- Identification of virus resistant tumor cell subpopulations in three-dimensional uveal melanoma cultures
[作者:Valyi-Nagy, K; Dosa, S; Kovacs, SK; Bacsa, S; Voros, A; Shukla, D; Folberg, R; Valyi-Nagy, T,期刊:Cancer gene therapy, 页码:223-234 , 文章类型: Article,,卷期:2010年17-4]
- To better understand melanoma resistance to herpes simplex virus type 1 (HSV-1)-mediated oncolysis, traditional two-dimensional (2D) cultures and extracellular matrix (ECM) containing three-dimensional (3D) cultures of O...
- A modified hTERT promoter-directed oncolytic adenovirus replication with concurrent inhibition of TGF beta signaling for breast cancer therapy
[作者:Hu, Z; Robbins, JS; Pister, A; Zafar, MB; Zhang, ZW; Gupta, J; Lee, KJ; Neuman, K; Yun, CO; Guise, T; Seth, P,期刊:Cancer gene therapy, 页码:235-243 , 文章类型: Article,,卷期:2010年17-4]
- We were interested in developing oncolytic adenoviral vectors that can be administered systemically for the treatment of breast cancer. To restrict viral replication in breast tumor cells, we constructed mhTERTAd.sTbRFc,...
- Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor
[作者:Tseng, JC; Granot, T; DiGiacomo, V; Levin, B; Meruelo, D,期刊:Cancer gene therapy, 页码:244-255 , 文章类型: Article,,卷期:2010年17-4]
- Genetic instability of cancer cells generates resistance after initial responses to chemotherapeutic agents. Several oncolytic viruses have been designed to exploit specific signatures of cancer cells, such as important ...
- Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer
[作者:Lin, EH; Salon, C; Brambilla, E; Lavillette, D; Szecsi, J; Cosset, FL; Coll, JL,期刊:Cancer gene therapy, 页码:256-265 , 文章类型: Article,,卷期:2010年17-4]
- Fusogenic membrane glycoproteins (FMGs) are viral envelope proteins, which bind surface receptors and induce fusion of the cell membrane. An FMG-transfected cell will fuse with neighbor cells, thus forming syncytia that ...
- Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter
[作者:Prabhakar, S; Brenner, GJ; Sung, B; Messerli, SM; Mao, J; Sena-Esteves, M; Stemmer-Rachamimov, A; Tannous, B; Breakefield, XO,期刊:Cancer gene therapy, 页码:266-274 , 文章类型: Article,,卷期:2010年17-4]
- Schwannomas are benign tumors forming along peripheral nerves that can cause deafness, pain and paralysis. Current treatment involves surgical resection, which can damage associated nerves. To achieve tumor regression wi...
- Survivin knockdown by short hairpin RNA abrogates the growth of human hepatocellular carcinoma xenografts in nude mice
[作者:Zhang, R; Ma, L; Zheng, M; Ren, J; Wang, T; Meng, Y; Zhao, J; Jia, L; Yao, L; Han, H; Li, K; Yang, A,期刊:Cancer gene therapy, 页码:275-288 , 文章类型: Article,,卷期:2010年17-4]
- Abnormal high activation of survivin is involved in carcinogenesis of various types of cancer. Survivin has been shown to promote cell proliferation in human hepatocellular carcinoma (HCC). Survivin-targeting approaches ...
- Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells
[作者:Dembinski, JL; Spaeth, EL; Fueyo, J; Gomez-Manzano, C; Studeny, M; Andreeff, M; Marini, FC,期刊:Cancer gene therapy, 页码:289-297 , 文章类型: Article,,卷期:2010年17-4]
- The fiber-modified adenoviral vector D-24-RGD (D24RGD) offers vast therapeutic potential. Direct injection of D24RGD has been used to successfully target ovarian tumors in mice. However, systemic toxicity, especially in ...
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