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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin [作者：Li, XN; Song, J; Zhang, L; LeMaire, SA; Hou, XY; Zhang, C; Coselli, JS; Chen, L; Wang, XL; Zhang, Y; Shen, YH,期刊：Diabetes, 页码：2246-2257 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may attenuate these pathogenic processes. Ac... Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients [作者：Hilbrands, R; Huurman, VAL; Gillard, P; Velthuis, JHL; De Waele, M; Mathieu, C; Kaufman, L; Pipeleers-Marichal, M; Ling, ZD; Movahedi, B; Jacobs-Tulleneers-Thevissen, D; Monbaliu, D; Ysebaert, D; Gorus, FK; Roep, BO; Pipeleers, DG; Keymeulen, B,期刊：Diabetes, 页码：2267-2276 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-The metabolic outcome of islet cell transplants in type 1 diabetic patients is variable. This retrospective analysis examines whether differences in recipient characteristics at the time of transplantation are ... Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice [作者：Pocai, A; Carrington, PE; Adams, JR; Wright, M; Eiermann, G; Zhu, L; Du, XB; Petrov, A; Lassman, ME; Jiang, GQ; Liu, F; Miller, C; Tota, LM; Zhou, GC; Zhang, XP; Sountis, MM; Santoprete, A; Capito, E; Chicchi, GG; Thornberry, N; Bianchi, E; Pessi, A; Marsh, DJ; SinhaRoy, R,期刊：Diabetes, 页码：2258-2266 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects through increased energy expenditure and decrea... Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit A Mechanism of Accelerated beta-Cell Failure in Fulminant Type 1 Diabetes [作者：Tanaka, S; Nishida, Y; Aida, K; Maruyama, T; Shimada, A; Suzuki, M; Shimura, H; Takizawa, S; Takahashi, M; Akiyama, D; Arai-Yamashita, S; Furuya, F; Kawaguchi, A; Kaneshige, M; Katoh, R; Endo, T; Kobayashi, T,期刊：Diabetes, 页码：2285-2291 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Fulminant type 1 diabetes is characterized by the rapid onset of severe hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications. Causative mechanisms for accelerated beta-cell f... Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice [作者：Parker, MJ; Xue, S; Alexander, JJ; Wasserfall, CH; Campbell-Thompson, ML; Battaglia, M; Gregori, S; Mathews, CE; Song, SH; Troutt, M; Eisenbeis, S; Williams, J; Schatz, DA; Haller, MJ; Atkinson, MA,期刊：Diabetes, 页码：2277-2284 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-The autoimmune destruction of beta-cells in type 1 diabetes results in a loss of insulin production and glucose homeostasis. As such, an immense interest exists for the development of therapies capable of atten... Mitochondrial Networking Protects beta-Cells From Nutrient-Induced Apoptosis [作者：Molina, AJA; Wikstrom, JD; Stiles, L; Las, G; Mohamed, H; Elorza, A; Walzer, G; Twig, G; Katz, S; Corkey, BE; Shirihai, OS,期刊：Diabetes, 页码：2303-2315 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Previous studies have reported that beta-cell mitochondria exist as discrete organelles that exhibit heterogeneous bioenergetic capacity. To date, networking activity, and its role in mediating beta-cell mitoch... Importance of Extranuclear Estrogen Receptor-alpha and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival [作者：Liu, SH; Le May, C; Wong, WPS; Ward, RD; Clegg, DJ; Marcelli, M; Korach, KS; Mauvais-Jarvis, F,期刊：Diabetes, 页码：2292-2302 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-We showed that 17 beta-estradiol (E-2) favors pancreatic beta-cell survival via the estrogen receptor-alpha (ER alpha) in mice. E-2 activates nuclear estrogen receptors via an estrogen response element (ERE). E... Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic beta- or alpha-Cells In Vivo [作者：Ueberberg, S; Meier, JJ; Waengler, C; Schechinger, W; Dietrich, JW; Tannapfel, A; Schmitz, I; Schirrmacher, R; Koller, M; Klein, HH; Schneider, S,期刊：Diabetes, 页码：2324-2334 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Noninvasive determination of pancreatic beta-cell mass in vivo has been hampered by the lack of suitable beta-cell-specific imaging agents. This report outlines an approach for the development of novel ligands ... Islet beta-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli [作者：Carrington, EM; McKenzie, MD; Jansen, E; Myers, M; Fynch, S; Kos, C; Strasser, A; Kay, TW; Scott, CL; Allison, J,期刊：Diabetes, 页码：2316-2323 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Bcl-xL is an antiapoptotic member of the Bcl-2 family of proteins and a potent regulator of cell death. We investigated the importance of Bcl-xL for beta-cells by deleting the Bcl-x gene specifically in beta-ce... Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells [作者：Tanaka, J; Qiang, L; Banks, AS; Welch, CL; Matsumoto, M; Kitamura, T; Ido-Kitamura, Y; DePinho, RA; Accili, D,期刊：Diabetes, 页码：2344-2354 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) ... Functional Brain Connectivity and Neurocognitive Functioning in Patients With Long-Standing Type 1 Diabetes With and Without Microvascular Complications A Magnetoencephalography Study [作者：van Duinkerken, E; Klein, M; Schoonenboom, NSM; Hoogma, RPLM; Moll, AC; Snoek, FJ; Stam, CJ; Diamant, M,期刊：Diabetes, 页码：2335-2343 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Hyperglycemia-associated microvascular disease may underlie changes in cerebral functioning and cognitive performance in patients with type 1 diabetes. Functional connectivity, an indicator of functional intera... Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy [作者：Nasu, T; Maeshima, Y; Kinomura, M; Hirokoshi-Kawahara, K; Tanabe, K; Sugiyama, H; Sonoda, H; Sato, Y; Makino, H,期刊：Diabetes, 页码：2365-2375 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-The involvement of proangiogenic factors such as vascular endothelial growth factor as well as the therapeutic efficacy of angiogenesis inhibitors in early diabetic nephropathy has been reported. Vasohibin-1 (V... Selective Inhibition of Protein Kinase C beta(2) Attenuates Inducible Nitric Oxide Synthase-Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats [作者：Nagareddy, PR; Soliman, H; Lin, GR; Rajput, PS; Kumar, U; McNeill, JH; MacLeod, KM,期刊：Diabetes, 页码：2355-2364 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Impaired cardiovascular function in diabetes is partially attributed to pathological overexpression of inducible nitric oxide synthase (iNOS) in cardiovascular tissues. We examined whether the hyperglycemia-ind... Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia [作者：Shen, E; Li, YW; Li, Y; Shan, LM; Zhu, HQ; Feng, QP; Arnold, JMO; Peng, TQ,期刊：Diabetes, 页码：2386-2395 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Hyperglycemia induces reactive oxygen species (ROS) and apoptosis in cardiomyocytes, which contributes to diabetic cardiomyopathy. The present study was to investigate the role of Rac1 in ROS production and car... Dyslipidemia-Induced Neuropathy in Mice The Role of oxLDL/LOX-1 [作者：Vincent, AM; Hayes, JM; McLean, LL; Vivekanandan-Giri, A; Pennathur, S; Feldman, EL,期刊：Diabetes, 页码：2376-2385 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Neuropathy is a frequent and severe complication of diabetes. Multiple metabolic defects in type 2 diabetic patients result in oxidative injury of dorsal root ganglia (DRG) neurons. Our previous work focused on... Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue [作者：Grunnet, LG; Nilsson, E; Ling, C; Hansen, T; Pedersen, O; Groop, L; Vaag, A; Poulsen, P,期刊：Diabetes, 页码：2402-2408 , 文章类型： Article，,卷期：2009年58-10] OBJECTIVE-Common variants in FTO (the fat mass- and obesity-associated gene) associate with obesity and type 2 diabetes. The regulation and biological function of FTO mRNA expression in target tissue is unknown. We inves...