- Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis
[作者:Wilhelmus, MMM; Bol, JGJM; Van Haastert, ES; Rozemuller, AJM; Bu, GJ; Drukarch, B; Hoozemans, JJM,期刊:American Journal of Pathology, 页码:2152-2156 , 文章类型: Article,,卷期:2011年179-5]
- Parkinson's disease (PD) is characterized by alpha-synuclein containing Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, alpha-syn...
- Substance P Induces CCN1 Expression via Histone Deacetylase Activity in Human Colonic Epithelial Cells
[作者:Koon, HW; Shih, DQ; Hing, TC; Chen, J; Ho, S; Zhao, DZ; Targan, SR; Pothoulakis, C,期刊:American Journal of Pathology, 页码:2315-2326 , 文章类型: Article,,卷期:2011年179-5]
- We have shown that substance P (SP) and its neurokinin-1 receptor (NK-1R) regulate intestinal angiogenesis by increasing expression of protein CYR61 (the cysteine-rich angiogenic inducer 61, or CCN1) in colonic epithelia...
- IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice
[作者:Fujimoto, H; Hirase, T; Miyazaki, Y; Hara, H; Ide-Iwata, N; Nishimoto-Hazuku, A; Saris, CJM; Yoshida, H; Node, K,期刊:American Journal of Pathology, 页码:2327-2336 , 文章类型: Article,,卷期:2011年179-5]
- Inflammation driven by immune cells and pro-inflammatory cytokines is implicated in pancreatic beta-cell injury, leading to the development of diabetes mellitus. IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr ...
- Macrophage-Mediated Dorsal Root Ganglion Damage Precedes Altered Nerve Conduction in SIV-Infected Macaques
[作者:Laast, VA; Shim, B; Johanek, LM; Dorsey, JL; Hauer, PE; Tarwater, PM; Adams, RJ; Pardo, CA; McArthur, JC; Ringkamp, M; Mankowski, JL,期刊:American Journal of Pathology, 页码:2337-2345 , 文章类型: Article,,卷期:2011年179-5]
- Peripheral neuropathy is the most common neurological complication of HIV-1 infection, affecting over one-third of infected individuals, including those treated with antiretroviral therapy. To study the pathogenesis of H...
- Opposing Roles for CXCR3 Signaling in Central Nervous System Versus Ocular Inflammation Mediated by the Astrocyte-Targeted Production of IL-12
[作者:Krauthausen, M; Ellis, SL; Zimmermann, J; Sarris, M; Wakefield, D; Heneka, MT; Campbell, IL; Muller, M,期刊:American Journal of Pathology, 页码:2346-2359 , 文章类型: Article,,卷期:2011年179-5]
- CXCR3 and its ligands are important for the trafficking of activated CD4(+) T(H)1 T cells, CD8(+) T cells, and natural killer cells during inflammation. Recent functional studies demonstrate a more diverse role of CXCR3 ...
- Inducible Costimulator (ICOS) and ICOS Ligand Signaling Has Pivotal Roles in Skin Wound Healing via Cytokine Production
[作者:Maeda, S; Fujimoto, M; Matsushita, T; Hamaguchi, Y; Takehara, K; Hasegawa, M,期刊:American Journal of Pathology, 页码:2360-2369 , 文章类型: Article,,卷期:2011年179-5]
- Skin wound healing is mediated by inflammatory cell infiltration of the wound site. Inducible costimulator (ICOS), expressed on activated T cells, and its ligand, ICOS ligand (ICOSL), expressed on antigen-presenting cell...
- Severe Gammaherpesvirus-Induced Pneumonitis and Fibrosis in Syngeneic Bone Marrow Transplant Mice Is Related to Effects of Transforming Growth Factor-beta
[作者:Coomes, SM; Farmen, S; Wilke, CA; Laouar, Y; Moore, BB,期刊:American Journal of Pathology, 页码:2382-2396 , 文章类型: Article,,卷期:2011年179-5]
- Pulmonary infections and pneumonitis occur frequently after hematopoietic stem cell transplantation. Using a syngeneic mouse model of bone marrow transplantation (BMT), we have previously demonstrated that BMT mice are m...
