; Armengol, M; Arbos, MA,期刊：American Journal of Pathology, 页码：2641-2653 , 文章类型： Article，,卷期：2011年178-6]
- Incisional hernia often occurs following laparotomy and can be a source of serious problems. Although there is evidence that a biological cause may underlie its development, the mechanistic link between the local tissue ...
- TRPV1 Involvement in Inflammatory Tissue Fibrosis in Mice
[作者：Okada, Y; Reinach, PS; Shirai, K; Kitano, A; Kao, WWY; Flanders, KC; Miyajima, M; Liu, HS; Zhang, JH; Saika, S,期刊：American Journal of Pathology, 页码：2654-2664 , 文章类型： Article，,卷期：2011年178-6]
- We examined whether absence or blocking of transient receptor potential vanilloid subtype 1 (TRPV1) affects the level of inflammation and fibrosis/scarring during healing of injured tissue using an alkali burn model of c...
- Characterization of the Cysteinyl Leukotriene 2 Receptor in Novel Expression Sites of the Gastrointestinal Tract
[作者：Barajas-Espinosa, A; Ochoa-Cortes, F; Moos, MP; Ramirez, FD; Vanner, SJ; Funk, CD,期刊：American Journal of Pathology, 页码：2682-2689 , 文章类型： Article，,卷期：2011年178-6]
- Cysteinyl leukotrienes (cysLTs: LTC(4), LTD(4), and LTE(4)) are pro-inflammatory lipid molecules synthesized from arachidonic acid. They exert their actions on at least two cysLT receptors (CysLT(1)R and CysLT(2)R). Endo...
- Adiponectin Regulation of Stellate Cell Activation via PPAR gamma-Dependent and -Independent Mechanisms
[作者：Shafiei, MS; Shetty, S; Scherer, PE; Rockey, DC,期刊：American Journal of Pathology, 页码：2690-2699 , 文章类型： Article，,卷期：2011年178-6]
- In this study, we elucidated the mechanism by which adiponectin modulates hepatic stellate cell activation and fibrogenesis. Adiponectin-overexpressing trans genic mice receiving thioacetamide were resistant to fibrosis,...
- A Serrated Colorectal Cancer Pathway Predominates over the Classic WNT Pathway in Patients with Hyperplastic Polyposis Syndrome
[作者：Boparai, KS; Dekker, E; Polak, MM; Musler, AR; van Eeden, S; van Noesel, CJM,期刊：American Journal of Pathology, 页码：2700-2707 , 文章类型： Article，,卷期：2011年178-6]
- Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and is associated with an increased colorectal cancer (CRC) risk. The mixture of distinct precursor lesion typ...
- Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection
[作者：Rautou, PE; Cazals-Hatem, D; Feldmann, G; Mansouri, A; Grodet, A; Barge, S; Martinot-Peignoux, M; Duces, A; Bieche, I; Lebrec, D; Bedossa, P; Paradis, V; Marcellin, P; Valla, D; Asselah, T; Moreau, R,期刊：American Journal of Pathology, 页码：2708-2715 , 文章类型： Article，,卷期：2011年178-6]
- Autophagy is a regulated process that can be involved in the elimination of intracellular microorganisms and in antigen presentation. Some in vitro studies have shown an altered autophagic response in hepatitis C virus i...
- Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes
[作者：Graham, KL; Krishnamurthy, B; Fynch, S; Mollah, ZU; Slattery, R; Santamaria, P; Kay, TW; Thomas, HE,期刊：American Journal of Pathology, 页码：2716-2725 , 文章类型： Article，,卷期：2011年178-6]
- Cytotoxic T lymphocytes (CTLs) that cause type 1 diabetes are activated in draining lymph nodes and become concentrated as fully active CTLs in inflamed pancreatic islets. It is unclear whether CTL function is driven by ...
- Resident Tissue-Specific Mesenchymal Progenitor Cells Contribute to Fibrogenesis in Human Lung Allografts
[作者：Walker, N; Badri, L; Wettlaufer, S; Flint, A; Sajjan, U; Krebsbach, PH; Keshamouni, VG; Peters-Golden, M; Lama, VN,期刊：American Journal of Pathology, 页码：2461-2469 , 文章类型： Article，,卷期：2011年178-6]
- Fibrotic obliteration of the small airways leading to progressive airflow obstruction, termed bronchiolitis obliterans syndrome (BOS), is the major cause of poor outcomes after lung transplantation. We recently demonstra...
- Skp2 Is Necessary for Myc-Induced Keratinocyte Proliferation but Dispensable for Myc Oncogenic Activity in the Oral Epithelium
[作者：Sistrunk, C; Macias, E; Nakayama, K; Kim, Y; Rodriguez-Puebla, ML,期刊：American Journal of Pathology, 页码：2470-2477 , 文章类型： Article，,卷期：2011年178-6]
- The proto-oncogene c-Myc encodes a transcription factor that is implicated in the regulation of cellular proliferation, differentiation, and apoptosis. Myc accelerates the rate of cell proliferation, at least in part, th...
- Aberrant Overexpression of the Cell Polarity Module Scribble in Human Cancer
[作者：Vaira, V; Faversani, A; Dohi, T; Maggioni, M; Nosotti, M; Tosi, D; Altieri, DC; Bosari, S,期刊：American Journal of Pathology, 页码：2478-2483 , 文章类型： Article，,卷期：2011年178-6]
- Human Scribble (Scrib) is an evolutionary-conserved cell polarity protein, but its potential role in human cancer is controversial. Herein, we show that Scrib is nearly universally overexpressed in cultured tumor cell li...
- Severe Early-Onset Preeclampsia Is Not Associated with a Change in Placental Catechol O-Methyltransferase (COMT) Expression
[作者：Palmer, K; Saglam, B; Whitehead, C; Stock, O; Lappas, M; Tong, S,期刊：American Journal of Pathology, 页码：2484-2488 , 文章类型： Article，,卷期：2011年178-6]
- The genetic deletion of catechol O-methyltransferase (COMT) in mice produces a preeclampsia-like phenotype, with mice exhibiting hypertension, proteinuria, and histological changes, consistent with human pathological fea...
- Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension
[作者：Urakami, T; Jarvinen, TAH; Toba, M; Sawada, J; Ambalavanan, N; Mann, D; McMurtry, I; Oka, M; Ruoslahti, E; Komatsu, M,期刊：American Journal of Pathology, 页码：2489-2495 , 文章类型： Article，,卷期：2011年178-6]
- Pulmonary arterial hypertension (PAH) is a disorder of the pulmonary vasculature associated with elevated pulmonary vascular resistance. Despite recent advances in the treatment of PAH, with eight approved clinical thera...
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