- Encephalomyocarditis Virus 2A Protein Is Required for Viral Pathogenesis and Inhibition of Apoptosis
[作者:Carocci, M; Cordonnier, N; Huet, H; Romey, A; Relmy, A; Gorna, K; Blaise-Boisseau, S; Zientara, S; Kassimi, LB,期刊:Journal of virology, 页码:10741-10754 , 文章类型: Article,,卷期:2011年85-20]
- The encephalomyocarditis virus (EMCV), a Picornaviridae virus, has a wide host spectrum and can cause various diseases. EMCV virulence factors, however, are as yet ill defined. Here, we demonstrate that the EMCV 2A prote...
- Molecular Surveillance of HIV-1 in Madrid, Spain: a Phylogeographic Analysis
[作者:Gonzalez-Alba, JM; Holguin, A; Garcia, R; Garcia-Bujalance, S; Alonso, R; Suarez, A; Delgado, R; Cardenoso, L; Gonzalez, R; Garcia-Bermejo, I; Portero, F; de Mendoza, C; Gonzalez-Candelas, F; Galan, JC,期刊:Journal of virology, 页码:10755-10763 , 文章类型: Article,,卷期:2011年85-20]
- The molecular epidemiology of HIV-1 is constantly changing, mainly as a result of human migratory flows and the high adaptive ability of the virus. In recent years, Spain has become one of Europe's main destinations for ...
- Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93
[作者:Costenaro, L; Kaczmarska, Z; Arnan, C; Janowski, R; Coutard, B; Sola, M; Gorbalenya, AE; Norder, H; Canard, B; Coll, M,期刊:Journal of virology, 页码:10764-10773 , 文章类型: Article,,卷期:2011年85-20]
- Members of the Enterovirus genus of the Picornaviridae family are abundant, with common human pathogens that belong to the rhinovirus (HRV) and enterovirus (EV) species, including diverse echo-, coxsackie-and polioviruse...
- Novel Reassortment of Eurasian Avian-Like and Pandemic/2009 Influenza Viruses in Swine: Infectious Potential for Humans
[作者:Zhu, HC; Zhou, BP; Fan, XH; Lam, TTY; Wang, J; Chen, A; Chen, XC; Chen, HL; Webster, RG; Webby, R; Peiris, JSM; Smith, DK; Guan, Y,期刊:Journal of virology, 页码:10432-10439 , 文章类型: Article,,卷期:2011年85-20]
- Pigs are considered to be intermediate hosts and "mixing vessels," facilitating the genesis of pandemic influenza viruses, as demonstrated by the emergence of the 2009 H1N1 pandemic (pdm/09) virus. The prevalence and rep...
- Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations
[作者:Keck, ZY; Saha, A; Xia, JM; Wang, Y; Lau, P; Krey, T; Rey, FA; Foung, SKH,期刊:Journal of virology, 页码:10451-10463 , 文章类型: Article,,卷期:2011年85-20]
- Understanding the interaction between broadly neutralizing antibodies and their epitopes provides a basis for the rational design of a preventive hepatitis C virus (HCV) vaccine. CBH-2, HC-11, and HC-1 are representative...
- Engineering T Cells Specific for a Dominant Severe Acute Respiratory Syndrome Coronavirus CD8 T Cell Epitope
[作者:Oh, HLJ; Chia, A; Chang, CXL; Leong, HN; Ling, KL; Grotenbreg, GM; Gehring, AJ; Tan, YJ; Bertoletti, A,期刊:Journal of virology, 页码:10464-10471 , 文章类型: Article,,卷期:2011年85-20]
- Severe acute respiratory syndrome (SARS) is a highly contagious and life threatening disease, with a fatality rate of almost 10%. The etiologic agent is a novel coronavirus, severe acute respiratory syndrome coronavirus ...
