- Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal
[作者:Hill, BG; Dranka, BP; Zou, LY; Chatham, JC; Darley-Usmar, VM,期刊:Biochemical Journal, 页码:99-107 , 文章类型: Article,,卷期:2009年424-Part 1]
- Mitochondria play a critical role in mediating the Cellular response to oxidants formed during acute and chronic cardiac dysfunction. It is widely assumed that, as cells are subjected to stress, mitochondria are capable ...
- IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2
[作者:Handoyo, H; Stafford, MJ; McManus, E; Baltzis, D; Peggie, M; Cohen, P,期刊:Biochemical Journal, 页码:109-118 , 文章类型: Article,,卷期:2009年424-Part 1]
- The protein kinase Tpl2 (tumour progression locus 2) is activated by LPS (lipopolysaccharide), TNF alpha (tumour necrosis factor alpha) and IL (interleukin)-1. Activation of the native Tpl2 complex by these agonists requ...
- The human urocortin 2 gene is regulated by hypoxia: identification of a hypoxia-responsive element in the 3 '-flanking region
[作者:Buhler, K; Plaisance, I; Dieterle, T; Brink, M,期刊:Biochemical Journal, 页码:119-127 , 文章类型: Article,,卷期:2009年424-Part 1]
- Ucn2 (urocortin 2) has been shown to exert potent beneficial effects in the cardiovascular system, including inhibition of apoptosis, improvement of cardiomyocyte contractility and decrease of oxidative stress. The mecha...
- Escherichia coli glycogen metabolism is controlled by the PhoP-PhoQ regulatory system at submillimolar environmental Mg2+ concentrations, and is highly interconnected with a wide variety of cellular processes
[作者:Montero, M; Eydallin, G; Viale, AM; Almagro, G; Munoz, FJ; Rahimpour, M; Sesma, MT; Baroja-Fernandez, E; Pozueta-Romero, J,期刊:Biochemical Journal, 页码:129-141 , 文章类型: Article,,卷期:2009年424-Part 1]
- Using the Keio collection of gene-disrupted mutants of Escherichia coli, we have recently carried Out a genome-wide screening of the genes affecting glycogen metabolism. Among the mutants identified in the study, Delta m...
- The human HIF (hypoxia-inducible factor)-3 alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction
[作者:Tanaka, T; Wiesener, M; Bernhardt, W; Eckardt, KU; Warnecke, C,期刊:Biochemical Journal, 页码:143-151 , 文章类型: Article,,卷期:2009年424-Part 1]
- HIF (hypoxia-inducible factor)-3 alpha is the third member of the HIF transcription factor family. Whereas HIF-1 alpha and -2 alpha play critical roles in the cellular and systemic adaptation to hypoxia, little is known ...
- Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation
[作者:Madigan, JP; Bodemann, BO; Brady, DC; Dewar, BJ; Keller, PJ; Leitges, M; Philips, MR; Ridley, AJ; Der, CJ; Cox, AD,期刊:Biochemical Journal, 页码:153-161 , 文章类型: Article,,卷期:2009年424-Part 1]
- The Rnd proteins (Rnd1, Rnd2 and Rnd3/RhoE) form a distinct branch of the Rho family of small GTPases. Altered Rnd3 expression causes changes in cytoskeletal organization and cell cycle progression. Rnd3 functions to dec...
- EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1
[作者:Bisson, MMA; Bleckmann, A; Allekotte, S; Groth, G,期刊:Biochemical Journal, 页码:1-6 , 文章类型: Article,,卷期:2009年424-Part 1]
- Genetic studies have identified the membrane protein EIN2 (ethylene insensitive 2) as a central component of ethylene signalling in Arabidopsis. In addition, EIN2 might take part in multiple hormone signalling pathways a...
- Existence of exocytotic hemifusion intermediates with a lifetime of up to seconds in type II pneumocytes
[作者:Miklavc, P; Albrecht, S; Wittekindt, OH; Schullian, P; Haller, T; Dietl, P,期刊:Biochemical Journal, 页码:7-14 , 文章类型: Article,,卷期:2009年424-Part 1]
- Exocytosis proceeds through prefusion stages such as hemifusion, but hemifusion is still an elusive intermediate of unknown duration. Using darkfield and fluorescence microscopy in ATII (alveolar type II) cells containin...
- A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity
[作者:Allali-Hassani, A; Wasney, GA; Chau, I; Hong, BS; Senisterra, G; Loppnau, P; Shi, Z; Moult, J; Edwards, AM; Arrowsmith, CH; Park, HW; Schapira, M; Vedadi, M,期刊:Biochemical Journal, 页码:15-26 , 文章类型: Article,,卷期:2009年424-Part 1]
- On average, each human gene has approximately four SNPs (single nucleotide polymorphisms) in the coding region, half of which are nsSNPs (non-synonymous SNPs) or missense SNPs. Current attention is focused on those that ...
- Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage
[作者:Poon, IKH; Olsson, AK; Hulett, MD; Parish, CR,期刊:Biochemical Journal, 页码:27-37 , 文章类型: Article,,卷期:2009年424-Part 1]
- The plasminogen/plasmin system is involved in a variety of normal physiological and pathological processes, including tissue remodelling, angiogenesis and tumour metastasis. Plasminogen activators and receptors for plasm...
- Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands
[作者:Hu, LYA; Zhou, T; Ahn, J; Wang, SL; Zhou, J; Hu, Y; Liu, QY,期刊:Biochemical Journal, 页码:39-45 , 文章类型: Article,,卷期:2009年424-Part 1]
- TAARs (trace amine-associated receptors) are G-protein-coupled receptors that respond to low abundance, endogenous amines such as tyramine and tryptamine, and represent potential targets for neuropsychiatric diseases. Ho...
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
[作者:Nichols, RJ; Dzamko, N; Hutti, JE; Cantley, LC; Deak, M; Moran, J; Bamborough, P; Reith, AD; Alessi, DR,期刊:Biochemical Journal, 页码:47-60 , 文章类型: Article,,卷期:2009年424-Part 1]
- The LRRK2 (leucine-rich repeat protein kinase-2) is mutated in a significant number of Parkinson's disease patients, but little is known about its regulation and function. A common mutation changing Gly(2019) to serine e...
- Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae
[作者:Fei, WH; Wang, H; Fu, X; Bielby, C; Yang, HY,期刊:Biochemical Journal, 页码:61-67 , 文章类型: Article,,卷期:2009年424-Part 1]
- LDs (lipid droplets) are cellular organelles which can be found in nearly all eukaryotic cells. Despite their importance in cell biology, the mechanism underlying LD biogenesis remains largely unknown. In the present stu...
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