- Defining the cellular precursors to human breast cancer
[作者:Keller, PJ; Arendt, LM; Skibinski, A; Logvinenko, T; Klebba, I; Dong, SM; Smith, AE; Prat, A; Perou, CM; Gilmore, H; Schnitt, S; Naber, SP; Garlick, JA; Kuperwasser, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2772-2777 , 文章类型: Article,,卷期:2012年109-8]
- Human breast cancers are broadly classified based on their gene-expression profiles into luminal-and basal-type tumors. These two major tumor subtypes express markers corresponding to the major differentiation states of ...
- Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
[作者:Herschkowitz, JI; Zhao, W; Zhang, M; Usary, J; Murrow, G; Edwards, D; Knezevic, J; Greene, SB; Darr, D; Troester, MA; Hilsenbeck, SG; Medina, D; Perou, CM; Rosen, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2778-2783 , 文章类型: Article,,卷期:2012年109-8]
- The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transit...
- Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
[作者:Conley, SJ; Gheordunescu, E; Kakarala, P; Newman, B; Korkaya, H; Heath, AN; Clouthier, SG; Wicha, MS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2784-2789 , 文章类型: Article,,卷期:2012年109-8]
- Antiangiogenic therapy has been thought to hold significant potential for the treatment of cancer. However, the efficacy of such treatments, especially in breast cancer patients, has been called into question, as recent ...
- MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
[作者:Miller, BH; Zeier, Z; Xi, L; Lanz, TA; Deng, SB; Strathmann, J; Willoughby, D; Kenny, PJ; Elsworth, JD; Lawrence, MS; Roth, RH; Edbauer, D; Kleiman, RJ; Wahlestedt, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3125-3130 , 文章类型: Article,,卷期:2012年109-8]
- Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are small noncoding RNA sequences critical to neurodev...
- Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression
[作者:Zhang, XL; Farrell, AS; Daniel, CJ; Arnold, H; Scanlan, C; Laraway, BJ; Janghorban, M; Lum, L; Chen, DX; Troxell, M; Sears, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2790-2795 , 文章类型: Article,,卷期:2012年109-8]
- High expression of the oncoprotein Myc has been linked to poor outcome in human tumors. Although MYC gene amplification and translocations have been observed, this can explain Myc overexpression in only a subset of human...
- Leukocyte composition of human breast cancer
[作者:Ruffell, B; Au, A; Rugo, HS; Esserman, LJ; Hwang, ES; Coussens, LM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2796-2801 , 文章类型: Article,,卷期:2012年109-8]
- Retrospective clinical studies have used immune-based biomarkers, alone or in combination, to predict survival outcomes for women with breast cancer (BC); however, the limitations inherent to immunohistochemical analyses...
- Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
[作者:Kristensen, VN; Vaske, CJ; Ursini-Siegel, J; Van Loo, P; Nordgard, SH; Sachidanandam, R; Sorlie, T; Warnberg, F; Haakensen, VD; Helland, A; Naume, B; Perou, CM; Haussler, D; Troyanskaya, OG; Borresen-Dale, AL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2802-2807 , 文章类型: Article,,卷期:2012年109-8]
- We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data in...
- Temporally-independent functional modes of spontaneous brain activity
[作者:Smith, SM; Miller, KL; Moeller, S; Xu, JQ; Auerbach, EJ; Woolrich, MW; Beckmann, CF; Jenkinson, M; Andersson, J; Glasser, MF; Van Essen, DC; Feinberg, DA; Yacoub, ES; Ugurbil, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3131-3136 , 文章类型: Article,,卷期:2012年109-8]
- Resting-state functional magnetic resonance imaging has become a powerful tool for the study of functional networks in the brain. Even "at rest," the brain's different functional networks spontaneously fluctuate in their...
- Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
[作者:Zuckerman, JE; Choi, CHJ; Han, H; Davis, ME,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3137-3142 , 文章类型: Article,,卷期:2012年109-8]
- Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a compon...
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
[作者:Wei, W; Dutchak, PA; Wang, XD; Ding, XS; Wang, XQ; Bookout, AL; Goetz, R; Mohammadi, M; Gerard, RD; Dechow, PC; Mangelsdorf, DJ; Kliewer, SA; Wan, YH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3143-3148 , 文章类型: Article,,卷期:2012年109-8]
- The endocrine hormone fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism and a promising drug for type 2 diabetes. Here we identify FGF21 as a potent regulator of skeletal homeost...
- Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2
[作者:Jiang, JX; Ganesh, T; Du, YH; Quan, Y; Serrano, G; Qui, M; Speigel, I; Rojas, A; Lelutiu, N; Dingledine, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3149-3154 , 文章类型: Article,,卷期:2012年109-8]
- With interest waning in the use of cyclooxygenase-2 (COX-2) inhibitors for inflammatory disease, prostaglandin receptors provide alternative targets for the treatment of COX-2-mediated pathological conditions in both the...
- Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
[作者:Marcotte, R; Smith, HW; Sanguin-Gendreau, V; McDonough, RV; Muller, WJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2808-2813 , 文章类型: Article,,卷期:2012年109-8]
- The tyrosine kinase c-Src is activated in a large proportion of breast cancers, in which it is thought to play a key role in promoting the malignant phenotype. c-Src activity is also elevated in transgenic mouse models o...
- Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
[作者:Owens, P; Pickup, MW; Novitskiy, SV; Chytil, A; Gorska, AE; Aakre, ME; West, J; Moses, HL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2814-2819 , 文章类型: Article,,卷期:2012年109-8]
- Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of signaling molecules. BMPs can elicit a wide range of effects in many cell types and have previously been shown to induce growth inhibition in ...
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