- Immunization with a Vaccine Combining Herpes Simplex Virus 2 (HSV-2) Glycoprotein C (gC) and gD Subunits Improves the Protection of Dorsal Root Ganglia in Mice and Reduces the Frequency of Recurrent Vaginal Shedding of HSV-2 DNA in Guinea Pigs Compared to Immunization with gD Alone
[作者:Awasthi, S; Lubinski, JM; Shaw, CE; Barrett, SM; Cai, M; Wang, FS; Betts, M; Kingsley, S; DiStefano, DJ; Balliet, JW; Flynn, JA; Casimiro, DR; Bryan, JT; Friedman, HM,期刊:Journal of virology, 页码:10472-10486 , 文章类型: Article,,卷期:2011年85-20]
- Attempts to develop a vaccine to prevent genital herpes simplex virus 2 (HSV-2) disease have been only marginally successful, suggesting that novel strategies are needed. Immunization with HSV-2 glycoprotein C (gC-2) and...
- Targeting the Human Papillomavirus E6 and E7 Oncogenes through Expression of the Bovine Papillomavirus Type 1 E2 Protein Stimulates Cellular Motility
[作者:Morrison, MA; Morreale, RJ; Akunuru, S; Kofron, M; Zheng, Y; Wells, SI,期刊:Journal of virology, 页码:10487-10498 , 文章类型: Article,,卷期:2011年85-20]
- Expression of the high-risk human papillomavirus (HPV) E6 and E7 oncogenes is essential for the initiation and maintenance of cervical cancer. The repression of both was previously shown to result in activation of their ...
- Determining the Frequency and Mechanisms of HIV-1 and HIV-2 RNA Copackaging by Single-Virion Analysis
[作者:Dilley, KA; Ni, N; Nikolaitchik, OA; Chen, JB; Galli, A; Hu, WS,期刊:Journal of virology, 页码:10499-10508 , 文章类型: Article,,卷期:2011年85-20]
- HIV-1 and HIV-2 are derived from two distinct primate viruses and share only limited sequence identity. Despite this, HIV-1 and HIV-2 Gag polyproteins can coassemble into the same particle and their genomes can undergo r...
- Cross-Linking of Rotavirus Outer Capsid Protein VP7 by Antibodies or Disulfides Inhibits Viral Entry
[作者:Aoki, ST; Trask, SD; Coulson, BS; Greenberg, HB; Dormitzer, PR; Harrison, SC,期刊:Journal of virology, 页码:10509-10517 , 文章类型: Article,,卷期:2011年85-20]
- Antibodies that neutralize rotavirus infection target outer coat proteins VP4 and VP7 and inhibit viral entry. The structure of a VP7-Fab complex (S. T. Aoki, et al., Science 324: 1444-1447, 2009) led us to reclassify ep...
- Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection
[作者:Ganusov, VV; Goonetilleke, N; Liu, MKP; Ferrari, G; Shaw, GM; McMichael, AJ; Borrow, P; Korber, BT; Perelson, AS,期刊:Journal of virology, 页码:10518-10528 , 文章类型: Article,,卷期:2011年85-20]
- HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. We used single-genome amplification and sequencing of complete HIV genomes to identify longitudinal changes in t...
- A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection
[作者:Lu, L; Palaniyandi, S; Zeng, RY; Bai, Y; Liu, XD; Wang, YS; Pauza, CD; Roopenian, DC; Zhu, XP,期刊:Journal of virology, 页码:10542-10553 , 文章类型: Article,,卷期:2011年85-20]
- Strategies to prevent the sexual transmission of HIV include vaccines that elicit durable, protective mucosal immune responses. A key to effective mucosal immunity is the capacity for antigens administered locally to cro...
- Targeted Bacterial Immunity Buffers Phage Diversity
[作者:Haerter, JO; Trusina, A; Sneppen, K,期刊:Journal of virology, 页码:10554-10560 , 文章类型: Article,,卷期:2011年85-20]
- Bacteria have evolved diverse defense mechanisms that allow them to fight viral attacks. One such mechanism, the clustered, regularly interspaced, short palindromic repeat (CRISPR) system, is an adaptive immune system co...
- Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy
[作者:Su, WC; Chao, TC; Huang, YL; Weng, SC; Jeng, KS; Lai, MMC,期刊:Journal of virology, 页码:10561-10571 , 文章类型: Article,,卷期:2011年85-20]
- Autophagy has been shown to facilitate replication or production of hepatitis C virus (HCV); nevertheless, how HCV induces autophagy remains unclear. Here, we demonstrate that HCV nonstructural protein 4B (NS4B) alone ca...
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