- Nanoparticle-Mediated Expression of an Angiogenic Inhibitor Ameliorates Ischemia-Induced Retinal Neovascularization and Diabetes-Induced Retinal Vascular Leakage
[作者：Park, K; Chen, Y; Hu, Y; Mayo, AS; Kompella, UB; Longeras, R; Ma, JX,期刊：Diabetes, 页码：1902-1913 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-The aim of the study is to evaluate the effect of nanoparticle-mediated gene delivery of angiogenic inhibitors on retinal inflammation, vascular leakage, and neovascularization in diabetic retinopathy. RESEARCH...
- Adult Stature and Diabetes Complications in Patients With Type 1 Diabetes The FinnDiane Study and the Diabetes Control and Complications Trial
[作者：Waden, J; Forsblom, C; Thorn, LM; Saraheimo, M; Rosengard-Barlund, M; Heikkila, O; Hietala, K; Ong, K; Wareham, N; Groop, PH,期刊：Diabetes, 页码：1914-1920 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Short adult stature has previously been associated with cardiovascular disease, but its relationship with the microvascular complications of diabetes is uncertain. Therefore, we evaluated the association betwee...
- Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women A Randomized, Controlled Trial
[作者：Song, YQ; Cook, NR; Albert, CM; Van Denburgh, M; Manson, JE,期刊：Diabetes, 页码：1921-1928 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering...
- Identification of a Novel beta-Cell Glucokinase (GCK) Promoter Mutation (-71G > C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans
[作者：Gasperikova, D; Tribble, ND; Stanik, J; Huckova, M; Misovicova, N; van de Bunt, M; Valentinova, L; Barrow, BA; Barak, L; Dobransky, R; Bereczkova, E; Michalek, J; Wicks, K; Colclough, K; Knight, JC; Ellard, S; Klimes, I; Gloyn, AL,期刊：Diabetes, 页码：1929-1935 , 文章类型： Proceedings Paper，,卷期：2009年58-8]
- OBJECTIVE-Inactivating mutations in glucokinase (GCK) cause mild fasting hyperglycemia. Identification of a GCK mutation has implications for treatment and prognosis; therefore, it is important to identify these individu...
- Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort
[作者：Maskarinec, G; Erber, E; Grandinetti, A; Verheus, M; Oum, R; Hopping, BN; Schmidt, MM; Uchida, A; Juarez, DT; Hodges, K; Kolonel, LN,期刊：Diabetes, 页码：1732-1738 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Using the Hawaii component of the Multiethnic Cohort (MEC), we estimated diabetes incidence among Caucasians, Japanese Americans, and Native Hawaiians. RESEARCH DESIGN AND METHODS-After excluding subjects who r...
- Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
[作者：Tu, P; Bhasin, S; Hruz, PW; Herbst, KL; Castellani, LW; Hua, N; Hamilton, JA; Guo, W,期刊：Diabetes, 页码：1739-1748 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Insulin-resistant states, such as obesity and type 2 diabetes, contribute substantially to accelerated atherogenesis. Null imitations of myostatin (Mstn) are associated with increased muscle mass and decreased ...
- Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
[作者：Peter, A; Weigert, C; Staiger, H; Machicao, F; Schick, F; Machann, J; Stefan, N; Thamer, C; Haring, HU; Schleicher, E,期刊：Diabetes, 页码：1757-1765 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Increased plasma levels of free fatty acids occur in obesity and type 2 diabetes and contribute to the development of insulin resistance. Saturated fatty acids (SFAs) such as palmitate especially have lipotoxic...
- Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase
[作者：Ussher, JR; Koves, TR; Jaswal, JS; Zhang, L; Ilkayeva, O; Dyck, JRB; Muoio, DM; Lopaschuk, GD,期刊：Diabetes, 页码：1766-1775 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Whereas an impaired ability to oxidize fatty acids is thought to contribute to intracellular lipid accumulation, insulin resistance, and cardiac dysfunction, high rates of fatty acid oxidation could also impair...
- Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose
[作者：Kos, K; Wong, S; Tan, B; Gummesson, A; Jernas, M; Franck, N; Kerrigan, D; Nystrom, FH; Carlsson, LMS; Randeva, HS; Pinkney, JH; Wilding, JPH,期刊：Diabetes, 页码：1780-1788 , 文章类型： Proceedings Paper，,卷期：2009年58-8]
- OBJECTIVE-Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis. Adipose tissue collagen has recentl...
- Diabetes-Specific HLA-DR-Restricted Proinflammatory T-Cell Response to Wheat Polypeptides in Tissue Transglutaminase Antibody-Negative Patients With Type 1 Diabetes
[作者：Mojibian, M; Chakir, H; Lefebvre, DE; Crookshank, JA; Sonier, B; Keely, E; Scott, FW,期刊：Diabetes, 页码：1789-1796 , 文章类型： Proceedings Paper，,卷期：2009年58-8]
- OBJECTIVE-There is evidence of gut barrier and immune system dysfunction in some patients with type 1 diabetes, possibly linked with exposure to dietary wheat polypeptides (WP). However, questions arise regarding the fre...
- Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and-9
[作者：Ding, YC; Xu, DM; Feng, G; Bushell, A; Muschel, RJ; Wood, KJ,期刊：Diabetes, 页码：1797-1806 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified. RESEARCH DESIGN AND MET...
- Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in beta-Cells
[作者：Grunnet, LG; Aikin, R; Tonnesen, MF; Paraskevas, S; Blaabjerg, L; Storling, J; Rosenberg, L; Billestrup, N; Maysinger, D; Mandrup-Poulsen, T,期刊：Diabetes, 页码：1807-1815 , 文章类型： Proceedings Paper，,卷期：2009年58-8]
- OBJECTIVE-Proinflammatory cytokines are cytotoxic to beta-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial apoptotic pathway in ...
- Deletion of PKC epsilon Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse beta-Cells
[作者：Cantley, J; Burchfield, JG; Pearson, GL; Schmitz-Peiffer, C; Leitges, M; Biden, TJ,期刊：Diabetes, 页码：1826-1834 , 文章类型： Article，,卷期：2009年58-8]
- OBJECTIVE-Insufficient insulin secretion is a hallmark of type 2 diabetes, and exposure of beta-cells to elevated lipid levels (lipotoxicity) contributes to secretory dysfunction. Functional ablation of protein kinase C ...
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