- GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation
[作者:Chen, Y; Deng, YQ; Zhang, JZ; Yang, L; Xie, XY; Xu, T,期刊:Biochemical Journal, 页码:229-235 , 文章类型: Article,,卷期:2009年422-Part 2]
- Insulin stimulates GLUT4 (glucose transporter 4) translocation in adipocytes and muscles. An emerging picture is that Rab10 could bridge the gap between the insulin signalling cascade and GLUT4 translocation in adipocyte...
- Differential contributions of Glu(96), Asp(102) and Asp(111) to coagulation Factor V/Va metal ion binding and subunit stability
[作者:Song, J; Talbot, K; Hewittt, J; MacGillivray, RTA; Pryzdial, ELG,期刊:Biochemical Journal, 页码:257-264 , 文章类型: Article,,卷期:2009年422-Part 2]
- Blood coagulation FV (Factor V) is activated by thrombin-mediated excision of the B domain, resulting in a non-covalent heterodimer, FVa (activated FV). Previous studies implicated Glu(96), Asp(102) and Asp(111) in the e...
- Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism
[作者:Donini, S; Ferrari, M; Fedeli, C; Faini, M; Lamberto, I; Marletta, AS; Mellini, L; Panini, M; Percudani, R; Pollegioni, L; Caldinelli, L; Petrucco, S; Peracchi, A,期刊:Biochemical Journal, 页码:265-272 , 文章类型: Article,,卷期:2009年422-Part 2]
- PH1 (primary hyperoxaluria type 1) is a severe inborn disorder of glyoxylate metabolism caused by a functional deficiency of the peroxisomal enzyme AGXT (alanine-glyoxylate aminotransferase), which converts glyoxylate in...
- Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity
[作者:Lin, HL; Burton, D; Li, LT; Warner, DE; Phillips, JD; Ward, DM; Kaplan, J,期刊:Biochemical Journal, 页码:273-283 , 文章类型: Article,,卷期:2009年422-Part 2]
- Cation diffusion facilitator transporters are found in all three Kingdoms of life and are involved in transporting transition metals out of the cytosol. The metals they transport include Zn2+, Co2+, Fe2+, Cd2+, Ni2+ and ...
- Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity
[作者:Gentile, F; Pizzimenti, S; Arcaro, A; Pettazzoni, P; Minelli, R; D'Angelo, D; Mamone, G; Ferranti, P; Toaldo, C; Cetrangolo, G; Formisano, S; Dianzani, MU; Uchida, K; Dianzani, C; Barrera, G,期刊:Biochemical Journal, 页码:285-294 , 文章类型: Article,,卷期:2009年422-Part 2]
- HNE (4-hydroxynonenal), the major product of lipoperoxidation, easily reacts with proteins through adduct formation between its three main functional groups and lysyl, histidyl and cysteinyl residues of proteins. HNE is ...
- Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1
[作者:Murray-Rust, TA; Kerr, FK; Thomas, AR; Wu, TN; Yongqing, T; Ong, PC; Quinsey, NS; Whisstock, JC; Wagenaar-Bos, IC; Freeman, C; Pike, RN,期刊:Biochemical Journal, 页码:295-303 , 文章类型: Article,,卷期:2009年422-Part 2]
- The complement system plays crucial roles in the immune system, but incorrect regulation causes inflammation and targeting of self-tissue, leading to diseases such as systemic lupus erythematosus, rheumatoid arthritis an...
- Coupling oxidative signals to protein phosphorylation via methionine oxidation in Arabidopsis
[作者:Hardin, SC; Larue, CT; Oh, MH; Jain, V; Huber, SC,期刊:Biochemical Journal, 页码:305-312 , 文章类型: Article,,卷期:2009年422-Part 2]
- The mechanisms involved in sensing oxidative signalling molecules, such as H2O2, in plant and animal cells are not completely understood. In the present study, we tested the postulate that oxidation of Met (methionine) t...
- Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes
[作者:Iuchi, Y; Okada, F; Takamiya, R; Kibe, N; Tsunoda, S; Nakajima, O; Toyoda, K; Nagae, R; Suematsu, M; Soga, T; Uchida, K; Fujii, J,期刊:Biochemical Journal, 页码:313-320 , 文章类型: Article,,卷期:2009年422-Part 2]
- Oxidative stress has been implicated as a cause of various diseases such as anaemia. We found that the SOD1 [Cu,Zn-SOD (superoxide dismutase)] gene deficiency causes anaemia, the production of autoantibodies against RBCs...
- Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues
[作者:Hyvonen, MT; Howard, MT; Anderson, CB; Grigorenko, N; Khomutov, AR; Vepsalainen, J; Alhonen, L; Janne, J; Keinanen, TA,期刊:Biochemical Journal, 页码:321-328 , 文章类型: Article,,卷期:2009年422-Part 2]
- The natural polyamines are ubiquitous multifunctional organic cations which play important roles in regulating cellular proliferation and survival. Here we present a novel approach to investigating polyamine functions by...
- The 5 ' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2
[作者:Felice, KM; Salzman, DW; Shubert-Coleman, J; Jensen, KP; Furneaux, HM,期刊:Biochemical Journal, 页码:329-341 , 文章类型: Article,,卷期:2009年422-Part 2]
- Small RNAs modulate gene expression by forming a ribonucleoprotein complex with Argonaute proteins and directing them to specific complementary sites in target nucleic acids. However, the interactions required for the re...
- P/CAF rescues the Bhlhe40-mediated repression of MyoD transactivation
[作者:Hsiao, SP; Huang, KM; Chang, HY; Chen, SL,期刊:Biochemical Journal, 页码:343-352 , 文章类型: Article,,卷期:2009年422-Part 2]
- Previously, we found that MRFs (myogenic regulatory factors) regulated the expression of PGC-1 alpha (peroxisome-proliferator-activated receptor gamma co-activator 1 alpha) by targeting a short region, from nt -49 to +2 ...
- Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions
[作者:Wright, MM; Kim, J; Hock, TD; Leitinger, N; Freeman, BA; Agarwal, A,期刊:Biochemical Journal, 页码:353-361 , 文章类型: Article,,卷期:2009年422-Part 2]
- Nitro-fatty acid products of oxidative inflammatory reactions mediate anti-inflammatory cell signalling responses. LNO2 (nitro-linoleic acid) induces expression of HO-1 (haem oxygenase-1), an enzyme that catabolizes haem...
- A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway
[作者:Li, CS; Chen, HY; Ding, F; Zhang, Y; Luo, AP; Wang, MR; Liu, ZH,期刊:Biochemical Journal, 页码:363-372 , 文章类型: Article,,卷期:2009年422-Part 2]
- S100A9 (S100 calcium-binding protein A9) is a calcium-binding protein of the S100 family, and its differential expression has been associated with acute and chronic inflammation and several human cancers. Our previous wo...
- The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases
[作者:Miyano, K; Koga, H; Minakami, R; Sumimoto, H,期刊:Biochemical Journal, 页码:373-382 , 文章类型: Article,,卷期:2009年422-Part 2]
- Rac1 and Rac2, which belong to the Rho subfamily of Ras-related GTPascs, play an essential role in activation of gp91(phox)/Nox2 (cytochrome b-245, beta polypeptide; also known as Cybb), the catalytic core of the superox...
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