- c-Jun NH2-Terminal Kinase Activity in Subcutaneous Adipose Tissue but Not Nuclear Factor-kappa B Activity in Peripheral Blood Mononuclear Cells Is an Independent Determinant of Insulin Resistance in Healthy Individuals
[作者:Sourris, KC; Lyons, JG; de Courten, MPJ; Dougherty, SL; Henstridge, DC; Cooper, ME; Hage, M; Dart, A; Kingwell, BA; Forbes, JM; de Courten, B,期刊:Diabetes, 页码:1259-1265 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-kappa B (NF-kappa ...
- Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo
[作者:Jiang, LH; Herzog, RI; Mason, GF; de Graaf, RA; Rothman, DL; Sherwin, RS; Behar, KL,期刊:Diabetes, 页码:1266-1274 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-The objective of this study was to characterize the changes in brain metabolism caused by antecedent recurrent, hypoglycemia tinder euglycemic and hypoglycemic conditions in a rat model and to test the hypothes...
- FoxO1 Haploinsufficiency Protects Against High-Fat Diet-Induced Insulin Resistance With Enhanced Peroxisome Proliferator-Activated Receptor gamma Activation in Adipose Tissue
[作者:Kim, JJ; Li, PP; Huntley, J; Chang, JP; Arden, KC; Olefsky, JM,期刊:Diabetes, 页码:1275-1282 , 文章类型: Proceedings Paper,,卷期:2009年58-6]
- OBJECTIVE-Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling regulating metabolism and cellular differentiation in response to changes in nutrient availability. Al...
- Genetic Deficiency of Itgb2 or ItgaL Prevents Autoimmune Diabetes Through Distinctly Different Mechanisms in NOD/LtJ Mice
[作者:Glawe, JD; Patrick, DR; Huang, M; Sharp, CD; Barlow, SC; Kevil, CG,期刊:Diabetes, 页码:1292-1301 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-Insulitis is an important pathological feature of autoimmune diabetes; however, mechanisms governing the recruitment of diabetogenic T-cells into pancreatic islets are poorly understood. Here, we determined the...
- Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
[作者:Emamaullee, JA; Davis, J; Merani, S; Toso, C; Elliott, JF; Thiesen, A; Shapiro, AMJ,期刊:Diabetes, 页码:1302-1311 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-The T helper 17 (Th17) population, a subset of CD4-positive T-cells that secrete interleukin (IL)-17, has been implicated in autoimmune diseases, including multiple sclerosis and lupus. Therapeutic agents that ...
- Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic beta-Cells Leads to Increased beta-Cell Mass and Prevention of Hyperglycemia
[作者:Hamada, S; Hara, K; Hamada, T; Yasuda, H; Moriyama, H; Nakayama, R; Nagata, M; Yokono, K,期刊:Diabetes, 页码:1321-1332 , 文章类型: Proceedings Paper,,卷期:2009年58-6]
- OBJECTIVE-Components of insulin/IGF-1 receptor-mediated signaling pathways in pancreatic beta-cells have been implicated in the development of diabetes, in part through the regulation of beta-cell mass. the protein Ras h...
- Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
[作者:Kacerovsky-Bielesz, G; Chmelik, M; Ling, C; Pokan, R; Szendroedi, J; Farukuoye, M; Kacerovsky, M; Schmid, AI; Gruber, S; Wolzt, M; Moser, E; Pacini, G; Smekal, G; Groop, L; Roden, M,期刊:Diabetes, 页码:1333-1341 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-We tested the hypothesis that short-term exercise training improves hereditary insulin resistance by stimulating ATP synthesis and investigated associations With gene polymorphisms. RESEARCH DESIGN AND METHODS-...
- Exogenous Glucose-Dependent Insulinotropic Polypeptide Worsens Postprandial Hyperglycemia in Type 2 Diabetes
[作者:Chia, CW; Carlson, OD; Kim, W; Shin, YK; Charles, CP; Kim, HS; Melvin, DL; Egan, JM,期刊:Diabetes, 页码:1342-1349 , 文章类型: Proceedings Paper,,卷期:2009年58-6]
- OBJECTIVE-Glucose-dependent insulinotropic polypeptide (GIP), unlike glucagon-like peptide (GLP)-1, lacks glucose-lowering properties in patients with type 2 diabetes. We designed this study to elucidate the underlying p...
- Increased Risk of Type 2 Diabetes in Elderly Twins
[作者:Poulsen, P; Grunnet, LG; Pilgaard, K; Storgaard, H; Alibegovic, A; Sonne, MP; Carstensen, B; Beck-Nielsen, H; Vaag, A,期刊:Diabetes, 页码:1350-1355 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-Genetic susceptibility, low birth weight (LBW), and aging are key etiological factors in the development of type 2 diabetes. LBW is common among twins. It is unknown whether twin status per se is associated wit...
- Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy
[作者:Westermann, D; Walther, T; Savvatis, K; Escher, F; Sobirey, M; Riad, A; Bader, M; Schultheiss, HP; Tschope, C,期刊:Diabetes, 页码:1373-1381 , 文章类型: Article,,卷期:2009年58-6]
- OBJECTIVE-Diabetic cardiomyopathy is associated with increased mortality in patients with diabetes. The underlying pathology of this disease is still under discussion. We studied the role of the kinin B1 receptor on the ...
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