- Multiple Effects of Angiopoietin-2 Blockade on Tumors
[作者:Lewis, CE; Ferrara, N,期刊:Cancer Cell, 页码:431-433 , 文章类型: Editorial Material,,卷期:2011年19-4]
- In this issue of Cancer Cell, Mazzieri, Pucci, and colleagues describe the marked effects of inhibiting the proangiogenic cytokine, Angiopoietin-2, on tumor angiogenesis and progression in spontaneous tumor models, as we...
- Chemokines and Cancer: A Fatal Attraction
[作者:Bonecchi, R; Locati, M; Mantovani, A,期刊:Cancer Cell, 页码:434-435 , 文章类型: Editorial Material,,卷期:2011年19-4]
- Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and cor...
- Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
[作者:Fukuda, A; Wang, SC; Morris, JP; Folias, AE; Liou, A; Kim, GE; Akira, S; Boucher, KM; Firpo, MA; Mulvihill, SJ; Hebrok, M,期刊:Cancer Cell, 页码:441-455 , 文章类型: Article,,卷期:2011年19-4]
- Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the disease. However, the mec...
- Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
[作者:Lesina, M; Kurkowski, MU; Ludes, K; Rose-John, S; Treiber, M; Kloppel, G; Yoshimura, A; Reindl, W; Sipos, B; Akira, S; Schmid, RM; Algul, H,期刊:Cancer Cell, 页码:456-469 , 文章类型: Article,,卷期:2011年19-4]
- Physiological levels of Kras(G12D) are sufficient to induce pancreatic intraepithelial neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we establish that, in addition to oncogenic Kras(...
- Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene
[作者:Stairs, DB; Bayne, LJ; Rhoades, B; Vega, ME; Waldron, TJ; Kalabis, J; Klein-Szanto, A; Lee, JS; Katz, JP; Diehl, JA; Reynolds, AB; Vonderheide, RH; Rustgi, AK,期刊:Cancer Cell, 页码:470-483 , 文章类型: Article,,卷期:2011年19-4]
- p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date. We report herein that p120ctn loss leads to tumor d...
- Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
[作者:Homminga, I; Pieters, R; Langerak, AW; de Rooi, JJ; Stubbs, A; Verstegen, M; Vuerhard, M; Buijs-Gladdines, J; Kooi, C; Klous, P; van Vlierberghe, P; Ferrando, AA; Cayuela, JM; Verhaaf, B; Beverloo, HB; Horstmann, M; de Haas, V; Wiekmeijer, AS; Pike-Overzet, K; Staal, FJT; de Laat, W; Soulier, J; Sigaux, F; Meijerink, JPP,期刊:Cancer Cell, 页码:484-497 , 文章类型: Article,,卷期:2011年19-4]
- To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Confor...
- Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3
[作者:Guryanova, OA; Wu, QL; Cheng, L; Lathia, JD; Huang, Z; Yang, JB; MacSwords, J; Eyler, CE; McLendon, RE; Heddleston, JM; Shou, WN; Hambardzumyan, D; Lee, JW; Hjelmeland, AB; Sloan, AE; Bredel, M; Stark, GR; Rich, JN; Bao, SD,期刊:Cancer Cell, 页码:498-511 , 文章类型: Article,,卷期:2011年19-4]
- Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs a...
- Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
[作者:Mazzieri, R; Pucci, F; Moi, D; Zonari, E; Ranghetti, A; Berti, A; Politi, LS; Gentner, B; Brown, JL; Naldini, L; De Palma, M,期刊:Cancer Cell, 页码:512-526 , 文章类型: Article,,卷期:2011年19-4]
- Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand and angiogenic factor expressed by a...
- A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
[作者:Yi, CL; Troutman, S; Fera, D; Stemmer-Rachamimov, A; Avila, JL; Christian, N; Persson, NL; Shimono, A; Speicher, DW; Marmorstein, R; Holmgren, L; Kissil, JL,期刊:Cancer Cell, 页码:527-540 , 文章类型: Article,,卷期:2011年19-4]
- The Merlin/NF2 tumor suppressor restrains cell growth and tumorigenesis by controlling contact-dependent inhibition of proliferation. We have identified a tight-junction-associated protein complex comprising Merlin, Angi...
- CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
[作者:Chen, JQ; Yao, YD; Gong, C; Yu, FY; Su, SC; Chen, JN; Liu, BD; Deng, H; Wang, FS; Lin, L; Yao, HR; Su, FX; Anderson, KS; Liu, QA; Ewen, ME; Yao, XB; Song, EW,期刊:Cancer Cell, 页码:541-555 , 文章类型: Article,,卷期:2011年19-4]
- Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer strom...
- Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
[作者:Chan, WW; Wise, SC; Kaufman, MD; Ahn, YM; Ensinger, CL; Haack, T; Hood, MM; Jones, J; Lord, JW; Lu, WP; Miller, D; Patt, WC; Smith, BD; Petillo, PA; Rutkoski, TJ; Telikepalli, H; Vogeti, L; Yao, T; Chun, L; Clark, R; Evangelista, P; Gavrilescu, LC; Lazarides, K; Zaleskas, VM; Stewart, LJ; Van Etten, RA; Flynn, DL,期刊:Cancer Cell, 页码:556-568 , 文章类型: Article,,卷期:2011年19-4]
- Acquired resistance to ABL1 tyrosine kinase inhibitors (TKIs) through ABL1 kinase domain mutations, particularly the gatekeeper mutant T315I, is a significant problem for patients with chronic myeloid leukemia (CML). Usi...
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