个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   MicroRNAs as therapeutic targets for lung cancer [作者：Cho, WCS,期刊：Expert Opinion on Therapeutic Targets, 页码：1005-1008 , 文章类型： Editorial Material，,卷期：2010年14-10] Lung cancer is one of the leading causes of mortality in the world, indicating the need for innovative therapies for the disease. In recent years, microRNAs have emerged as one of the key players in regulating gene expre... Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions [作者：Bhuiyan, MS; Tagashira, H; Shioda, N; Fukunaga, K,期刊：Expert Opinion on Therapeutic Targets, 页码：1009-1022 , 文章类型： Article，,卷期：2010年14-10] Objective: We here investigated the effect of sigma-1 receptor (Sig-1R) stimulation with fluvoxamine on myocardial hypertrophy, cardiac functional recovery and defined mechanisms underlying its cardioprotective action. M... HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer [作者：Jackson, AL; Zhou, B; Kim, WY,期刊：Expert Opinion on Therapeutic Targets, 页码：1047-1057 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: The role of angiogenesis in the initiation and progression of NSCLC and the molecular alterations leading to the growth of tumor vasculature are areas of great interest and recent therapeutic suc... Periodontitis and cardiovascular diseases [作者：Suzuki, J; Aoyama, N; Ogawa, M; Hirata, Y; Izumi, Y; Nagai, R; Isobe, M,期刊：Expert Opinion on Therapeutic Targets, 页码：1023-1027 , 文章类型： Article，,卷期：2010年14-10] Periodontitis is characterized by gingival inflammation and periodontopathic bacteria generate immunological inflammatory responses. Recent epidemiological reports suggest that periodontitis is one of the key risk factor... PPARs as therapeutic targets in cardiovascular disease [作者：van Bilsen, M; van Nieuwenhoven, FA,期刊：Expert Opinion on Therapeutic Targets, 页码：1029-1045 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: The role of peroxisome proliferator-activated receptors PPAR alpha, PPAR delta and PPAR gamma in cardiovascular disease is receiving widespread attention. As ligand-activated nuclear receptors, t... Adrenomedullin as a therapeutic target in angiogenesis [作者：Deville, JL; Salas, S; Figarella-Branger, D; Ouafik, L; Daniel, L,期刊：Expert Opinion on Therapeutic Targets, 页码：1059-1072 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: Hypoxia, a frequent characteristic in the microenvironment of solid tumors, leads to adrenomedullin (AM) upregulation through the hypoxia inducible factor-1 pathway, explaining its high expressio... Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors [作者：Linger, RM; Keating, AK; Earp, HS; Graham, DK,期刊：Expert Opinion on Therapeutic Targets, 页码：1073-1090 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: Axl and/or Mer expression correlates with poor prognosis in several cancers. Until recently, the role of these receptor tyrosine kinases (RTKs) in development and progression of cancer remained u... Targeting miRNAs in osteoblast differentiation and bone formation [作者：Hu, R; Li, H; Liu, W; Yang, L; Tan, YF; Luo, XH,期刊：Expert Opinion on Therapeutic Targets, 页码：1109-1120 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: Bone tissue arises from mesenchymal stromal cells (MSCs) differentiated into the osteoblast lineage by genetic and epigenetic mechanisms. Emerging evidence indicates that the class of small non-c... Targeting Fas in osteoresorptive disorders [作者：Kovacic, N; Grcevic, D; Katavic, V; Lukic, IK; Marusic, A,期刊：Expert Opinion on Therapeutic Targets, 页码：1121-1134 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: Fas receptor is a mediator of the external apoptotic pathway in many cells and tissues. It is proposed that Fas receptor mediates osteoresorptive effects of estrogen deficiency and local/systemic... TRAIL receptor signaling and therapeutics [作者：Abdulghani, J; El-Deiry, WS,期刊：Expert Opinion on Therapeutic Targets, 页码：1091-1108 , 文章类型： Review，,卷期：2010年14-10] Importance of the field: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines, which can induce apoptotic cell death in a variety of tumor cells by engaging specific death receptors, T...