- Human Immunodeficiency Virus Infects Human Seminal Vesicles in Vitro and in Vivo
[作者:Deleage, C; Moreau, M; Rioux-Leclercq, N; Ruffault, A; Jegou, B; Dejucq-Rainsford, N,期刊:American Journal of Pathology, 页码:2397-2408 , 文章类型: Article,,卷期:2011年179-5]
- Semen represents the main vector of HIV dissemination worldwide, yet the origin of HIV in semen remains unclear. Viral populations distinct from those found in blood have been observed in semen, indicating local viral re...
- Pathophysiological Mechanisms of Autosomal Dominant Congenital Stromal Corneal Dystrophy C-Terminal-Truncated Decorin Results in Abnormal Matrix Assembly and Altered Expression of Small Leucine-Rich Proteoglycans
[作者:Chen, SJ; Sun, M; Meng, XM; Iozzo, RV; Kao, WWY; Birk, DE,期刊:American Journal of Pathology, 页码:2409-2419 , 文章类型: Article,,卷期:2011年179-5]
- Autosomal-dominant congenital stromal corneal dystrophy (CSCD) is a human genetic disease characterized by corneal opacities beginning shortly after birth. It is linked to a frameshift mutation in decorin, resulting in a...
- Pathological Alteration of FoxO3a Activity Promotes Idiopathic Pulmonary Fibrosis Fibroblast Proliferation on Type I Collagen Matrix
[作者:Nho, RS; Hergert, P; Kahm, J; Jessurun, J; Henke, C,期刊:American Journal of Pathology, 页码:2420-2430 , 文章类型: Article,,卷期:2011年179-5]
- Idiopathic pulmonary fibrosis (IPF) is a prevalent, progressive, and incurable fibroproliferative lung disease. The phenotype of IPF fibroblasts is characterized by their ability to elude the proliferation-suppressive pr...
- Proteoglycan 4, a Novel Immunomodulatory Factor, Regulates Parathyroid Hormone Actions on Hematopoietic Cells
[作者:Novince, CM; Koh, AJ; Michalski, MN; Marchesan, JT; Wang, JS; Jung, YH; Berry, JE; Eber, MR; Rosol, TJ; Taichman, RS; McCauley, LK,期刊:American Journal of Pathology, 页码:2431-2442 , 文章类型: Article,,卷期:2011年179-5]
- Proteoglycan 4 (PRG4), a critical protective factor in articular joints, is implicated in hematopoietic progenitor cell expansion and megakaryopoiesis. PRG4 loss-of-function mutations result in camptodactyly-arthropathy-...
- LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue
[作者:Bereziat, V; Cervera, P; Le Dour, C; Verpont, MC; Dumont, S; Vantyghem, MC; Capeau, J; Vigouroux, C,期刊:American Journal of Pathology, 页码:2443-2453 , 文章类型: Article,,卷期:2011年179-5]
- Some LMNA mutations responsible for insulin-resistant lipodystrophic syndromes are associated with peripheral subcutaneous lipoatrophy and faciocervical fat accumulation. Their pathophysiologic characteristics are unknow...
- Melanocortin 4 Receptor-Deficient Mice as a Novel Mouse Model of Nonalcoholic Steatohepatitis
[作者:Itoh, M; Suganami, T; Nakagawa, N; Tanaka, M; Yamamoto, Y; Kamei, Y; Terai, S; Sakaida, I; Ogawa, Y,期刊:American Journal of Pathology, 页码:2454-2463 , 文章类型: Article,,卷期:2011年179-5]
- Obesity may be viewed as a state of chronic low-grade inflammation that participates in the development of the metabolic syndrome. Nonalcoholic steatohepatitis (NASH) is considered a hepatic phenotype of the metabolic sy...
|