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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Role of organic cation transporters in dopamine uptake across olfactory and nasal respiratory tissues [作者：Chemuturi, NV; Donovan, MD,期刊：Molecular Pharmaceutics, 页码：936-942 , 文章类型： Article，,卷期：2007年4-6] Dopamine has poor oral bioavailability and low permeability across the blood-brain barrier, and yet it has been reported to have good systemic and central nervous system (CNS) bioavailability following nasal administrati... Anomalous release of hydrophilic drugs from poly(epsilon-caprolactone) matrices [作者：Rosenberg, R; Devenney, W; Siegel, S; Dan, N,期刊：Molecular Pharmaceutics, 页码：943-948 , 文章类型： Article，,卷期：2007年4-6] In this paper, we investigate the release of two drugs, nicotine and caffeine, from poly c-caprolactone (PCL) matrices, as a model for the delivery of highly hydrophilic drugs. Since PCL does not degrade over the period ... Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: Effects of quercetin and EGCG on biochanin a disposition in rats [作者：Moon, YJ; Morris, ME,期刊：Molecular Pharmaceutics, 页码：865-872 , 文章类型： Article，,卷期：2007年4-6] Little is known regarding pharmacokinetic (PK) or pharmacodynamic interactions of flavonoids with each other: this is of significance since multiple flavonoids are present in the diet and in dietary supplements. Our obje... Disposition of flavonoids via enteric recycling: Determination of the UDP-Glucuronosyltransferase Isoforms responsible for the metabolism of flavonoids in intact caco-2 TC7 cells using siRNA [作者：Liu, X; Tam, VH; Hu, M,期刊：Molecular Pharmaceutics, 页码：873-882 , 文章类型： Article，,卷期：2007年4-6] Our recent study indicates that microsomal glucuronidation rates are not predictive of the cellular glucuronide excretion rates and whole cell systems are needed to accurately determine the metabolic rates. This study ai... Disposition of flavonoids via enteric recycling: Enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms [作者：Joseph, TB; Wang, SWJ; Liu, X; Kulkarni, KH; Wang, JR; Xu, H; Hu, M,期刊：Molecular Pharmaceutics, 页码：883-894 , 文章类型： Article，,卷期：2007年4-6] We characterized the in vitro glucuronidation of prunetin, a prodrug of genistein that is a highly active cancer prevention agent. Metabolism studies were conducted using expressed human UGT isoforms and microsomes/S9 fr... Thermodynamic study of sublimation, solubility, solvation, and distribution processes of atenolol and pindolol [作者：Perlovich, GL; Volkova, TV; Bauer-Brandl, A,期刊：Molecular Pharmaceutics, 页码：929-935 , 文章类型： Article，,卷期：2007年4-6] Temperature dependency of saturated vapor pressure, thermochemical, and thermodynamic characteristics of sublimation, as well as fusion and vaporization processes, for atenolol and pindolol was studied. Specific and nons... Impact of surface derivatization of poly-L-lysine dendrimers with anionic aryisulfonate or succinate groups on intravenous pharmacokinetics and disposition [作者：Kaminskas, LM; Boyd, BJ; Karellas, P; Henderson, SA; Giannis, MP; Krippner, GY; Porter, CJH,期刊：Molecular Pharmaceutics, 页码：949-961 , 文章类型： Article，,卷期：2007年4-6] Tritrium-labeled poly-L-lysine dendrimers displaying 8 or 16 surface lysines have been capped with benzene sulfonate (BS), benzene disulfonate (BDS), or succinate (Succ) groups, and the intravenous pharmacokinetics and d... Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis [作者：Doshi, JM; Tian, DF; Xing, CG,期刊：Molecular Pharmaceutics, 页码：919-928 , 文章类型： Article，,卷期：2007年4-6] Overexpressing antiapoptotic Bcl-2 proteins to suppress apoptosis is one major mechanism via which cancer cells acquire drug resistance against cancer therapy. Ethyl-2amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chro... Single lipoplex study of cationic Lipoid-DNA, self-assembled complexes [作者：Pozharski, EV; MacDonald, RC,期刊：Molecular Pharmaceutics, 页码：962-974 , 文章类型： Article，,卷期：2007年4-6] A flow fluorometric analysis (using a commercial flow cytometer) of individual cationic lipoid-DNA complexes is presented. Such single lipoplex studies have the advantage of providing detailed characterization of heterog... Bioavailability of curcumin: Problems and promises [作者：Anand, P; Kunnumakkara, AB; Newman, RA; Aggarwal, BB,期刊：Molecular Pharmaceutics, 页码：807-818 , 文章类型： Review，,卷期：2007年4-6] Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Phase I clinical t... Biotransformation of green tea polyphenols and the biological activities of those metabolites [作者：Lambert, JD; Sang, SM; Yang, CS,期刊：Molecular Pharmaceutics, 页码：819-825 , 文章类型： Review，,卷期：2007年4-6] Green tea (Camellia sinensis, Theaceae) and its major polyphenol constituents, the catechins, have been reported to have many health benefits including the prevention of cancer and heart disease. Many mechanisms of actio... Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption [作者：Walle, T,期刊：Molecular Pharmaceutics, 页码：826-832 , 文章类型： Review，,卷期：2007年4-6] Dietary flavonoids and other polyphenols have many biological properties that could make them useful as chemopreventive agents. However, very poor oral bioavailability makes them largely ineffective in vivo. The low bioa... Intestinal and hepatic glucuronidation of flavonoids [作者：Zhang, L; Zuo, Z; Lin, G,期刊：Molecular Pharmaceutics, 页码：833-845 , 文章类型： Review，,卷期：2007年4-6] Flavonoids are polyphenolic phytochemicals present extensively in our daily diets, beverages, medicinal plants, and herbal remedies. The diverse biological effects of flavonoids have aroused great interest in scientists.... Metabolism and bioavailability of flavonoids in chemoprevention: Current analytical strategies and future prospectus [作者：Prasain, JK; Barnes, S,期刊：Molecular Pharmaceutics, 页码：846-864 , 文章类型： Review，,卷期：2007年4-6] Flavonoids are structurally diverse and among the most ubiquitous groups of dietary polyphenols distributed in various fruits and vegetables. Many have been proposed to be bioactive compounds in the diet that are respons... Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors [作者：Marschall, HU; Wagner, M; Zollner, G; Trauner, M,期刊：Molecular Pharmaceutics, 页码：895-910 , 文章类型： Review，,卷期：2007年4-6] Drug-induced liver injury (DILI) is a rare condition. This review presents a clinical update on the incidence and prevalence of DILI, cellular targets and histopathological features of liver injury, and basic diagnostic ... Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity [作者：Marion, TL; Leslie, EM; Brouwer, KLR,期刊：Molecular Pharmaceutics, 页码：911-918 , 文章类型： Review，,卷期：2007年4-6] Drug-induced liver toxicity is a significant problem in drug development and clinical practice, yet its mechanisms are not well understood. Growing evidence suggests that inhibition of bile acid transport may be one mech...