- Sparing methylation of beta-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro
[作者:Salem, LB; Bosquillon, C; Dailey, LA; Delattre, L; Martin, GP; Evrard, B; Forbes, B,期刊:Journal of controlled release, 页码:110-116 , 文章类型: Article,,卷期:2009年136-2]
- Cyclodextrins (CDs) are promising solubility enhancers for inhaled drug delivery. However, they have dose-dependent effects on the respiratory epithelium, which may have advantages for permeability enhancement but also g...
- Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system
[作者:Nayak, UY; Shavi, GV; Nayak, Y; Averinen, RK; Mutalik, S; Reddy, SM; Das Gupta, P; Udupa, N,期刊:Journal of controlled release, 页码:125-131 , 文章类型: Article,,卷期:2009年136-2]
- The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovasc...
- Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery
[作者:Higashi, T; Khalil, IA; Maiti, KK; Lee, WS; Akita, H; Harashima, H; Chung, SK,期刊:Journal of controlled release, 页码:140-147 , 文章类型: Article,,卷期:2009年136-2]
- In this study, we investigated the possible use of novel lipiclated sorbitol-based transporters as functional devices for the improvement of non-viral gene delivery. These transporters are composed of a sorbitol scaffold...
- Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B
[作者:Jain, AK; Goyal, AK; Gupta, PN; Khatri, K; Mishra, N; Mehta, A; Mangal, S; Vyas, SP,期刊:Journal of controlled release, 页码:161-169 , 文章类型: Article,,卷期:2009年136-2]
- Poly lactic acid (PLA) is one of widely used biodegradable polymer in vaccine delivery. However, the use is restricted due to hydrophobic nature and generation of acidic microenvironment upon its degradation, rendering i...
- Thixotropic property in pharmaceutical formulations
[作者:Lee, CH; Moturi, V; Lee, YY,期刊:Journal of controlled release, 页码:88-98 , 文章类型: Review,,卷期:2009年136-2]
- This review focuses on the characterization of the thixotropic property, the factors affecting the thixotropic property and its pharmaceutical applications. These factors include pH, temperature, polymer concentrations, ...
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