- Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer Therapy
[作者：Uddin, S; Ahmed, M; Hussain, A; Abubaker, J; Al-Sanea, N; AbdulJabbar, A; Ashari, LH; Alhomoud, S; Al-Dayel, F; Jehan, Z; Bavi, P; Siraj, AK; Al-Kuraya, KS,期刊：American Journal of Pathology, 页码：537-547 , 文章类型： Article，,卷期：2011年178-2]
- To identify genes potentially playing an important role in the progression of colorectal carcinoma (CRC), we screened global gene expression using cDNA expression array on 41 CRC tissue samples and 25 noncancerous colore...
- Phosphoproteomic Analysis of Signaling Pathways in Head and Neck Squamous Cell Carcinoma Patient Samples
[作者：Frederick, MJ; VanMeter, AJ; Gadhikar, MA; Henderson, YC; Yao, H; Pickering, CC; Williams, MD; El-Naggar, AK; Sandulache, V; Tarco, E; Myers, JN; Clayman, GL; Liotta, LA; Petricoin, EF; Calvert, VS; Fodale, V; Wang, J; Weber, RS,期刊：American Journal of Pathology, 页码：548-571 , 文章类型： Article，,卷期：2011年178-2]
- Molecular targeted therapy represents a promising new strategy for treating cancers because many small-molecule inhibitors targeting protein kinases have recently become available. Reverse-phase protein microarrays (RPPA...
- Deregulation of E2-EPF Ubiquitin Carrier Protein in Papillary Renal Cell Carcinoma
[作者：Roos, FC; Evans, AJ; Brenner, W; Wondergem, B; Klomp, J; Heir, P; Roche, O; Thomas, C; Schimmel, H; Furge, KA; Teh, BT; Thuroff, JW; Hampel, C; Ohh, M,期刊：American Journal of Pathology, 页码：853-860 , 文章类型： Article，,卷期：2011年178-2]
- Molecular pathways associated with pathogenesis of sporadic papillary renal cell carcinoma (PRCC), the second most common form of kidney cancer, are poorly understood. We analyzed primary tumor specimens from 35 PRCC pat...
- Gene Expression Patterns Related to Vascular Invasion and Aggressive Features in Endometrial Cancer
[作者：Mannelqvist, M; Stefansson, IM; Bredholt, G; Bo, TH; Oyan, AM; Jonassen, I; Kalland, KH; Salvesen, HB; Akslen, LA,期刊：American Journal of Pathology, 页码：861-871 , 文章类型： Article，,卷期：2011年178-2]
- The presence of tumor cells entering vascular channels is a prognostic marker for many cancers, including endometrial carcinoma. Vascular invasion is considered to be an early step in the metastatic process and important...
- Basigin/CD147 Promotes Renal Fibrosis after Unilateral Ureteral Obstruction
[作者：Kato, N; Kosugi, T; Sato, W; Ishimoto, T; Kojima, H; Sato, Y; Sakamoto, K; Maruyama, S; Yuzawa, Y; Matsuo, S; Kadomatsu, K,期刊：American Journal of Pathology, 页码：572-579 , 文章类型： Article，,卷期：2011年178-2]
- Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors of progression to end-stage renal disease. Basigin/CD147 is a multifunctional molecule-it induces matrix metallop...
- The IL-27 Receptor Has Biphasic Effects in Crescentic Glomerulonephritis Mediated Through Th1 Responses
[作者：Summers, SA; Phoon, RKS; Ooi, JD; Holdsworth, SR; Kitching, AR,期刊：American Journal of Pathology, 页码：580-590 , 文章类型： Article，,卷期：2011年178-2]
- Despite its initially defined role as a T-helper type 1 cell (Th1)-inducing cytokine, interleukin-27 (IL-27) has complex roles in vivo. The role of IL-27 receptor (IL-27R) was defined in experimental crescentic glomerulo...
- Suppression of Prostate Cancer Cell Rolling and Adhesion to Endothelium by 1 alpha,25-Dihydroxyvitamin D-3
[作者：Hsu, JW; Yasmin-Karim, S; King, MR; Wojciechowski, JC; Mickelsen, D; Blair, ML; Ting, HJ; Ma, WL; Lee, YF,期刊：American Journal of Pathology, 页码：872-880 , 文章类型： Article，,卷期：2011年178-2]
- Adhesion of circulating prostate cancer (PCa) cells to the microvascular endothelium is a critical step during cancer metastasis. To study PCa cell rolling and adhesion behavior, we developed a dynamic flow-based microtu...
- Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma
[作者：Jean, D; Thomas, E; Manie, E; Renier, A; de Reynies, A; Lecomte, C; Andujar, P; Fleury-Feith, J; Galateau-Salle, F; Giovannini, M; Zucman-Rossi, J; Stern, MH; Jaurand, MC,期刊：American Journal of Pathology, 页码：881-894 , 文章类型： Article，,卷期：2011年178-2]
- Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed to elucidate the mechanism of mesothelioma...
- Obliterative Airway Remodeling Molecular Evidence for Shared Pathways in Transplanted and Native Lungs
[作者：Jonigk, D; Merk, M; Hussein, K; Maegel, L; Theophile, K; Muth, M; Lehmann, U; Bockmeyer, CL; Mengel, M; Gottlieb, J; Welte, T; Haverich, A; Golpon, H; Kreipe, H; Laenger, F,期刊：American Journal of Pathology, 页码：599-608 , 文章类型： Article，,卷期：2011年178-2]
- Obliteration of the small airways is a largely unresolved challenge in pulmonary medicine. It represents either the irreversible cause of functional impairment or a morphologic disorder of limited importance in a multitu...
- Rear Polarization of the Microtubule-Organizing Center in Neointimal Smooth Muscle Cells Depends on PKC alpha, ARPC5, and RHAMM
[作者：Silverman-Gavrila, R; Silverman-Gavrila, L; Hou, G; Zhang, M; Charlton, M; Bendeck, MP,期刊：American Journal of Pathology, 页码：895-910 , 文章类型： Article，,卷期：2011年178-2]
- Directed migration of smooth muscle cells (SMCs) from the media to the intima in arteries occurs during atherosclerotic plaque formation and during restenosis after angioplasty or stent application. The polarized orienta...
- Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis
[作者：Lin, SL; Chang, FC; Schrimpf, C; Chen, YT; Wu, CF; Wu, VC; Chiang, WC; Kuhnert, F; Kuo, CJ; Chen, YM; Wu, KD; Tsai, TJ; Duffield, JS,期刊：American Journal of Pathology, 页码：911-923 , 文章类型： Article，,卷期：2011年178-2]
- Microvascular pericytes and perivascular fibroblasts have recently been identified as the source of scar-producing myofibroblasts that appear after injury of the kidney. We show that cross talk between pericytes and endo...
- IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype
[作者：von der Thusen, JH; Borensztajn, KS; Moimas, S; van Heiningen, S; Teeling, P; van Berkel, TJC; Biessen, EAL,期刊：American Journal of Pathology, 页码：924-934 , 文章类型： Article，,卷期：2011年178-2]
- Insulin-like growth factor-1 (IGF-1) signaling is important for the maintenance of plaque stability in atherosclerosis due to its effects on vascular smooth muscle cell (vSMC) phenotype. To investigate this hypothesis, w...
- Mesangial Cell lntegrin alpha v beta 8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-beta and Regulating PECAM-1
[作者：Khan, S; Lakhe-Reddy, S; McCarty, JH; Sorenson, CM; Sheibani, N; Reichardt, LF; Kim, JH; Wang, BC; Sedor, JR; Schelling, JR,期刊：American Journal of Pathology, 页码：609-620 , 文章类型： Article，,卷期：2011年178-2]
- Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin alpha v beta 8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth fa...
- A Quantitative Approach to Scar Analysis
[作者：Khorasani, H; Zheng, Z; Nguyen, C; Zara, J; Zhang, XL; Wang, JC; Ting, K; Soo, C,期刊：American Journal of Pathology, 页码：621-628 , 文章类型： Article，,卷期：2011年178-2]
- Analysis of collagen architecture is essential to wound healing research. However, to date no consistent methodologies exist for quantitatively assessing dermal collagen architecture in scars. In this study, we developed...
- Identification of a Mechanism Underlying Regulation of the Anti-Angiogenic Forkhead Transcription Factor FoxO1 in Cultured Endothelial Cells and Ischemic Muscle
[作者：Milkiewicz, M; Roudier, E; Doyle, JL; Trifonova, A; Birot, O; Haas, TL,期刊：American Journal of Pathology, 页码：935-944 , 文章类型： Article，,卷期：2011年178-2]
- Chronic limb ischemia, a complication commonly observed in conjunction with cardiovascular disease, is characterized by insufficient neovascularization despite the up-regulation of pro-angiogenic mediators. One hypothesi...
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