- Oct4 and LIF/Stat3 Additively Induce Kruppel Factors to Sustain Embryonic Stem Cell Self-Renewal
[作者:Hall, J; Guo, G; Wray, J; Eyres, I; Nichols, J; Grotewold, L; Morfopoulou, S; Humphreys, P; Mansfield, W; Walker, R; Tomlinson, S; Smith, A,期刊:Cell Stem Cell, 页码:597-609 , 文章类型: Article,,卷期:2009年5-6]
- Embryonic stem cell (ESC) pluripotency is dependent on an intrinsic gene regulatory network centered on Oct4. Propagation of the pluripotent state is stimulated by the cytokine leukemia inhibitory factor (LIF) acting thr...
- SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
[作者:Biernaskie, J; Paris, M; Morozova, O; Fagan, BM; Marra, M; Pevny, L; Miller, FD,期刊:Cell Stem Cell, 页码:610-623 , 文章类型: Article,,卷期:2009年5-6]
- Despite the remarkable regenerative capacity of mammalian skin, an adult dermal stem cell has not yet been identified. Here, we investigated whether skin-derived precursors (SKPs) might fulfill such a role. We show that ...
- Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease
[作者:Sun, BG; Halabisky, B; Zhou, YG; Palop, JJ; Yu, GQ; Mucke, L; Gan, L,期刊:Cell Stem Cell, 页码:624-633 , 文章类型: Article,,卷期:2009年5-6]
- Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. Howe...
- GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice
[作者:Li, G; Bien-Ly, N; Andrews-Zwilling, Y; Xu, Q; Bernardo, A; Ring, K; Halabisky, B; Deng, CH; Mahley, RW; Huang, YD,期刊:Cell Stem Cell, 页码:634-645 , 文章类型: Article,,卷期:2009年5-6]
- Apolipoprotein (apo) E, a polymorphic protein with three isoforms (apoE2, apoE3, and apoE4), is essential for lipid homeostasis. Carriers of apoE4 are at higher risk for developing Alzheimer's disease. We have investigat...
- Wnt1-Imx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway
[作者:Chung, S; Leung, A; Han, BS; Chang, MY; Moon, JI; Kim, CH; Hong, S; Pruszak, J; Isacson, O; Kim, KS,期刊:Cell Stem Cell, 页码:646-658 , 文章类型: Article,,卷期:2009年5-6]
- Selective degeneration of midbrain dopaminergic (mDA) neurons is associated with Parkinson's disease (PD), and thus an in-depth understanding of molecular pathways underlying mDA development will be crucial for optimal b...
- Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
[作者:Kranc, KR; Schepers, H; Rodrigues, NP; Bamforth, S; Villadsen, E; Ferry, H; Bouriez-Jones, T; Sigvardsson, M; Bhattacharya, S; Jacobsen, SE; Enver, T,期刊:Cell Stem Cell, 页码:659-665 , 文章类型: Article,,卷期:2009年5-6]
- The regulatory pathways necessary for the maintenance of adult hematopoietic stem cells (HSCs) remain poorly defined. By using loss-of-function approaches, we report a selective and cell-autonomous requirement for the p3...
- Separating Stem Cells by Flow Cytometry: Reducing Variability for Solid Tissues
[作者:Alexander, CM; Puchalski, J; Klos, KS; Badders, N; Ailles, L; Kim, CF; Dirks, P; Smalley, MJ,期刊:Cell Stem Cell, 页码:579-583 , 文章类型: Editorial Material,,卷期:2009年5-6]
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